Obstetrical condition and neonatal neurological morbidity. An analysis with the help of the optimality concept

Touwen, B. C. L.; Huisjes, H.J.; Zee, A.D. Jurgens-V.D.; Eendenburg, M.E.C. Bierman-van; Smrkovsky, M; Olinga, A.A.

doi:10.1016/0378-3782(80)90027-4

Cited by 127 publications

(55 citation statements)

References 4 publications

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“…For the latter, we used the 74 variables of the OOS, ranging from the parents' socioeconomic status and health condition to the infant's condition immediately after birth. The sum of all items having a value within a predefined optimal range forms the OOS for an infant (25). We used the information obtained from the OOS both at the single-item level where the items were dichotomized into optimal and nonoptimal categories and in the form of the sum of all items of the OOS.…”

Section: Methodsmentioning

confidence: 99%

Relationship Between Umbilical Cord Essential Fatty Acid Content and the Quality of General Movements of Healthy Term Infants at 3 Months

Bouwstra¹,

Dijck-Brouwer²,

Décsi

et al. 2006

Pediatr Res

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Prenatal essential fatty acid (EFA) status might be an important factor in the development of the central nervous system (CNS). The aim of the present study was to evaluate the relationship between the fatty acid compositions of the umbilical blood vessels at birth, used as a proxy of prenatal EFA status, and quality of general movements (GMs) at 3 mo. Umbilical artery and vein fatty acid compositions were investigated in a mixed group of breastfed infants and infants fed with formula with or without long-chain polyunsaturated fatty acid (LCPUFA) supplementation. At the age of 3 mo, video assessment of the quality of GMs was performed to evaluate neurologic condition. The quality of GMs was scored by assessing the degree of variation, complexity, and fluency. Outcomes were classified as normal-optimal, normal suboptimal, mildly abnormal, and definitely abnormal movements. Information on potential confounders, including the type of postnatal feeding, was collected prospectively. Associations between fatty acid status at birth and quality of GMs were investigated, and multinomial logistic regression analyses were carried out. None of the infants showed definitely abnormal movements. Infants with mildly abnormal GMs had a lower EFA index, lower arachidonic acid (AA) content, higher total n-9 fatty acid, and higher total monounsaturated fatty acid (MUFA) content in the umbilical artery compared with infants with normal GMs. Multivariate analyses confirmed these findings. We conclude that mildly abnormal GMs are associated with a less favorable EFA status in the umbilical artery. (Pediatr Res 59: 717-722, 2006)

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Section: Methodsmentioning

confidence: 99%

Relationship Between Umbilical Cord Essential Fatty Acid Content and the Quality of General Movements of Healthy Term Infants at 3 Months

Bouwstra¹,

Dijck-Brouwer²,

Décsi

et al. 2006

Pediatr Res

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“…During the last month of pregnancy, mothers were visited at home for an explanation of the study protocol. The obstetric, delivery, and neonatal conditions were assessed by means of the obstetrical optimality scale (16). To establish an optimal study population, only infants born at term (37 to 42 wk of gestation) without congenital anomalies or diseases were included.…”

Section: Methodsmentioning

confidence: 99%

Effects of Dioxins and Polychlorinated Biphenyls on Thyroid Hormone Status of Pregnant Women and Their Infants

et al. 1994

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Dioxins [polychlorinated dibenzo-p-dioxins (PCDD), dibenzofurans (PCDF)] and polychlorinated biphenyls (PCB) are potentially hazardous compounds. Animal studies have demonstrated that PCDD, PCDF, and PCB can alter thyroid hormone homeostasis. We investigated thyroid hormone levels in 105 mother-infant pairs. To estimate maternal and infant exposure, four nonplanar PCB congeners were measured in maternal plasma during the last month of pregnancy and in umbilical cord plasma. Seventeen PCDD and PCDF congeners, three planar PCB congeners, and 23 nonplanar PCB congeners were measured in human milk. Higher PCDD, PCDF, and PCB levels in human milk, expressed as toxic equivalents, correlated significantly with lower plasma levels of maternal total triiodothyronine and total thyroxine, and with higher plasma levels of TSH in the infants in the 2nd wk and 3rd mo after birth. Infants exposed to higher toxic equivalents levels had also lower plasma free thyroxine and total thy-PCDD and PCDF, summarized as dioxins, are tricyclic aromatic compounds. Because the number of chlorine atoms can vary between one and eight, there are potentially 75 different PCDD and 135 PCDF congeners. They are mainly formed as by-products during the synthesis of organochlorine chemicals and during the combustion of municipal and hazardous waste (1). PCB are a compilation of 209 possible congeners with different chlorine substitutions. Because of their unique physical properties and chemical stability, mixtures were used for diverse

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“…and perinatal circumstances were recorded by means of a questionnaire with 72 representative items. The number of items that fulfilled predefined optimality criteria [8] was used as an obstetrical optimality score [9]. All newborns underwent a neurological examination according to Prechtl 110).…”

Section: Methodsmentioning

confidence: 99%

Neurological condition in 18-month-old children perinatally exposed to polychlorinated biphenyls and dioxins

Huisman

Koopman-Esseboom

Lanting

et al. 1995

Early Human Development

160

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The neurological optimality of 418 Dutch children was evaluated at the age of 18 months, in order to determine whether prenatal and breast milk mediated exposure to polychlorinated biphenyls (PCBs) and dioxins affected neurological development. Half of the infants were breast-fed. the other half were formula-fed. PCB concentrations in cord and maternal plasma were used as a measure of prenatal exposure to PCBs. To measure postnatal exposure, PCB and dioxin congeners were determined in human milk and in formula milk.After adjusting for covariates, transplacental PCB exposure was negatively related to the neurologkal condition at 18 months. Althc.ugh greater amounts of PCBs and dioxins are transferred via nursing than via placental passage, an effect of lactational exposure to PCBs and dioxins could not be detected. We even found a beneficial effect of breast-feeding on the fluency of movements.We conclude that transplacental PCB passage has a small negative effect on the neurological condition in 18-month-old toddlers.

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Obstetrical condition and neonatal neurological morbidity. An analysis with the help of the optimality concept

Cited by 127 publications

References 4 publications

Relationship Between Umbilical Cord Essential Fatty Acid Content and the Quality of General Movements of Healthy Term Infants at 3 Months

Relationship Between Umbilical Cord Essential Fatty Acid Content and the Quality of General Movements of Healthy Term Infants at 3 Months

Effects of Dioxins and Polychlorinated Biphenyls on Thyroid Hormone Status of Pregnant Women and Their Infants

Neurological condition in 18-month-old children perinatally exposed to polychlorinated biphenyls and dioxins

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