Observations on Porphyria Cutanea Tarda

Carbohydrate Metabolism in Porphyria cutanea tarda

“…It is claimed that 25% of male patients are diabetic [1] and that the diabetes may precede [2,6,15, 27] or follow [7, 21] the onset of porphyria cutanea tarda by years. However, it should be noted that Berman and Bielicky' s per centage [2] was based on a review of cases, of ten single, published in the literature and that many investigations on carbohydrate metabolism in porphyria cutanea tarda pa tients have been carried out by non-standardized methods on limited series without adequate control groups.…”

Porphyrin Excretion in Scleroderma (Acrosclerosis)

“…In a series of 34 cases of PCT studied by Brunsting, yellowing and hardening of the exposed skin of the face and back of the neck was commonly observed, especially in men. 1 Tio also noted thickening, yellowing, and deep furrows of the skin. 2 Bolgert and Canivet stated that the confluent atrophic macules secondary to bullae or minor injury resembled scleroderma.…”

Is Porphyria cutanea tarda a Risk Factor in the Development of Hepatocellular Carcinoma?

“…Heavy alcohol consumption is a frequent pre cipitant of PCT, and liver cirrhosis is a common asso ciated finding [6]. Although the potential of cirrhotic tissue to give rise to hepatocellular carcinoma is wellrecognised, several Czechoslovak authors have Wc thank Dr. J.L.…”