Obstructive nephropathy secondary to sulfasalazine calculi

Russinko, Paul J.; Agarwal, Saurabh; Choi, Michael; Kelty, Patrick

doi:10.1016/s0090-4295(03)00666-6

Cited by 21 publications

(15 citation statements)

References 4 publications

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“…On the other hand, several cases of sulfasalazine-induced renal injury have been reported [2,5,7,36]. Sulfasalazine-induced renal injury might lead to irreversible renal failure, organ transplantation, or even patient death [37][38][39]. There is no precise mechanism(s) for sulfasalazine-induced renal injury.…”

Section: Discussionmentioning

confidence: 99%

Sulfasalazine induces mitochondrial dysfunction and renal injury

et al. 2017

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Sulfasalazine is a commonly used drug for the treatment of rheumatoid arthritis and inflammatory bowel disease. There are several cases of renal injury encompass sulfasalazine administration in humans. The mechanism of sulfasalazine adverse effects toward kidneys is obscure. Oxidative stress and its consequences seem to play a role in the sulfasalazine-induced renal injury. The current investigation was designed to investigate the effect of sulfasalazine on kidney mitochondria. Rats received sulfasalazine (400 and 600 mg/kg/day, oral) for 14 consecutive days. Afterward, kidney mitochondria were isolated and assessed. Sulfasalazine-induced renal injury was biochemically evident by the increase in serum blood urea nitrogen (BUN), gamma-glutamyl transferase (c-GT), and creatinine (Cr). Histopathological presentations of the kidney in sulfasalazine-treated animals revealed by interstitial inflammation, tubular atrophy, and tissue necrosis. Markers of oxidative stress including an increase in reactive oxygen species (ROS) and lipid peroxidation (LPO), a defect in tissue antioxidant capacity, and glutathione (GSH) depletion were also detected in the kidney of sulfasalazine-treated groups. Decreased mitochondrial succinate dehydrogenase activity (SDA), mitochondrial depolarization, mitochondrial GSH depletion, increase in mitochondrial ROS, LPO, and mitochondrial swelling were also evident in sulfasalazine-treated groups. Current data suggested that oxidative stress and mitochondrial injury might be involved in the mechanism of sulfasalazine-induced renal injury. ARTICLE HISTORY

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Section: Discussionmentioning

confidence: 99%

Sulfasalazine induces mitochondrial dysfunction and renal injury

et al. 2017

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“…Both medications and surgery have been used to treat UC [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] . However, surgery is reserved for those with severe inflammation and life-threatening complications.…”

Section: Drug Treatmentmentioning

confidence: 99%

“…The treatment of UC with medications is similar, though not always identical, to the treatment of CD [9][10][11][16][17][18][19][20] . Medications treating UC include anti-inflammatory agents such as 5-ASA compounds, systemic and topical corticosteroids, and immunomodulators.…”

Section: Drug Treatmentmentioning

confidence: 99%

“…Aspirin, however, is not effective in treating UC. On the other hand, 5-ASA is effective in treating UC if the drug can be delivered directly (topically) onto the inflamed colon lining [17][18][19][20][21] . For example, Rowasa for enema is a 5-ASA solution that is effective in treating inflammation in and near the rectum (ulcerative proctitis and ulcerative proctosigmoiditis).…”

Section: -Asa Compounds (Azulfidine Asacol Pentasa Dipentum)mentioning

confidence: 99%

“…Many doctors use 5-ASA compounds at the same time as corticosteroids. In patients who achieve remission with systemic corticosteroids, 5-ASA compounds such as Asacol are often continued to maintain remissions [10,[17][18][19] . In patients whose symptoms return during reduction of the dose of corticosteroids, the dose of corticosteroids is increased slightly to control the symptoms.…”

Section: Proper Use Of Corticosteroidsmentioning

confidence: 99%

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Drug therapy for ulcerative colitis

Meng²,

Pan³

2004

WJG

101

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Ulcerative colitis (UC) is an inflammatory destructive disease of the large intestine occurred usually in the rectum and lower part of the colon as well as the entire colon. Drug therapy is not the only choice for UC treatment and medical management should be as a comprehensive whole. Azulfidine, Asacol, Pentasa, Dipentum, and Rowasa all contain 5-aminosalicylic acid (5-ASA), which is the topical anti-inflammatory ingredient. Pentasa is more commonly used in treating Crohn's ileitis because Pentasa capsules release more 5-ASA into the small intestine than Asacol tablets. Pentasa can also be used for treating mild to moderate UC. Rowasa enemas are safe and effective in treating ulcerative proctitis and proctosigmoiditis. The sulfafree 5-ASA agents (Asacol, Pentasa, Dipentum and Rowasa) have fewer side effects than sulfa-containing Azulfidine. In UC patients with moderate to severe disease and in patients who failed to respond to 5-ASA compounds, systemic (oral) corticosteroids should be used. Systemic corticosteroids (prednisone, prednisolone, cortisone, etc.) are potent and fast-acting drugs for treating UC, Crohn's ileitis and ileocolitis. Systemic corticosteroids are not effective in maintaining remission in patients with UC. Serious side effects can result from prolonged corticosteroid treatment. To minimize side effects, corticosteroids should be gradually reduced as soon as the disease remission is achieved. In patients with corticosteroid-dependent or unresponsive to corticosteroid treatment, surgery or immunomodulator is considered. Immunomodulators used for treating severe UC include azathioprine/6-MP, methotrexate, and cyclosporine. Integrated traditional Chinese and Western medicine is safe and effective in maintaining remission in patients with UC.Xu CT, Meng SY, Pan BR. Drug therapy for ulcerative colitis.

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Conventional Medical Management of Ulcerative Colitis: Sulfasalazine and 5-Aminosalicylates

Khanna

Marshall

2011

Crohn's Disease and Ulcerative Colitis

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Obstructive nephropathy secondary to sulfasalazine calculi

Cited by 21 publications

References 4 publications

Sulfasalazine induces mitochondrial dysfunction and renal injury

Sulfasalazine induces mitochondrial dysfunction and renal injury

Drug therapy for ulcerative colitis

Conventional Medical Management of Ulcerative Colitis: Sulfasalazine and 5-Aminosalicylates

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