Observer reproducibility of results from a low-dose 123I-metaiodobenzylguanidine cardiac imaging protocol in patients with heart failure

Abstract

The present study showed a high observer reproducibility of planar H/M ratios and SPECT defect scores using a low-dose (123)I-MIBG cardiac imaging protocol in patients with HF.

123I-MIBG SPECT for Evaluation of Patients with Heart Failure

“…Pellegrino et al demonstrated excellent observer reproducibility of a visual evaluation of 123 I-MIBG SPECT studies with a low-dose 123 I-MIBG protocol (63). Nevertheless, it can be challenging to evaluate 123 I-MIBG SPECT studies visually, especially in patients with HF and a global reduction in uptake (35).…”

123I-mIBG: Simplicity and reproducibility

“…24 A subsequent study by Pellegrino et al also demonstrated high intra-observer and inter-observer reproducibility among experienced readers. 25 The study by Bateman et al in this volume of the Journal addresses the second factor. 26 It explores the reproducibility of mIBG H/M ratio among clinically stable New York Heart Association classes II-III patients with left ventricular ejection fraction B 35%.…”

Cardiac neuronal imaging with 123I-meta-iodobenzylguanidine in heart failure: implications of endpoint selection and quantitative analysis on clinical decisions

“…Among these, the norepinephrine analogue meta-iodobenzylguanidine (MIBG) labelled with 123 I has been widely used and validated as a marker of adrenergic neuron function [2][3][4]. The first study addressing the prognostic value of 123 I-MIBG imaging in heart failure (HF) was that of Merlet et al [5] in 90 patients suffering from either ischaemic or idiopathic cardiomyopathy.…”