Obsessive-Compulsive Disorder With Rheumatological and Inflammatory Diseases: A Systematic Review

Alsheikh, Ahmed; Alsheikh, Maram M

doi:10.7759/cureus.14791

Cited by 6 publications

(4 citation statements)

References 24 publications

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“…Additionally, OCD is known to be associated with elevated levels of inflammatory markers such as interleukin (Rao et al 2015) and TNF-α (Cappi et al 2012). Therefore, our results are indicative of other studies in the literature that inflammation may contribute significantly to the pathogenesis of OCD (Alsheikh and Alsheikh 2021). OCD was also associated with ADDADHD (Figure 8), and reports suggest that both conditions exhibit a high degree of association and might involve abnormalities in similar brain networks (Brem et al 2014).…”

Section: Discussionsupporting

confidence: 89%

“…Our study also suggests that OCD is significantly associated with RA in young subjects (Figure 8). While OCD is a psychiatric condition (Alsheikh and Alsheikh 2021), RA is considered to be a rheumatological and autoimmune condition (Hammond et al 2019; Sudhakar et al 2023). Endorsing our observations, previous literature suggests that OCD may encompass an inflammatory origin (Mataix-Cols et al 2018; Alsheikh and Alsheikh 2021).…”

Section: Discussionmentioning

confidence: 99%

“…While OCD is a psychiatric condition (Alsheikh and Alsheikh 2021), RA is considered to be a rheumatological and autoimmune condition (Hammond et al 2019; Sudhakar et al 2023). Endorsing our observations, previous literature suggests that OCD may encompass an inflammatory origin (Mataix-Cols et al 2018; Alsheikh and Alsheikh 2021). In a nationwide study of Swedish individuals (Mataix-Cols et al 2018), OCD was associated with an increased number of observing numerous autoimmune conditions.…”

Section: Discussionmentioning

confidence: 99%

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Exploring Comorbidity Networks in Mild Traumatic Brain Injury Subjects through Graph Theory: A Traumatic Brain Injury Model Systems Study

Mehta,

Sudhakar

2024

Preprint

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Traumatic brain injuries (TBIs) are characterized by myriad comorbidities that affect the functioning of the affected individuals. The comorbidities that TBI subjects experience span a wide range, ranging from psychiatric diseases to those that affect the various systems of the body. This is compounded by the fact that the problems that TBI subjects face could span over an extended period post-primary injury. Further, no drug exists to prevent the spread of secondary injuries after a primary impact. In this study, we employed graph theory to understand the patterns of comorbidities after mild TBIs. Upon application of network analysis and a novel clustering algorithm, we discovered interesting associations between comorbidities in young and old subjects with the condition. Specifically, bipolar disorder was seen as related to cardiovascular comorbidities, a pattern that was observed only in the young subjects. Similar associations between obsessive-compulsive disorder and rheumatoid arthritis were observed in young subjects. Psychiatric comorbidities exhibited differential associations with non-psychiatric comorbidities depending on the age of the cohort. The study results might have implications for effective surveillance and the management of comorbidities post mild TBIs.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Exploring Comorbidity Networks in Mild Traumatic Brain Injury Subjects through Graph Theory: A Traumatic Brain Injury Model Systems Study

Mehta,

Sudhakar

2024

Preprint

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“…According to studies, GM-CSF levels are different in people with OCD compared to healthy controls. GM-CSF levels are higher in OCD patients in several studies, pointing to a pro-inflammatory scenario 28 , 29 . The increase in inflammation and the modulation of immunological responses have been linked to GM-CSF.…”

Section: Introductionmentioning

confidence: 99%

Association of granulocyte macrophage colony-stimulating factor and interleukin-17 levels with obsessive–compulsive disorder: a case–control study findings

Sarker,

Qusar,

Islam

et al. 2023

Sci Rep

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Obsessive–compulsive disorder (OCD) is a mental condition that affects many people and is characterized by recurring obsessions and compulsions. It significantly impacts individuals’ ability to function ordinarily daily, affecting people of all ages. This study aimed to investigate whether or not the cytokines granulocyte macrophage colony-stimulating factor (GM-CSF) and interleukin-17 (IL-17) are involved in the pathophysiology of OCD. A case–control study with 50 OCD patients and 38 healthy volunteers served as the controls for this investigation. The levels of GM-CSF and IL-17 in the serum of both groups were measured with enzyme-linked immunosorbent assay (ELISA) kits. In addition, the sociodemographic characteristics of the population under study were studied. Based on the findings of this study, OCD patients had significantly elevated levels of IL-17 than the controls, it appears that there may be a function for IL-17 in the pathophysiology of OCD. It was also discovered that the severity of OCD and IL-17 levels had a significant positive correlation. On the other hand, when comparing the levels of GM-CSF, there was no significant difference between the patients and the controls. This study provides evidence supporting the involvement of cytokine IL-17 in the pathophysiology of OCD. This study suggests IL-17 as a diagnostic biomarker for OCD and adds to our knowledge of the function that the immune system plays in this condition.

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Common mental disorders in South Asian patients with systemic sclerosis: a CIS-R-based cross-sectional study

et al. 2022

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Obsessive-Compulsive Disorder With Rheumatological and Inflammatory Diseases: A Systematic Review

Cited by 6 publications

References 24 publications

Exploring Comorbidity Networks in Mild Traumatic Brain Injury Subjects through Graph Theory: A Traumatic Brain Injury Model Systems Study

Exploring Comorbidity Networks in Mild Traumatic Brain Injury Subjects through Graph Theory: A Traumatic Brain Injury Model Systems Study

Association of granulocyte macrophage colony-stimulating factor and interleukin-17 levels with obsessive–compulsive disorder: a case–control study findings

Common mental disorders in South Asian patients with systemic sclerosis: a CIS-R-based cross-sectional study

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