Obstetric predictors of placental/umbilical cord blood volume for transplantation

Jones, Johannes; Stevens, Cladd E.; Rubinstein, Pablo; Robertazzi, Robert R.; Kerr, Angela; Cabbad, Michael

doi:10.1067/mob.2003.19

Cited by 76 publications

(117 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Obviously, erythroblasts, as differentiated cells, are not capable of mediating engraftment, but their increase in fetal/neonatal blood usually portends the presence of higher concentrations of HSCs and progenitor cells. Thus, nucleated erythroid cell numbers correlate in multivariate analyses with the probability of engraftment and its speed 27,29 as do monocyte numbers, but not lymphocyte or neutrophil counts (as measured by clinical hematology analyzers). 27 In a multivariate analysis of 1213 single-unit grafts (NCBP, unpublished data, 2004), including the transplant's neutrophils, lymphocytes, monocytes and nucleated erythrocytes, these cell types were numerically associated with the following relative risks of engraftment (and corresponding probabilities) respectively, 0.998 (P ¼ 0.3), 0.994 (P ¼ 0.08), 1.047 (Po0.001) and 1.015 (Po0.001) Thus, only the monocytes (as defined) and nucleated erythrocytes (of the classical cell types in human CB) are positively associated with engraftment.…”

Section: Collected Cord Blood: Cells and Hematopoietic Potencymentioning

confidence: 99%

“…27 Mother's informed consent General consensus holds that a valid informed consent must be obtained before the onset of labor when the placental blood is to be obtained during its third phase (see above). Informed consent may be obtained after delivery when blood is collected from the delivered placenta, but, in this case, the mother must be informed of her right to direct the program not to collect, retain or test the unit and/or to discard it without further ado.…”

Section: Cord Blood Harvesting Techniquementioning

confidence: 99%

See 1 more Smart Citation

Cord blood banking for clinical transplantation

Rubinstein

2009

Bone Marrow Transplant

View full text Add to dashboard Cite

Cord blood (CB) stem and progenitor cells from related donors have been transplanted for past 20 years and from unrelated donors issued by public CB banks for 16 years. This brief look at public CB banking highlights aspects of its current status to suggest that accomplishing the currently required tasks, though no small undertaking, is not enough: much remains to be contributed. CB banking started in the 1930s, collecting blood for transfusion and showed that CB could be effectively collected, stored and administered intravenously without negative consequences. The realization that it contains hematopoietic 'stem' cells (actually, colony-forming units) followed discoveries elsewhere in hematopoiesis research, while HLA and unrelated BMT were being investigated. Progress in the exploration of ethnically stratified HLA allele frequencies, together with plausible neonatal (partial) immunological tolerance, seemed to predict initially frequent, unavoidable, but sufficiently tolerable HLA mismatching with CB grafts. Gluckman et al. and Boyse et al. proved that HLA-identical sibling CB grafts led to definitive engraftment. Technical developments in processing and freezing enabled public banks to accumulate large inventories and to supply grafts that could succeed despite major HLA incompatibility and low cell doses and provide hope for universal access to unrelated-donor transplantation. Public CB banking has thrived worldwide. Regulation and accreditation defined Good Tissue Practice in the CB banking environment and provided accepted do's, don't's and how to's. Startling advances continue to be made, not only technical, but including the description of molecular regulation in the function of natural killer and other cells involved in allogeneic recognition that will have dramatic effects and will permit further improvement in CB selection and use.

show abstract

Section: Collected Cord Blood: Cells and Hematopoietic Potencymentioning

confidence: 99%

Section: Cord Blood Harvesting Techniquementioning

confidence: 99%

Cord blood banking for clinical transplantation

Rubinstein

2009

Bone Marrow Transplant

View full text Add to dashboard Cite

show abstract

“…Further, some of these factors are unknown until delivery. 80 Thus, we can think of TNC count as conditionally random and therefore difficult for CBBs to target perfectly. Although some have argued that cord blood acquisition costs are significantly higher than other sources of HSCs, we were unable to examine this empirically due to lack of data.…”

Section: Cord(blood(procurement(costs(have(increased(relative(to(altementioning

confidence: 99%

“…[78][79][80][81][82] Collection costs include costs of recruiting donors, collection kit supplies, and labor costs. These costs may vary based on the recruitment efforts conducted, as well as whether the bank uses volunteer CBU collectors (which is most common), or whether it employs its own CBU collectors.…”

