Observations on Acne, Seborrhoea, and Obesity

Bourne, S; Jacobs, A.

doi:10.1136/bmj.1.4978.1268

Cited by 41 publications

(24 citation statements)

References 6 publications

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“…A major study evaluated 2,720 military recruited for obesity and acne and found this association in only two individuals, aged between 20 and 40 years. No association was found among adolescents aged [15][16][17][18][19] years. This suggests that acne, in a younger population, may be associated with other factors besides obesity and insulin resistance.…”

Section: Hypothesis N 0 1: Obesity and Acne: It Is Not How Much You Ementioning

confidence: 85%

“…This suggests that acne, in a younger population, may be associated with other factors besides obesity and insulin resistance. 15 In a recent study with twins -458 monozygotic and 1,099 dizygotic -there was no significant difference in the clinical profile of acne among the twins in relation to weight, body mass index, cholesterol, triglycerides and glucose levels in the blood. 16 The results of the two studies mentioned above show that it is not how much we eat that affects the development and severity of acne, but what we eat may play a role.…”

Section: Hypothesis N 0 1: Obesity and Acne: It Is Not How Much You Ementioning

confidence: 93%

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Acne e dieta: verdade ou mito?

Costa

Lage

Moisés

2010

An. Bras. Dermatol.

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Numerous studies were published over the last 50 years to investigate whether diet is associated with the etiology of acne. Although older studies well known by dermatologists that refute the association between acne and diet exist, their scientific foundation is weak. New articles have recently brought to light evidence contrary to previous findings. Therefore, we would like to investigate whether diet, directly or indirectly, influences one or more of the four fundamental etiopathogenic pillars of acne: (1) hyperproliferation of basal keratinocytes, (2) increase of sebaceous production, (3) colonization by Propionibacterium acnes, and (4) inflammation. Keywords: Acne vulgaris; Diet; Glycemic index Resumo: Nos últimos 50 anos, foram publicados inúmeros estudos com a finalidade de comprovar se a dieta está relacionada à etiologia da acne. Embora existam estudos antigos, que são bem difundidos entre os dermatologistas e negam a associação entre acne e dieta, seu delineamento científico é pobre. Recentemente, novos artigos demonstraram evidências contrárias às publicações anteriores. Sendo assim, os autores realizaram esta revisão bibliográfica com o intuito de averiguar se a dieta influencia direta ou indiretamente um ou mais dos quatro pilares etiopatogênicos fundamentais da acne: (1) hiperproliferação dos queratinócitos basais, (2) aumento da produção sebácea, (3) colonização pelo Propionibacterium acnes e (4) inflamação.

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Section: Hypothesis N 0 1: Obesity and Acne: It Is Not How Much You Ementioning

confidence: 85%

Section: Hypothesis N 0 1: Obesity and Acne: It Is Not How Much You Ementioning

confidence: 93%

Acne e dieta: verdade ou mito?

Costa

Lage

Moisés

2010

An. Bras. Dermatol.

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“…Aizawa and Niimura (36) showed mild peripheral insulin resistance in female acne sufferers that was not associated with obesity or menstrual irregularities. In contrast, Bourne and Jacobs (29) showed that adult men with acne were significantly heavier (5.6 kg) than men without acne. However, the authors showed that this association was dependent on age, because weight was not associated with acne in adolescents aged 15-19 y.…”

Section: Discussionmentioning

confidence: 97%

“…Insulin resistance is believed to be the underlying disturbance in PCOS, because it generally precedes and gives rise to the cluster of endocrine abnormalities that characterize PCOS (elevated androgen and IGF-I concentrations and low sex hormone-binding globulin; 28). Treatments for PCOS now include oral hypoglycemic agents, which improve insulin sensitivity, restore fertility, and alleviate acne (29).…”

Section: Discussionmentioning

confidence: 99%

A low-glycemic-load diet improves symptoms in acne vulgaris patients: a randomized controlled trial

Smith

Mann

Braue

et al. 2007

The American Journal of Clinical Nutrition

242

178

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Background: Although the pathogenesis of acne is currently unknown, recent epidemiologic studies of non-Westernized populations suggest that dietary factors, including the glycemic load, may be involved. Objective: The objective was to determine whether a low-glycemicload diet improves acne lesion counts in young males. Design: Forty-three male acne patients aged 15-25 y were recruited for a 12-wk, parallel design, dietary intervention incorporating investigator-blinded dermatology assessments. The experimental treatment was a low-glycemic-load diet composed of 25% energy from protein and 45% from low-glycemic-index carbohydrates. In contrast, the control situation emphasized carbohydrate-dense foods without reference to the glycemic index. Acne lesion counts and severity were assessed during monthly visits, and insulin sensitivity (using the homeostasis model assessment) was measured at baseline and 12 wk. Results: At 12 wk, mean (ȀSEM) total lesion counts had decreased more (P ҃ 0.03) in the low-glycemic-load group (Ҁ23.5 Ȁ 3.9) than in the control group (Ҁ12.0 Ȁ 3.5). The experimental diet also resulted in a greater reduction in weight (Ҁ2.9 Ȁ 0.8 compared with 0.5 Ȁ 0.3 kg; P 0.001) and body mass index (in kg/m 2 ; Ҁ0.92 Ȁ 0.25 compared with 0.01 Ȁ 0.11; P ҃ 0.001) and a greater improvement in insulin sensitivity (Ҁ0.22 Ȁ 0.12 compared with 0.47 Ȁ 0.31; P ҃ 0.026) than did the control diet. Conclusion: The improvement in acne and insulin sensitivity after a low-glycemic-load diet suggests that nutrition-related lifestyle factors may play a role in the pathogenesis of acne. However, further studies are needed to isolate the independent effects of weight loss and dietary intervention and to further elucidate the underlying pathophysiologic mechanisms.Am J Clin Nutr 2007;86: 107-15.

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“…11 In British male soldiers older than 20 years, those with acne tended to be heavier. 12 We are not aware of any other studies that have investigated the relationship between acne and BMI. Strengths of this study are the many participants and the high participation rate, and thus its representativeness.…”

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confidence: 99%

A Population-Based Study of Acne and Body Mass Index in Adolescents

Halvorsen¹

2012

Arch Dermatol

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Observations on Acne, Seborrhoea, and Obesity

Cited by 41 publications

References 6 publications

Acne e dieta: verdade ou mito?

Acne e dieta: verdade ou mito?

A low-glycemic-load diet improves symptoms in acne vulgaris patients: a randomized controlled trial

A Population-Based Study of Acne and Body Mass Index in Adolescents

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