Obstructive sleep apnoea, gout and cardiovascular risk: A worth studying association

Mirrakhimov, Aibek E.; Mirrakhimov, Erkin M.

doi:10.1016/j.mehy.2013.07.042

Cited by 5 publications

(4 citation statements)

References 10 publications

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“…The inconsistent results between this study and two other studies [ 33 , 36 ] may be related to subject selection, such as differences in age, race, inclusion criteria, and covariate adjustments. In addition, the sample size of patients with long sleep duration was relatively small in this study (n = 19) and in another study examining an elderly Mediterranean population (n = 37) [ 36 ]. Further studies with larger sample sizes are necessary to clarify the relationship between long sleep duration and uric acid levels.…”

Section: Discussioncontrasting

confidence: 86%

Association of sleep quality and sleep duration with serum uric acid levels in adults

Chou

Shen

et al. 2020

PLoS ONE

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Objective To date, the association between sleep duration or sleep quality and hyperuricemia has remained unclear. In addition, sleep duration and quality were not considered concomitantly in previous studies. Thus, this study was aimed toward an examination of the association of sleep duration and quality with uric acid level in a Taiwanese population. Methods A total of 4,555 patients aged ≥18 years were enrolled in this study. The sleep duration was classified into three groups: short (<7 h), normal (7–9 h), and long (≥9 h). The Pittsburgh Sleep Quality Index (PSQI) was used to evaluate sleep quality, and poor sleep quality was defined as a global PSQI score of >5. Results Poor sleepers were younger and had lower body mass index, blood pressure, uric acid, blood sugar, cholesterol, creatinine level, shorter sleep duration, and engaged in less exercise but had a higher white blood cell count and prevalence of smoking as compared to good sleepers. There were also differences in body mass index, blood pressure, uric acid, blood sugar, lipid profiles, and sleep quality among subjects with different sleep durations. After adjusting for other variables, poor sleep quality was associated with lower uric acid levels. In addition, short sleep duration was positively associated with higher uric acid levels. Conclusions Poor sleep quality was related to lower uric acid levels, whereas short sleep duration was associated with higher uric acid levels.

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Section: Discussioncontrasting

confidence: 86%

Association of sleep quality and sleep duration with serum uric acid levels in adults

Chou

Shen

et al. 2020

PLoS ONE

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“…The risk of gout attacks during the night is 2.4 times higher than that during the daytime . Among several explanations that have been put forth for this nocturnal risk, one is the potential role of sleep apnea, which is common among obese men with multiple comorbidities, a typical profile of gout patients . To date, several observational studies have shown that patients with sleep apnea have a high prevalence of hyperuricemia (up to 50%) .…”

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confidence: 99%

Sleep Apnea and the Risk of Incident Gout: A Population‐Based, Body Mass Index–Matched Cohort Study

Peloquin

Dubreuil

Roddy

et al. 2015

Arthritis & Rheumatology

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Objective Sleep apnea is associated with hyperuricemia owing to hypoxia-induced nucleotide turnover. We undertook this study to assess the relationship between incident sleep apnea and the risk of incident gout. Methods Using data from The Health Improvement Network in the UK, we identified individuals with a first-ever physician diagnosis of sleep apnea. For each patient with sleep apnea, up to 5 individuals without sleep apnea were matched by sex, age, birth year, and body mass index (within ±0.5 kg/m2). We estimated the incidence rates of gout and examined the relationship between sleep apnea and the risk of incident gout using a Cox proportional hazards model, adjusting for potential confounders. In addition, we assessed the rate difference in gout due to sleep apnea using an additive hazard model. Results Among 9,865 patients with newly diagnosed sleep apnea and 43,598 matched individuals without sleep apnea, we identified 270 incident cases of gout over 1 year of followup, resulting in incidence rates of 8.4 per 1,000 person-years and 4.8 per 1,000 person-years, respectively. The crude and multivariable rate ratios of incident gout in patients with sleep apnea were 1.7 (95% confidence interval [95% CI] 1.3, 2.2) and 1.5 (95% CI 1.1, 2.1), respectively. The corresponding rate differences between patients with sleep apnea and the comparison cohort were 3.6 (95% CI 1.6, 5.6) and 2.8 (95% CI 0.7, 4.9) per 1,000 person-years. The effect of sleep apnea persisted across subgroups. Conclusion This general population–based study indicates that sleep apnea is independently associated with an increased risk of incident gout. Future research should examine the potential benefits of correcting sleep apnea–induced hypoxia on the risk of hyperuricemia and gout flares.

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“…Cantalejo Moreira et al demonstrated that patients with gout have a trend towards severe sleep disorders compared to patients with osteoarthritis [62]. Another finding in the study performed by Cantalejo Moreira et al was that there is a greater burden of cardiovascular risk factors among patients with gout [63]. Circulating UA levels in women are clearly lower than those in men, which is putatively the result of the sex hormone in action [64].…”

Section: Discussionmentioning

confidence: 99%

Big Data Analysis of the Relationship between Sleep Duration, Hyperuricemia, and Hypertension

戴秀珍¹,

Tai²,

Huang³

et al. 2022

Journal of Internet Technology

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<p>Previous studies have reported that sleep duration may increase the risk of hypertension and hyperuricemia. However, the results are contradictory. We investigated whether sleep duration was independently associated with hypertension and hyperuricemia. We aimed to assess the association between sleep duration, hypertension, and hyperuricemia in a population-based cross-sectional study. MJ Health Examination Center Database was used to obtain a large, representative sample of Taiwan population. This study revealed that short sleep duration is associated with an increased risk of hyperuricemia and hypertension. Patients who sleep ≤ 4 hours have a higher risk of hypertension than those who sleep 7 hours (Male: AOR = 1.131, 95% CI = 1.073-1.192; Female: AOR = 1.257, 95% CI = 1.190 -1.327). The risk of hyperuricemia in patients who sleep ≤ 4 hours is higher than those who sleep 7 hours (Male: AOR = 1.657, 95% CI = 1.213-5.768; Female: AOR = 1.583, 95% CI = 1.050-3.660). Besides, the risk of hyperuricemia in females who slept for more than 8 hours was 1.019 times that of those who slept for 7 hours. Participants aged < 50 years who sleep less than 4 hours a day have a higher risk of hypertension and hyperuricemia than those of the ages of 50-75 and >75 years. There were excellent response rates to sleep duration associated with hypertension and hyperuricemia questions and measurements representative sample of Taiwan population.</p> <p> </p>

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Obstructive sleep apnoea, gout and cardiovascular risk: A worth studying association

Cited by 5 publications

References 10 publications

Association of sleep quality and sleep duration with serum uric acid levels in adults

Association of sleep quality and sleep duration with serum uric acid levels in adults

Sleep Apnea and the Risk of Incident Gout: A Population‐Based, Body Mass Index–Matched Cohort Study

Big Data Analysis of the Relationship between Sleep Duration, Hyperuricemia, and Hypertension

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