Obstetric complications and eating disorders: A replication study

Tenconi, Elena; Santonastaso, Paolo; Monaco, Francesco; Favaro, Angela

doi:10.1002/eat.22304

Cited by 21 publications

(38 citation statements)

References 33 publications

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“…Several null associations in this study are concordant with previous research findings, including AN and breech delivery (Tenconi, Santonastaso, Monaco, & Favaro, ), preterm (Favaro et al, ; Nicholls & Viner, ), and small‐for‐gestational‐age (Tenconi et al, ), as well as BN and maternal age (Goodman et al, ), paternal age (Goodman et al, ), diabetes during pregnancy (Favaro et al, ), preeclampsia (Favaro et al, ), delivery method (Favaro et al, ), gestational age (Goodman et al, ), and birth length (Favaro et al, ; Goodman et al, ; Nicholls & Viner, ; Tenconi et al, ). Previously identified significant and positive associations between AN and maternal age (Goodman et al, ), paternal age (Javaras et al, ), diabetes during pregnancy (Favaro et al, ), preeclampsia (Favaro et al, ), breech delivery (Lindberg & Hjern, ), instrumental delivery (Cnattingius, Hultman, Dahl, & Sparén, ), particular obstetric complications (Cnattingius et al, ; Favaro et al, ; Lewis & Murray, ; Tenconi et al, ), and preterm (Cnattingius et al, ; Lindberg & Hjern, ), and negative associations with gestational age (Cnattingius et al, ; Foley et al, ; Goodman et al, ) and postterm (Lindberg & Hjern, ) were not replicated in this study. Previously identified associations between prenatal and perinatal outcomes and AN and BN are drawn from single studies, which often fail to control for multiple testing.…”

Section: Discussionsupporting

confidence: 92%

Prenatal and perinatal risk factors for eating disorders in women: A population cohort study

Watson

Diemer

Zerwas

et al. 2019

Intl J Eating Disorders

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Objective: The fetal programming model hypothesizes that developmental programming in utero and in early life induces adaptations that predetermine the adult phenotype. This study investigated whether prenatal/perinatal complications are associated with lifetime eating disorders in women.Method: Participants included 46,373 adult women enrolled in the Norwegian Mother and Child Cohort Study (den norske Mor & barn-undersøkelsen [MoBa]).MoBa mothers and their mothers (MoBa grandmothers) were the focus of the current study. MoBa mothers with lifetime eating disorders were compared to a referent group.Results: MoBa mothers who weighed more at birth (birth weight, adjusted odds ratio[OR] = 1.14; 95% confidence interval [CI]: 1.10-1.19) or were born large-for-gestational-age (adjusted OR = 1.39; 95% CI: 1.27-1.52) were more likely to develop binge-eating disorder in later life. MoBa mothers who weighed less at birth were more likely to develop anorexia nervosa (birth weight, adjusted OR = 0.88; 95% CI: 0.81-0.95). Bulimia nervosa and purging disorder (PD) were not significantly predicted by the prenatal and perinatal factors examined.Discussion: Results of this study, which include the first known investigation of prenatal and perinatal factors in binge-eating disorder and PD, suggest that fetal programming may be relevant to the development of anorexia nervosa and binge-eating disorder. Future genetically informative research is needed to help disentangle

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Section: Discussionsupporting

confidence: 92%

Prenatal and perinatal risk factors for eating disorders in women: A population cohort study

Watson

Diemer

Zerwas

et al. 2019

Intl J Eating Disorders

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show abstract

“…While genetic factors play a major role, there are also a number of environmental risk factors for anorexia nervosa including, maternal factors, obstetric, and neonatal complications (Goodman, Heshmati, Malki, & Koupil, ; Krug, Taborelli, Sallis, Treasure, & Micali, ; Tenconi, Santonastaso, Monaco, & Favaro, ). Preeclampsia, placental infarction, preterm birth, multiple birth, birth trauma, and early feeding difficulties have been suggested to be predictors of anorexia nervosa in adolescence (Cnattingius, Hultman, Dahl, & Sparén, ; Goodman et al, ; Tenconi et al, ).…”

Section: Introductionmentioning

confidence: 99%

Association between maternal body mass index in early pregnancy and anorexia nervosa in daughters

Razaz

Cnattingius

2018

Intl J Eating Disorders

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“…This question is of some importance since evidence about AN having a possible neurodevelopmental origin is increasing: the disorder has its onset during adolescence [Favaro et al, 2009], is associated with an excess of left-handedness , specific neuropsychological impairments [Lopez et al, 2008;Roberts et al, 2007;Tenconi et al, 2010], and subtle neurological abnormalities [Gillberg et al, 1994]. In addition, prenatal and perinatal risk factors that have been implicated in other neurodevelopmental psychiatric disorders, such as autism and schizophrenia, seem to increase the risk of developing AN [Favaro et al, 2006[Favaro et al, , 2014Tenconi et al, 2015]. Pregnancy and perinatal complications, for example, are twice more likely to occur in patients with AN than in healthy women [Favaro et al, 2006] and the presence of dysmaturity signs at birth (i.e., being small for gestational age or being hyporeactive/hypothermic at birth) are associated with an increased vulnerability to subsequent traumatic events .…”

Section: Introductionmentioning

confidence: 99%

Gyrification brain abnormalities as predictors of outcome in anorexia nervosa

Favaro

Tenconi

Degortes

et al. 2015

Human Brain Mapping

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Gyrification brain abnormalities are considered a marker of early deviations from normal developmental trajectories and a putative predictor of poor outcome in psychiatric disorders. The aim of this study was to explore cortical folding morphology in patients with anorexia nervosa (AN). A MRI brain study was conducted on 38 patients with AN, 20 fully recovered patients, and 38 healthy women. Local gyrification was measured with procedures implemented in FreeSurfer. Vertex-wise comparisons were carried out to compare: (1) AN patients and healthy women; (2) patients with a full remission at a 3-year longitudinal follow-up assessment and patients who did not recover. AN patients exhibited significantly lower gyrification when compared with healthy controls. Patients with a poor 3-year outcome had significantly lower baseline gyrification when compared to both healthy women and patients with full recovery at follow-up, even after controlling for the effects of duration of illness and gray matter volume. No significant correlation has been found between gyrification, body mass index, amount of weight loss, onset age, and duration of illness. Brain gyrification significantly predicted outcome at follow-up even after controlling for the effects of duration of illness and other clinical prognostic factors. Although the role of starvation in determining our findings cannot be excluded, our study showed that brain gyrification might be a predictor of outcome in AN. Further studies are needed to understand if brain gyrification abnormalities are indices of early neurodevelopmental alterations, the consequence of starvation, or the interaction between both factors.

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Obstetric complications and eating disorders: A replication study

Abstract: Our study provides further evidence of the role of OCs as putative risk factors for the development of eating disorders, showing different pathways between AN and BN.

Cited by 21 publications

References 33 publications

Prenatal and perinatal risk factors for eating disorders in women: A population cohort study

Prenatal and perinatal risk factors for eating disorders in women: A population cohort study

Association between maternal body mass index in early pregnancy and anorexia nervosa in daughters

Gyrification brain abnormalities as predictors of outcome in anorexia nervosa

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