Observation on the Effect of Bone Grafting Alone and Guided Tissue Regeneration Combined with Bone Grafting to Repair Periodontal Intraosseous Defects

Yuan, Yongping; Zhao, Jiajia; He, Nv

doi:10.1155/2021/1743677

Cited by 6 publications

(7 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This limits their widespread use as a primary treatment for periodontitis. Several studies have demonstrated the effectiveness of bone grafting in improving clinical outcomes in periodontal regeneration, although more long-term randomized controlled trials are needed to establish their efficacy and safety [ 39 – 42 ].…”

Section: Discussionmentioning

confidence: 99%

Brief literature review and comprehensive bioinformatics analytics unravel the potential mechanism of curcumin in the treatment of periodontitis

et al. 2023

View full text Add to dashboard Cite

Objective Periodontitis is a chronic oral disease prevalent worldwide, and natural products are recommended as adjunctive therapy due to their minor side effects. Curcumin, a widely used ancient compound, has been reported to possess therapeutic effects in periodontitis. However, the exact mechanism underlying its activity remains unclear. In this context, the present study aimed to conduct computational simulations to uncover the potential mechanism of action of Curcumin in the treatment of periodontitis. Materials and methods Single-cell analysis was conducted using a dataset (i.e., GSE164241) curated from the Gene Expression Omnibus (GEO) database through an R package "Seurat package." Bulk RNA sequencing data were curated from GSE10334 and GSE16134 and processed by R package "Limma." Then, the marker genes in the single-cell transcriptome and differentially expressed genes (DEGs) in the bulk transcriptome were integrated. Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) analyses were also carried out to reveal their functionalities. Key targets were mined from their protein–protein interaction (PPI) network topologically. Afterward, molecular docking was performed. The top-ranked pose was subjected to molecular dynamics simulations to investigate the stability of the docking result. Results FOS, CXCL1, CXCL8, and IL1B, were filtered after a series of selected processes. The results of molecular modeling suggested that except for IL1B, the Vena Scores of the rest exceeded -5 kcal/mol. Furthermore, the molecular dynamic simulation indicated that the binding of the CXCL8-Curcumin complex was stable over the entire 100 ns simulation. Conclusion The present study unlocked the binding modes of CXCL1, FOS, and CXCL8 with the Curcumin molecule, which were relatively stable, especially for CXCL8, hindering its promising potential to serve as the critical targets of Curcumin in periodontitis treatment.

show abstract

Section: Discussionmentioning

confidence: 99%

Brief literature review and comprehensive bioinformatics analytics unravel the potential mechanism of curcumin in the treatment of periodontitis

et al. 2023

View full text Add to dashboard Cite

show abstract

“…PRF enhances wound healing and regeneration and several studies have shown rapid and accelerated woundhealing with the use of PRF than without it 5 . It showed that the GTR combined with bone grafting was better than bone grafting alone in improving the aesthetics of the patients' gums, which might be related to its promotion of soft tissue healing and good integration of soft tissues 6 .…”

Section: Introductionmentioning

confidence: 99%

Surgical treatment of periodontal pocket with guided bone and soft tissue regeneration

Evrosimovska¹,

Janeva²,

Janeva³

2021

MSP

View full text Add to dashboard Cite

Periodontal disease is defined as a complex, multifactorial disease characterized by the loss of connective tissue attachment with destruction of periodontal tissues. The aim of periodontal therapy is to eliminate the inflammatory process, prevent the progression of periodontal disease and also to regenerate the lost periodontal tissues. Loss of bone support by creating a periodontal pocket is one of the most common causes of tooth extraction. Their treatment can be conservative and surgical. The purpose of this paper is to demonstrate the treatment of infrabony periodontal defects with bone and soft tissue regeneration. On periodontal examination and radiographic evaluation, a female 56-year-old patient presented with an infrabony defect extending up to the apical third of the mesial side of the right maxillary second molar with a probing depth of 8 mm. After conservative periodontal treatment, oral surgical intervention was performed including open flap debridement and filling the defect with xenograft and plasma rich fibrin. The application of xenograft and Plasma rich fibrin resulted in bone regeneration of the defect and successful fixed prosthodontic solution. Guided bone and soft tissue regeneration using xenograft and fibrin-rich plasma gives successful radiological and clinical signs of bone augmentation and consolidation of defects caused by loss of tooth attachment.

show abstract

“…It has been reported that guided tissue regeneration with bone replacement or transplantation may improve clinical outcomes of periodontal intraosseous defects [ 12 , 13 ]. The physiological traits of bone grafts and bone substitute materials (BSM) are typically described using osteoinduction, osteoconduction, and osteogenesis [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Clinical and Radiographic Evaluation of Autologous Platelet-Rich Fibrin With or Without Demineralized Bone Matrix in the Treatment of Grade II Furcation Defects

Patel,

Joshi,

Nagrani

et al. 2023

Cureus

View full text Add to dashboard Cite

Introduction This study aims to differentiate the employment of demineralized bone matrix (DMBM; Osseograft, Advanced Biotech Products (P) Ltd, Chennai, India) and platelet-rich fibrin (PRF) alone to a composite graft consisting of both materials in the surgical actions toward the anomalies of the human periodontal furcation imperfection. Methods In a split-mouth study, 30 patients with mandibular molars affected by the furcation were allocated without conscious choice to test (PRF + DMBM, n = 30) or control (PRF, n = 30) categories. At the starting point, three months after surgery, and six months later, the following modifiable factors were evaluated: probing pocket depth (PPD), full-mouth plaque scores, full-mouth gingival scores, radiographic defect depth, relative vertical clinical attachment level (RVCAL), and relative horizontal clinical attachment level (RHCAL). Results Results at three and six months demonstrated substantial differences between baseline values for both treatment methods in clinical and X-ray imaging appraisal. Nonetheless, the PRF/DMBM group manifests statistically significantly soaring changes observed in comparison to the PRF group. Overall, the probing depth (PD) in the test site was significantly lower than that in the control site, showing a reduction of 68% (95% CI=41%, 95%, p<0.001). Conclusion Clinical indications significantly improved with PRF and DMBM combined instead of PRF alone. On radiographs, the test group also showed higher bone fill.

show abstract

Observation on the Effect of Bone Grafting Alone and Guided Tissue Regeneration Combined with Bone Grafting to Repair Periodontal Intraosseous Defects

Cited by 6 publications

References 25 publications

Brief literature review and comprehensive bioinformatics analytics unravel the potential mechanism of curcumin in the treatment of periodontitis

Brief literature review and comprehensive bioinformatics analytics unravel the potential mechanism of curcumin in the treatment of periodontitis

Surgical treatment of periodontal pocket with guided bone and soft tissue regeneration

Clinical and Radiographic Evaluation of Autologous Platelet-Rich Fibrin With or Without Demineralized Bone Matrix in the Treatment of Grade II Furcation Defects

Contact Info

Product

Resources

About