Section: Variable%and%fixed%costs%of%cord%blood%banking%%mentioning

confidence: 99%

Challenges to the Sustainability of the U.S. Public Cord Blood System

Kapinos¹,

Briscombe²,

Gračner³

et al. 2017

View full text Add to dashboard Cite

“…Por otro lado, se encontró, que de las variables neonatales, la longitud del cordón fue la única que se correlacionó con el recuento total de células nucleadas y no hubo ninguna otra correlación entre las demás variables maternas o neonatales analizadas como vía del parto, peso materno, edad gestacional, peso de placenta, peso del bebé datos que contrastan en cuanto a que el peso del neonato al momento del nacimiento es el principal factor neonatal que afecta el Numero de CD34+ y Recuento de células nucleadas (7)(8)(9)(10)22,(26)(27)(28)(29)(30)(31). Llama la atención el hecho que se hubiera encontrado correlación solamente entre la longitud del cordón umbilical y el recuento total de células nucleadas y no también con el recuento de células CD34+, teniendo en cuenta, y según los resultados del presente estudio, la existencia de correlación entre estos dos marcadores de calidad, inquietudes que valen la pena tener en cuenta para próximas investigaciones.…”

Section: Discussionunclassified

Correlación entre características físicas neonatales y maternas con el recuento total de células nucleadas y de células CD34+ por microlitro en sangre de cordón umbilical

et al. 2015

View full text Add to dashboard Cite

ResumenIntroducción: La sangre de cordón umbilical (SCU) ha sido reconocida como una fuente de células madre hematopoyéticas. Múltiples estudios han sido realizados con el propósito de determinar variables maternas y neonatales que afecten el volumen, el recuento total de células nucleadas y de células CD34+. El presente estudio correlaciona variables maternas y neonatales con el recuento total de células nucleadas y de CD34+ medidas en µL (microlitro). Materiales y Métodos:Estudio correlacional en el que se analizaron 50 muestras de sangre de cordón umbilical de gestantes atendidas en dos IPS, una de Bogotá y otra de Ubaté, (Cundinamarca), durante un período de 7 meses del año 2013. La selección de estas muestras fue basada en un muestreo no probabilístico. Se calculó el coeficiente de correlación de Pearson con su respectiva significancia estadística entre las variables cuantitativas de la madre y del neonato, y el volumen, el recuento de células CD34+ y el recuento total de células nucleadas por µL. Resultados:Se encontró correlación positiva entre la longitud del cordón y el recuento total de células nucleadas. Así mismo entre el volumen inicial de la muestra y el recuento total de células nucleadas y el recuento de células CD34+ en µL y en mL (mililitro). Discusión:Múltiples estudios se han desarrollado entorno a la búsqueda de variables maternas y neonatales que afectan la calidad de la muestra. En Colombia no se habían descrito las correlaciones encontradas en el presente estudio. Es por ello, que el desarrollo de nuevos estudios con diseños analíticos será enriquecedor. Palabras claves: Células madre, antígeno CD34+, trasplante de células madre de sangre de cordón umbilical (SCU), neonatal, materno, factores de riesgo. CORRELATION BETWEEN NEONATAL AND MATERNAL PHYSICAL CHARACTERISTICS WITH TOTAL NUCLEATED CELL COUNT AND CELL COUNT PER MICROLITER CD34+ IN CORD BLOOD AbstractBackground: The cord blood has been recognized as a source of hematopoietic stem. Multiple studies have been conducted in order to determine maternal and neonatal variables that affect the volume, total nucleated cell count and CD34+ cells. This study correlated maternal and neonatal variables with the total nucleated cell count and CD34+ cells measured by µL. Materials and methods: Correlational study in which 50 samples of umbilical cord blood were analyzed of pregnant women at two health institutions, one at Bogotá and the other one at Ubaté, Cundinamarca, for a period of seven months of 2013. The selection of these samples was based on a non-probability sample. The Pearson correlation coefficient was calculated with their respective statistical significance between quantitative variables of mother and newborn, and the volume, the count of CD34+ cells and the total nucleated cell count measured by µL. Results:Positive correlation between the length of the umbilical cord and the total nucleated cell count was found. Similarly, correlation between total nucleated cell count with the initial volume and count of CD34+ cells in µL and m...

show abstract

Obstetric predictors of placental/umbilical cord blood volume for transplantation

Cited by 76 publications

References 12 publications

Cord blood banking for clinical transplantation

Cord blood banking for clinical transplantation

Challenges to the Sustainability of the U.S. Public Cord Blood System

Correlación entre características físicas neonatales y maternas con el recuento total de células nucleadas y de células CD34+ por microlitro en sangre de cordón umbilical

Contact Info

Product

Resources

About