2020
DOI: 10.1007/s11886-020-1257-y
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Obstructive Sleep Apnea, Hypertension, and Cardiovascular Risk: Epidemiology, Pathophysiology, and Management

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Cited by 223 publications
(164 citation statements)
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“…The prevalence of OSA is estimated to be 4% in the general population increasing up to 40% in some disease-specific populations, such as in patients suffering from metabolic syndrome [19] , obesity [20] , diabetes mellitus [21] , arterial hypertension [22] , cardiovascular disease [23] , chronic kidney disease [24] and non-alcoholic fatty liver disease [25] . Furthermore, the prevalence of OSA increases with age, race and world region [26] .…”
Section: Obstructive Sleep Apneamentioning
confidence: 99%
“…The prevalence of OSA is estimated to be 4% in the general population increasing up to 40% in some disease-specific populations, such as in patients suffering from metabolic syndrome [19] , obesity [20] , diabetes mellitus [21] , arterial hypertension [22] , cardiovascular disease [23] , chronic kidney disease [24] and non-alcoholic fatty liver disease [25] . Furthermore, the prevalence of OSA increases with age, race and world region [26] .…”
Section: Obstructive Sleep Apneamentioning
confidence: 99%
“…A ativação do sistema nervoso simpático também estimula o SRAA a elevar a produção de aldosterona, assim, haverá maior reabsorção de sódio nos rins e, consequentemente, aumento da pressão arterial. Estudos comprovam que a elevação de aldosterona na síndrome está ligada a hiperprodução de renina e angiotensina II desencadeada pela hiperativação do SNS durante os períodos de hipóxia (LIU et al, 2020;SALMAN;SHULMAN;COHEN, 2020). Entretanto, outros achados recentes com modelos animais sugerem que a hipóxia e hipercapnia influenciam a concentração de aldosterona independentemente da atividade da renina plasmática (CASITAS et al, 2017).…”
Section: Mecanismos Fisiopatológicos Da Hipertensão Arterial Na Saosunclassified
“…OSA and its comorbidities significantly affect patients' quality of life. It is a significant risk factor for hypertension, type II diabetes, stroke, congestive heart failure, coronary artery disease, and premature death [4]. Furthermore, it is associated with poor sleep quality, daytime sleepiness, fatigue, and cognitive dysfunction.…”
Section: Introductionmentioning
confidence: 99%