Observations on the mechanically induced differentiation of cartilage from fibrous connective tissue

Scapinelli, Raffaele; Little, K.

doi:10.1002/path.1711010203

Cited by 39 publications

(9 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The presence of chondrocytes, or chondroid metaplasia (Fig. 2), within fibrous tissue such as ligaments or tendons is normally associated with abnormal compression forces 13,21 . According to the literature, the presence of chondrocytes in the six disk specimens in this study is most likely to be the result of abnormal forces applied to displaced disks since chondrocytes do not occur in disks that are not displaced 15,18 .…”

Section: Discussionmentioning

confidence: 99%

The prevalence of osteoarthrosis in cases of advanced internal derangement of the Temporomandibular Joint: a clinical, surgical and histological study

Dimitroulis

2005

International Journal of Oral and Maxillofacial Surgery

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

The prevalence of osteoarthrosis in cases of advanced internal derangement of the Temporomandibular Joint: a clinical, surgical and histological study

Dimitroulis

2005

International Journal of Oral and Maxillofacial Surgery

View full text Add to dashboard Cite

“…First, metaplasia of fibroblasts into chondrocytes could have occurred. For example, studies in tendon have demonstrated that fibroblasts subjected to compressive stress can differentiate into chondrocytes [5,18,23]. Furthermore, Lipson [9] found chondrocytes in human herniated disc, with evidence of fibroblast metaplasia that may be due to compressive stress in these discs.…”

Section: Discussionmentioning

confidence: 99%

Biological and mechanical consequences of transient intervertebral disc bending

et al. 2007

View full text Add to dashboard Cite

Degenerative mechanisms for the intervertebral disc are unclear, particularly those associated with cumulative trauma. This research focuses on how mechanical loading at levels below those known to cause acute trauma can lead to cellular injury. Mouse-tail discs were subjected to static bending for 1 week, then allowed to recover unloaded for 3 weeks and 3 months. Discs were analyzed using histology, in situ hybridization (collagen and aggrecan gene expression), TUNEL assay for apoptotic cell death, and biomechanics. The bent discs demonstrated loss of annular cellularity on the concave (compressed) side, while the nucleus and convex annulus appeared normal. Chondrocyte-like cells were apparent within the inner, concave annulus on the recovered discs, with evidence of proliferation at the annulus/endplate interface. However, annular architecture and biomechanical properties for the recovered discs were not different from controls, suggesting that restoration of physiologic tissue stress prevents the inner annular degradation noted in previous compressioninduced degeneration models. These data demonstrate that cellular injury can be induced by transient compressive stress, and that recellularization is slow in this avascular tissue. Taken together, this suggests that cellular damage accumulation may be an important injury mechanism that is distinct from acute mechanical failure.

show abstract

“…Multiple studies of real tissue in and ex vivo corroborate these ideas, and have found regions of fibrocartilage and bone proliferation corresponding with areas of compressional loading ( Scapinelli & Little, 1970 ; Benjamin & Ralphs, 1997 ; Vogel & Peters, 2005 ). Potential mechanosensitive genes involved in the regulation of embryonic ossification have been identified ( Nowlan, Prendergast & Murphy, 2008 ), though investigation of the role of genetics in sesamoid formation is complex and ongoing.…”

Section: Introductionmentioning

confidence: 92%

Three-dimensional anatomy of the ostrich (Struthio camelus) knee joint

Chadwick

Regnault

Allen

et al. 2014

PeerJ

View full text Add to dashboard Cite

The three-dimensional anatomy of the ostrich (Struthio camelus) knee (femorotibial, femorofibular, and femoropatellar) joint has scarcely been studied, and could elucidate certain mechanobiological properties of sesamoid bones. The adult ostrich is unique in that it has double patellae, while another similar ratite bird, the emu, has none. Understanding why these patellae form and what purpose they may serve is dually important for future studies on ratites as well as for understanding the mechanobiological characteristics of sesamoid bone development. For this purpose, we present a three-dimensional anatomical study of the ostrich knee joint, detailing osteology, ligaments and menisci, and myology. We have identified seven muscles which connect to the two patellae and compare our findings to past descriptions. These descriptions can be used to further study the biomechanical loading and implications of the double patella in the ostrich.

show abstract

Observations on the mechanically induced differentiation of cartilage from fibrous connective tissue

Cited by 39 publications

References 10 publications

The prevalence of osteoarthrosis in cases of advanced internal derangement of the Temporomandibular Joint: a clinical, surgical and histological study

The prevalence of osteoarthrosis in cases of advanced internal derangement of the Temporomandibular Joint: a clinical, surgical and histological study

Biological and mechanical consequences of transient intervertebral disc bending

Three-dimensional anatomy of the ostrich (Struthio camelus) knee joint

Contact Info

Product

Resources

About