Observations on the pharmacological properties of inflammatory exudate

Atkinson, David; Boura, A. L. A.; Hicks, R.

doi:10.1016/0014-2999(69)90045-4

Cited by 27 publications

(19 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Robinson & Robson (1964) showed that the plasma obtained from adrenalectomized rats with implanted sponges exerted anti-inflammatory activity, measured against cotton pellet granuloma and that an implanted sponge reduced the amount of granulation tissue deposited in the same animal. Billingham et al (1969) (Atkinson et aL, 1969;Atkinson, Whittle & Hicks, 1971 ), as suggested by Billingham et aL (1969).…”

Section: Nsmentioning

confidence: 60%

“…(Winter, Risley & Nuss, 1962) The activity of plasma samples obtained from Sprague-Dawley rats was determined in similar rats using the carrageenin paw oedema method described by Atkinson, Boura & Hicks (1969). The samples were administered either i.p or s.c. 1 h before the subplantar injection of carrageenin (0.05 ml of a 1% w/v suspension); the increase in left hind paw volume was measured 3 h later.…”

Section: Animalsmentioning

confidence: 99%

See 1 more Smart Citation

The Possible Occurrence of Endogenous Anti‐inflammatory Substances in the Blood of Injured Rats

Atkinson¹,

Hicks

1975

British J Pharmacology

Self Cite

View full text Add to dashboard Cite

1 Using the carrageenin rat paw oedema test as an assay, an attempt has been made to confirm the presence of anti-inflammatory activity in the blood of rats with a chronic inflammatory lesion induced by a polyester sponge, and to relate such activity to the systemic anti-inflammatory effect exerted in situ by the lesion. In addition, plasma from rats given acetic acid intraperitoneally has been examined for anti-inflammatory properties. 2 The activity of serum obtained from sponge-bearing adrenalectomized Wistar rats did not differ significantly from that obtained from animals without implants. Furthermore, implanted sponges exerted no systemic anti-inflammatory effect. 3 Similar experiments were performed in sponge-bearing adrenalectomized Sprague-Dawley rats, plasma instead of serum being examined for anti-inflammatory activity. The plasma removed from such animals possessed no anti-inflammatory activity, whilst implanted sponges exerted a small, yet significant, systemic inhibitory effect. 4 When the irritancy of sponge implants was augmented with croton oil, more marked systemic anti-inflammatory effects were observed. However, the plasma obtained from rats injured in this manner exerted no anti-inflammatory effect. 5 No anti-inflammatory activity could be detected in plasma samples obtained from rats treated with doses of acetic acid capable of producing pronounced systemic anti-inflammatory effects. 6 It was concluded that the induction of these inflammatory lesions in rats does not appear to lead to a detectable release of endogenous anti-inflammatory substances into the circulation.

show abstract

Section: Nsmentioning

confidence: 60%

Section: Animalsmentioning

confidence: 99%

The Possible Occurrence of Endogenous Anti‐inflammatory Substances in the Blood of Injured Rats

Atkinson¹,

Hicks

1975

British J Pharmacology

Self Cite

View full text Add to dashboard Cite

show abstract

“…GOLDSTEIN et al [20], using a carrageenin 'abscess method in rats, showed that genuine anti-inflammatory agents exert their activity after both systemic and local administration whereas irritants do so only after systemic administration. The differential activity of irritants and anti-inflammatory agents given locally has also been observed using paw oedema models [7,8,21]. However, it should be noted that a high local concentration of fenclofenac, unlikely to be achieved following oral administration, was required to produce a local anti-inflammatory effect.…”

Section: Discussionmentioning

confidence: 88%

“…Acute anti-inflammatory activity was assessed using a method based on those described previously [6,7]. Male rats (150-190 g) were used and the drugs on test were administered orally 1 hour prior to the subplantar carrageenin injection.…”

Section: Carrageenin-induced Paw Oedemamentioning

confidence: 99%

Anti-inflammatory and related properties of 2-(2,4-dichlorophenoxy)phenylacetic acid (fenclofenac)

Atkinson

Leach

1976

Agents and Actions

View full text Add to dashboard Cite

Fenclofenac was shown to possess anti-inflammatory, antinociceptive and antipyretic properties as measured by tests in rats that detect clinically active compounds. In a chronic test for assessing anti-inflammatory activity (established adjuvant arthritis), it was approximately equipotent to alclofenac, fenoprofen calcium and phenylbutazone, more potent than acetylsalicylic acid and ibuprofen, but was less potent than diclofenac sodium, indomethacin, ketoprofen and naproxen. In contrast, the potency of fenclofenac in acute tests for anti-inflammatory, antinociceptive and anti-pyretic activity was generally lower, the drug being approximately equipotent to acetylsalicylic acid in such tests. The anti-inflammatory activity of fenclofenac was not mediated via the pituitary-adrenal axis or a counter-irritant action. Fenclofenac was shown to have remarkably low gastric ulcerogenic potential, both acutely and chronically.

show abstract

“…Inflammatory exudates obtained by implantation of polyester sponges in rats have been shown to be anti-inflammatory (Robinson & Robson, 1966) and the active component is known to be a protein (Billingham, Robinson & Robson, 1969). The mechanism of action of these proteins is not known but mechanisms suggested include lysosomal stabilization (Doherty & Robinson, 1976a), interaction with the complement system (Doherty & Robinson, 1976b) or by a counter irritant mechanism (Atkinson, Boura & Hicks, 1969).…”

mentioning

confidence: 99%

PROCEEDINGS OF THE British Pharmacological Society 4th–6th April, 1979

1979

British J Pharmacology

View full text Add to dashboard Cite

Observations on the pharmacological properties of inflammatory exudate

Cited by 27 publications

References 8 publications

The Possible Occurrence of Endogenous Anti‐inflammatory Substances in the Blood of Injured Rats

The Possible Occurrence of Endogenous Anti‐inflammatory Substances in the Blood of Injured Rats

Anti-inflammatory and related properties of 2-(2,4-dichlorophenoxy)phenylacetic acid (fenclofenac)

PROCEEDINGS OF THE British Pharmacological Society 4th–6th April, 1979

Contact Info

Product

Resources

About