Observations on the Pathology of Ménière's Syndrome

Hallpike, C. S.; Cairns, Hugh

doi:10.1177/003591573803101112

Cited by 203 publications

(126 citation statements)

References 9 publications

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“…In all these cases the saccus endolymphaticus is normal and the utriculus full; so that if there were a communication between the saccus and sacculus, the latter might also be expected to fill. The classical picture of Meniere's disease, first reported by Hallpike and Cairns (1938) demonstrates dilatation of the scala media and sacculus but not of the utriculus or semi-circular canals, again strong suggestive evidence that continuity throughout the endolymph system does not always exist. The third condition, seen in an old dog, shows a normal sacculus, scala media, organ of Corti, etc., but an_atrophic, nonsecretory saccus and collapsed utriculus and semicircular canals on both 707 sides.…”

Section: Fig 8 Microphotograph Of Non-vascular Type Of Papilla Showmentioning

confidence: 94%

Observations on the Circulation in the Cochlea

Seymour

1954

J. Laryngol. Otol.

126

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A STUDY of the circulation in the labyrinth, to be complete, must include an investigation of the fluid circulation. The fluid system in the labyrinth is much more complex than that of the cerebrospinal axis. In the latter, the cerebrospinal fluid, produced by the choroid plexuses, circulates by known anatomical pathways and its main function is the protection of the brain. In the labyrinth, however, there are two separate fluids about whose circulation there remains some doubt, but whose purpose is much more important than mere protection of the inner ear. The endolymph, for example, is essential for the normal metabolic transfers between the blood and the structures on the basilar membrane, for the latter are not provided with blood vessels. The purpose of this paper is to deal, first, with the blood circulation mainly in the spiral ligament of the cochlea, then to consider the fluid systems, and, finally, to try to indicate how departures from the normal physiological states may contribute to pathological findings. Although the peripheral circulation, of which that in the cochlea forms a very small part, has been studied for well over an hundred years, it was not until 1944 that the minute details of the capillary fields were accurately described. Chambers, Zweifach and their co-workers described the presence of a vessel which they called the metarteriole, coursing as a preferential or thoroughfare channel, through the capillary bed from terminal arteriole to venule. Before this date it was generally believed that all vessels between the terminal arteriole and the larger venules were simple endothelial tubes. These workers, however, found that smooth muscle fibres extended along the metarteriole for some distance beyond the terminal arteriole. From the metarteriole and terminal arteriole the true capillaries arise. These are simple endothelial tubes, equipped at their commencement with contractile elements, the precapillary sphincters, which control the flow of blood through them. The papillary arises from the metarteriole | at an angle of 90 0 or less and arches round in a loop to rejoin the mat-1 arteriole at an oblique angle, near the venous end. Chambers, et alia, also demonstrated that the production of Jntercellular fluid occurred from the metarteriole at its arteriolar end and was reabsorbed into the blood stream in accordance with Starling's hypothesis * From the

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Section: Fig 8 Microphotograph Of Non-vascular Type Of Papilla Showmentioning

confidence: 94%

Observations on the Circulation in the Cochlea

Seymour

1954

J. Laryngol. Otol.

126

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“…For many years, the diagnosis of Menière′s disease was a clinical diagnosis based on recurrent episodes of vertigo, hearing loss, aural fullness and/or tinnitus. The pathologic hallmark of Menière′s disease is endolymphatic hydrops . Recently, the development of MRI and the use of intratympanically applied gadolinium‐based contrast agents have enabled the visualisation of endolymphatic hydrops in living patients .…”

Section: Dear Editormentioning

confidence: 99%

Audiologic evaluation of Menière's disease patients one day and one week after intratympanic application of gadolinium contrast agent: Our experience in sixty‐five patients

Louza

Krause

Gürkov

2013

Clinical Otolaryngology

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“…In addition to recurrent vertigo, patients with MD have fluctuating hearing loss, tinnitus, and a sensation of aural fullness (6). Histopathological studies of the temporal bone have revealed endolymphatic hydrops in the affected ears (7)(8)(9). Differential diagnosis of MAV from MD is sometimes hard because patients with MAV could have tinnitus and/or aural fullness during vertigo attacks (10), and a controlled study has provided evidence of the association of MD with migraine (11).…”

Section: Introductionmentioning

confidence: 99%

Does Migraine-Associated Vertigo Share a Common Pathophysiology With Meniere's Disease? Study With Vestibular-Evoked Myogenic Potential

et al. 2009

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To clarify if migraine-associated vertigo (MAV) and Meniere's disease (MD) share a common pathophysiology, vestibular-evoked myogenic potentials (VEMP) were measured in 11 patients with MAV, 11 with unilateral MD and eight healthy subjects. As acoustic stimuli, tone bursts (TB; 250, 500, 1000 and 2000 Hz) were presented. In healthy subjects, 500-Hz TB evoked the largest amplitude. To quantify this tendency, 500-1000 VEMP slope was calculated, and 500-1000 VEMP slope was the smallest on the affected side of MD patients. Among the 11 MD patients, five had significantly decreased 500-1000 VEMP asymmetry (shift of the tuning to 1000 Hz). Three of the 11 MAV patients also showed a significantly decreased 500-1000 VEMP slope. This finding suggests that MAV might share a common pathophysiology with MD. In addition to this finding, four of the other eight MAV patients showed prolonged p13 latencies. This suggests that MAV could consist of patients with different lesion sites.

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Observations on the Pathology of Ménière's Syndrome

Cited by 203 publications

References 9 publications

Observations on the Circulation in the Cochlea

Observations on the Circulation in the Cochlea

Audiologic evaluation of Menière's disease patients one day and one week after intratympanic application of gadolinium contrast agent: Our experience in sixty‐five patients

Does Migraine-Associated Vertigo Share a Common Pathophysiology With Meniere's Disease? Study With Vestibular-Evoked Myogenic Potential

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