Observations on the A2 England influenza epidemic

Vérel, D.; WARRACK, A; Potter, C. W.; Ward, Christopher; Rickards, D.

doi:10.1016/s0002-8703(76)80109-3

Cited by 53 publications

(32 citation statements)

References 16 publications

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“…Influenza may rarely cause myocardial disease and atrial fibrillation [29] directly or indirectly with associated electrolyte disturbances, pneumonia or through a systemic inflammatory response [30]. This inflammatory atherosclerotic hypothesis may not apply to ICH or SAH and the pathobiological relationship between these stroke types and influenza is unclear.…”

Section: Discussionmentioning

confidence: 99%

Relationship between Supra-Annual Trends in Influenza Rates and Stroke Occurrence

Field¹,

Zhu²,

Tarrant

et al. 2004

Neuroepidemiology

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Background: Stroke occurrence appears to be a random event, yet annual and supra-annual periodicity is observed. Recent attention in atherosclerotic disease etiology has focused on infectious and inflammatory mechanisms. Influenza is one such infection that may influence stroke occurrence. Methods: We explored population-based time series data on stroke occurrence and influenza activity. Using Fourier transformation to isolate low-frequency signals in the data, the inverse transformed time series were regressed using Prais-Winsten regression to correct for serially auto-correlated residuals, to assess the relationship between influenza rates and stroke occurrence rates. Results: Changes in the low-frequency components of influenza activity predicted the changes in low-frequency components of the stroke occurrence data with a delay of about 20 weeks. The delay between changes in influenza activity and subsequent stroke activity was different for different stroke types. Overall, the effect size was small with a tripling of the influenza rate associated with about a 6% change in stroke occurrence rate. Conclusions: A small proportion of the patterns of stroke occurrence may be explained by variation in influenza activity. Further evaluation of influenza as a triggering agent in stroke is needed.

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Section: Discussionmentioning

confidence: 99%

Relationship between Supra-Annual Trends in Influenza Rates and Stroke Occurrence

Field¹,

Zhu²,

Tarrant

et al. 2004

Neuroepidemiology

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show abstract

“…Clinical findings in patients with influenza were consistent with typical systemic effects, such as high temperature, muscle pain and fatigue, and also indicated frequent episodes of myocardial ischemia (Greaves et al, 2003;Ison et al, 2005;Paul, 1963;Verel et al, 1976). These results led to the hypothesis that influenza may play a role in triggering cardiovascular events.…”

Section: Introductionmentioning

confidence: 65%

Studies of Nuclex effect under cardiovascular disorders, influenza and acute upper respiratory tract infection

Tkachuk

Швед

Prokopovych

et al. 2013

IJBHR

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Abstract:The obtained results have confirmed the efficacy of Nuclex in terms of normalisation of parameters of coronary reserve, and in terms of elimination of the main signs and symptoms of influenza and acute upper respiratory tract infection (URTI), in particular, normalisation of body temperature, disappearance of headache, catarrhal phenomena, and general fatigue. The decrease in intensity of these signs and symptoms in the study group appeared one to three days earlier than in the control group, and this difference remained significant until the end of treatment. On the 14th day of Nuclex intake influenza A virus H1N1 could not be found by means of PCR in 58.33% of the study group patients, meanwhile in the control group patients the virus was still detectable. The results have clearly demonstrated the significant difference in the treatment efficacy between the control and study groups thus favouring the latter. Nuclex has been proven effective to completely remove the influenza virus from the body.

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“…The first two patients with influenza myocarditis were reported by Finland et al in 1945 (2). Myocarditis as a complication of influenza has been observed frequently since the Asian influenza epidemic of 1957 (3)(4)(5), although few studies have analyzed the prevalence of asymptomatic myocardial injury. It has been noted however, that elderly people, without apparent symptomsof myocarditis, may develop heart failure during the clinical course of influenza.…”

Section: Introductionmentioning

confidence: 99%

Elevated Serum Myosin Light Chain I in Influenza Patients.

et al. 2001

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Objective Myocarditis has been described as a complication of influenza. Patients with influenza mayhave symptoms and abnormal laboratory data (including chest X-ray, electrocardiogram, etc.) suggestive of myocarditis, although few observations have been maderegarding the prevalence of asymptomatic myocardial injury. Weinvestigated whether influenza can produce myocardial injury without cardiac symptoms.

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Observations on the A2 England influenza epidemic

Cited by 53 publications

References 16 publications

Relationship between Supra-Annual Trends in Influenza Rates and Stroke Occurrence

Relationship between Supra-Annual Trends in Influenza Rates and Stroke Occurrence

Studies of Nuclex effect under cardiovascular disorders, influenza and acute upper respiratory tract infection

Elevated Serum Myosin Light Chain I in Influenza Patients.

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