The study examined models of marijuana (n = 309) and alcohol (n = 731) problems. Impulsivity was directly associated with both marijuana- and alcohol-related problems. Negative mood regulation expectancies were indirectly associated with marijuana problems through coping motives. Sensation seeking was indirectly associated with alcohol problems through enhancement motives. Affect lability and negative affect were indirectly associated with alcohol problems though coping motives. In both models, coping motives were directly associated with use-related problems. A multigroup analysis indicated that the association between negative affect and coping motives as well as use and problems was stronger among participants using both alcohol and marijuana relative to alcohol only. Enhancement motives were a stronger predictor of alcohol use among participants using alcohol only.

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1-123 metaiodobenzylguanidine (MIBG) is a new radiopharmaceutical with properties that allow the characterization of the sympathetic innervation of several organ systems. In this study, we used MIBG with tomographic imaging to evaluate noninvasively the differences in myocardial sympathetic innervation in 14 healthy volunteers and 16 patients with severe dilated cardiomyopathy (CM). Initial (15-minute) images demonstrated no significant differences in MIBG concentration in the hearts of patients with CM and of healthy volunteers. However, the myocardial retention of MIBG was significantly reduced in the patients with CM. Expressed as the percent washout from 15 to 85 minutes, the patients with CM had a 28 ± 12% washout rate compared with 6 8% in the controls (p

The diagnostic accuracy of thallium SPECT myocardial perfusion imaging is lower in women than in men. Most of the difference appears to be due to smaller left ventricular chamber size in women, although a small residual gender effect in smaller heart sizes cannot be entirely excluded. It is proposed that the most likely cause for this difference is the relatively greater effect of imaging blurring on smaller hearts.

No abstract