Observations on the Effect of Experimental Endocrine Procedures on the Teratogenic Action of Hypervitaminosis A in the Rat

Cohlan, Sidney Q.; Stone, Shirley M.

doi:10.1159/000239854

Cited by 16 publications

(2 citation statements)

References 5 publications

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“…Although much of the research focused on stage and dose relationships, attention to mechanisms was also evident in a study examining how the variability in malformations might be modulated through the influence of hormones. Cohlan and Stone (1961) examined influences of growth hormone, parathyroidectomy, thymectomy, adrenalectomy, cortisone, or insulin administration on the CNS malformations following excess vitamin A. In the context of reliable induction of CNS malformations, these manipulations did not demonstrate any potentiating or ameliorating effects at the doses used, but the work is important as representative of an early attempt to understand physiologic influences.…”

Section: The 1960s: Cns Malformations Induced By Maternal Hypervitamimentioning

confidence: 99%

The neurobehavioral teratology of retinoids: A 50‐year history

Adams

2010

Birth Defects Research

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This review of the central nervous system (CNS) and behavioral teratology of the retinoids over the last 50 years is a commemorative retrospective organized by decade to show the prominent research focus within each period and the most salient findings. In the 1960s, research focused on the gross CNS malformations associated with exposure and the delineation of dose-response and stage-specific responses in rodent models. Relevant scientific events before and during the 1960s are also discussed to provide the zeitgeist in which the field of neurobehavioral teratology emerged in the 1970s. During this period, studies demonstrated that adverse effects on postnatal behavior could be produced in animals exposed to doses of vitamin A lower than those that were teratogenic or impacted growth. Work during the 1980s showed an overrepresentation of behavioral studies focused on the reliability of screening methods, while the marked effects of human exposure were illustrated in children born to women treated with isotretinoin during pregnancy. The human catastrophe invigorated research during the 1990s, a period when technological advances allowed more elegant examinations of the developing CNS, of biochemical, cellular, and molecular developmental events and regulatory actions, and of the effects of direct genetic manipulations. Likewise, research in the 1990s reflected a reinvigoration of research in neurobehavioral teratology evinced in studies that used animal models to try to better understand human vulnerability. These foci continued in the 2000-2010 period while examinations of the role of retinoids in brain development and lifelong functioning became increasingly sophisticated and broader in scope. This review of the work on retinoids also provides a lens on the more general ontogeny of the field of neurobehavioral teratology. Birth Defects Research (Part A), 2010. © 2010 Wiley-Liss, Inc.

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Section: The 1960s: Cns Malformations Induced By Maternal Hypervitamimentioning

confidence: 99%

The neurobehavioral teratology of retinoids: A 50‐year history

Adams

2010

Birth Defects Research

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“…From these results, they postulated that the teratogenic mechanism was an interference with the carbohydrate metabolism of the mother, placenta or fetus. Their results were challenged by Cohlan & Stone (1961) but supported by Takekoshi (1964), who suggested that the fall in blood thyroxine levels caused by excess vitamin A was an important factor in the teratogenic mechan¬ ism and the reason for the potentiating effect of methylthiouracil.…”

Section: Introductionmentioning

confidence: 99%

An Electron Microscopic Study of the Effects of Hypervitaminosis a on the Maternal-Embryonic Relationship of the Rat at 8 Days of Pregnancy

Morriss¹

1973

Reproduction

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Congenital anomalies induced in normal and adrenalectomized rats by amniocentesis

Kendrick

Feild

1967

Anat. Rec.

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Sprague-Dawley rats, which are not susceptible to the teratogenic effects of adrenalectomy, adienal corticoids, and corticotropin noted in other species, were subjected to amniocentesis and to amnioceutesis plus adrenalectomy.Amniocentesis was shown to be teratogenic when performed at any time between the fourteenth and eighteenth gestational days inclusive, but no malformations occurred either in control fetuses or when amniocentcsi.; was performed on the thirteenth day of gestation. Fetal resorptions were increased following single amniocentesis on any gestational day from the thirteenth to the eighteenth inclusive. The predominant defects induced were cleft palate and limb deformity. Cleft palate occurred only after amniocentesis on the fourteenth, fifteenth, or sixteenth days of gestation, principally on the fifteenth day. However, limb deformity, consisting primarily of malrotation, syndactyly, and varying degrees of agenesis, occurred following single amniocentesis on any day of gestation from the fourteenth to the eighteenth inclusive, but principally on the fifteenth day. Adrenalectomy did not alter significantly either the nature or the incidence of the anomalies induced by amniocentesis.The data indicate that amniocentesis is teratogenic in the rat, and that the adrenal glands arc neither essential for, nor do they exert any detectable influence upon the induction of those malformations.

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Observations on the Effect of Experimental Endocrine Procedures on the Teratogenic Action of Hypervitaminosis A in the Rat

Cited by 16 publications

References 5 publications

The neurobehavioral teratology of retinoids: A 50‐year history

The neurobehavioral teratology of retinoids: A 50‐year history

An Electron Microscopic Study of the Effects of Hypervitaminosis a on the Maternal-Embryonic Relationship of the Rat at 8 Days of Pregnancy

Congenital anomalies induced in normal and adrenalectomized rats by amniocentesis

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