Observations on the Pathogenesis of the Pneumonitis Associated with Severe Infections in Other Parts of the Body

Intraabdominal bacterial infections significantly alter regeneration and function of the liver in a rat model of major hepatectomy

“…Afterwards, the cecum was punctured once using a 22-gauge needle, and a small amount of stool was extruded to ensure wound patency. ( 3 ) 6 3 3 6 6 3 6 P H + C L P ( 4 ) 6 3 3 6 6 3 6 At the main intervals (6,24,48, and 96 h), six animals per group were included. In groups 3 and 4, additional intervals with three animals each were included (12,18, and 72 h) for a more precise characterization of the regeneration process.…”

Median lethal needle caliber in two models of experimental sepsis

“…There is also loss of blood supply favoring necrosis and perforation 32 . Since 1968, Clowes argued in favor of digestive tract permeability maintenance as essential to the development of sepsis models in the dog 33 .…”

Standardized Intraabdominal Abscess Formation with Generalized Sepsis: Pathophysiology in the Rat

“…Other methods like ligation of the cecum with or without puncture [4,18,23,27] and isolation and devascularization of ileal segments [8. 10] seem less reliable due to variations in bowel content and technical difficulties, and they have consequently been difficult to reproduce [8,10].…”

“…In order to increase the understanding of the pathophys iology of abdominal abscesses and to facili tate studies of various treatment modalities, there is a growing demand for a reproducible small-animal model. The methods used so far have included puncture and ligation of the cecum [4,18,23,25], isolation and devascu larization of an ileal segment [8,10] as well as injection of endotoxin [7,9,13,20,21.24] or intravenous [1,5,8,[15][16][17] or intraperito neal [3,6,14,19] challenge with living bacte ria. Most of these studies have a death rate of 80-100% within 48 h which make the meth ods less suitable for pathophysiological stud ies.…”