Observations in the developing human eye regarding Lange’s fold

Herwig, Martina C.; Münstermann, Kathrin; Müller, Annette; Loeffler, Karin U.

doi:10.1111/aos.12191

Cited by 3 publications

(1 citation statement)

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“…Durch die Fixierung kommt es zu einer Schrumpfung des Gewebes, die lockere Gewebestrukturen wie die Chorioidea mehr betrifft als hochzelluläre (wie die Retina) oder kompakte Gewebe [26]. Zu den postmortalen Fixationsartefakten gehören insbesondere die Lange-Falte (eine retinale Falte am Übergang zur Ora serrata), die Netzhautablösung (durch Verlust der Pumpfunktion des RPE sowie unterschiedliche Schrumpfungstendenz der fixierten Gewebe) sowie retinale Falten [27][28][29]. Im Falle der Linse führt eine Fixierung des Bulbus in Karnovsky-Lösung zu einer makroskopischen Gelbfärbung der Linse, die nicht mit einer Katarakt verwechselt werden sollte.…”

Section: Fixationsbedingte Artefakteunclassified

Routineuntersuchung fetaler Augen – wie und warum?

Herwig

Löffler

2014

Klin Monatsbl Augenheilkd

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The investigation of foetal eyes not only allows for the observation of ocular development. It is supportive and sometimes even mandatory for the diagnosis of systemic and ocular syndromes. This review gives an overview about the investigation of foetal eyes, their assignment to developmental stages, challenges related to the investigation of foetal eyes, clinically relevant syndromes, and academic questions. The morphological development of the eye has been investigated since the 19th century and will not be covered in this article. The investigation of foetal eyes that have been collected during the routine paediatric autopsy, is complicated by artifacts. Artifacts are the result of autolysis, fixation, and mechanical manipulation. They have to be distinguished from genuine findings. Besides the search for findings such as coloboma or cataract, the morphological classification of the foetal eye is of importance. The anterior-posterior diameter allows for the diagnosis of microphthalmia. The case reports comprise Goldenhar's syndrome, MIDAS syndrome and others. In conclusion, the investigation of foetal eyes is often helpful and critical for paediatric diagnostics and should be performed with great care.

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Section: Fixationsbedingte Artefakteunclassified

Routineuntersuchung fetaler Augen – wie und warum?

Herwig

Löffler

2014

Klin Monatsbl Augenheilkd

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Artifacts

Verdijk¹,

Herwig‐Carl²

2020

Fetal and Neonatal Eye Pathology

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Bedeutung der Untersuchung fetaler Augen

2017

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The investigation of fetal eyes is a subspecialty, which is performed by only a few ophthalmic pathologists and pathologists in specialized centers. If a certain fetal syndrome is suspected, the fetal eyes should be removed and submitted for ophthalmic pathological investigation in a specialized center. This can provide additional diagnostic information allowing a final classification of a syndrome and the comprehensive genetic counselling of parents with respect to future pregnancies. This article provides an overview of the histopathological findings in fetal eyes, which are of particular relevance for the pediatric pathological autopsy. In addition, the basic points of ocular development, the preparation of fetal eyes and frequent artifacts are presented.

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Observations in the developing human eye regarding Lange’s fold

Cited by 3 publications

References 3 publications

Routineuntersuchung fetaler Augen – wie und warum?

Routineuntersuchung fetaler Augen – wie und warum?

Artifacts

Bedeutung der Untersuchung fetaler Augen

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