Obstructive sleep apnoea is associated with myocardial injury in patients with refractory angina

Geovanini, Glaucylara Reis; Pereira, Alexandre C.; Gowdak, Luís Henrique Wolff; Dourado, Luciana Oliveira Cascaes; Poppi, Nilson Tavares; Venturini, Gabriela; Drager, Luciano F.; Lorenzi-Filho, Geraldo

doi:10.1136/heartjnl-2015-309009

Cited by 7 publications

(10 citation statements)

References 31 publications

(30 reference statements)

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“…(Figure 1 here) After evaluating the 6 observational articles included in the present study, it was clear that 5 articles were cross-sectional (Geovanini et al, 2016;Kohno et al, 2017;Randby et al, 2012;Roca et al, 2015;Roca et al, 2013), and the other research work was performed using the cohort method (Shah et al, 2013). The final collected studies were published between 2012 and 2018.…”

Section: Resultsmentioning

confidence: 94%

“…The final collected studies were published between 2012 and 2018. Three of these works were conducted in the United States (Roca et al, 2015;Roca et al, 2013;Shah et al, 2013) and the other studies had taken place in Japan (Kohno et al, 2017), Brazil (Geovanini et al, 2016) and Norway (Randby et al, 2012). The samples in 2 studies were hospitalized patients (Kohno et al, 2017;Shah et al, 2013).…”

Section: Resultsmentioning

confidence: 99%

“…The samples in 2 studies were hospitalized patients (Kohno et al, 2017;Shah et al, 2013). One study examined patients referred to a heart clinic (Geovanini et al, 2016) and another work selected the sample from a sleep laboratory (Randby et al, 2012). The remaining two studies selected their sample from the study population in the ARIC cohort conducted in the United States between 1987-1989 (Roca et al, 2015;Roca et al, 2013).…”

Section: Resultsmentioning

confidence: 99%

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Associations between obstructive sleep apnea and cardiac troponin T levels: a meta-analysis

et al. 2022

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Objective: Cardiac troponin T (cTnT) is a sensitive indicator for heart damage and is an important clinical marker for acute myocardial infarction (MI). The recent development of a high-sensitivity cardiac troponin T (hs-cTnT) assay allows a more accurate diagnosis of C concentration. There appears to be an association between OSA and changes in serum cTnT levels. However, current research works in this area have reported mixed results. Therefore, this meta-analysis study was performed to evaluate the relationship between cTnT levels and OSA. Method:The Scopus, Embase, Web of Science, PubMed and Science Direct databases were searched without a lower time limit and until April 2020. In order to perform the meta-analysis, the heterogeneity of articles was examined using the I 2 test, and subsequently a random effects model was applied. Data analysis was performed using the Comprehensive Meta-Analysis software (version 2).Result: Six studies involving a total of 1,689 cases and 2,171 controls were included in this meta-analysis. The results of our study suggest that the aggregate odds ratio of hs-cTnT level in patients with OSA is 1.25 (95% confidence interval: 0.97-1.61). Conclusion:Our findings indicate that patients with OSA have 25% higher rate of hs-cTnT levels than people without OSA.

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Section: Resultsmentioning

confidence: 94%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Associations between obstructive sleep apnea and cardiac troponin T levels: a meta-analysis

et al. 2022

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“…Several studies found higher troponin concentrations independently associated with AHI in untreated OSA patients free of CAD. 5,12,25 Geovanini et al 26 showed that OSA severity was independently associated with hs-TropT levels in patients with refractory angina. In contrast, no significant difference in troponin levels between moderate/severe and mild/no OSA was reported by Maeder et al 27 In this study, short-term CPAP also had no impact on troponin concentrations before and after sleep.…”

Section: Discussionmentioning

confidence: 99%

Natriuretic Peptide and High-Sensitive Troponin T Concentrations Correlate with Effectiveness of Short-Term CPAP in Patients with Obstructive Sleep Apnea and Coronary Artery Disease

Strehmel

Valo

Teupe

2016

Clin Med Insights Circ Respir Pulm Med

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The risk of cardiovascular complications is increased in patients with obstructive sleep apnea (OSA). Continuous positive airway pressure (CPAP) is the most effective way to treat clinically significant OSA. We hypothesized that the concentrations of the cardiac risk markers N-terminal brain natriuretic peptide (NT-proBNP) and high-sensitive troponin T (hs-TropT) correlate with the effectiveness of CPAP therapy in patients with OSA and coexisting coronary artery disease (CAD). Twenty-one patients with severe OSA and coexisting CAD (group 1) and 20 control patients with severe OSA alone (group 2) were treated with CPAP and monitored by laboratory-based polysomnography. NT-proBNP and hs-TropT levels were measured before and after CPAP. Apnea–hypopnea index (AHI) and oxygen desaturation were similar in both groups. In group 1, hs-TropT levels correlated with AHI and oxygen desaturation upon CPAP. Elevated NT-proBNP levels in group 1 were significantly reduced by CPAP. NT-proBNP levels correlated with AHI and showed negative correlation with ST-segment depression. No such correlations were found in group 2. CPAP has the potential to normalize elevated NT-proBNP serum levels in patients with severe OSA and coexisting CAD. Levels of NT-proBNP and hs-TropT correlated with AHI and oxygen desaturation.

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“…It is associated with somnolence and fatigue as mentioned, impaired cognitive function, deficit in sustained attention which may result in an increased motor vehicle accident risk [ 5 , 6 ] and is also a source of lost productivity in the workplace [ 7 ]. The Sleep Heart Health and other studies [ 8 ] have suggested that patients with OSA are at increased risk of cardiovascular disease, including hypertension [ 9 ], myocardial infarction, refractory angina [ 10 ], stroke [ 11 ] and even death. In addition, nocturnal cardiac arrhythmias [ 12 , 13 ] and mild-to-moderate pulmonary hypertension can be present in patients with OSA [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Should the diagnosis and management of OSA move into general practice?

Suárez

Osorio

Torres

et al. 2016

Breathe

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Obstructive sleep apnoea (OSA) together with insomnia are the most common sleep disorders [1]. OSA is secondary to complete or partial airway obstruction caused by recurrent pharyngeal collapse during sleep [2], producing loud snoring or choking and frequent awakenings. This chronic sleep disturbance results in daytime sleepiness and fatigue that impedes patient’s ability to function, thereby negatively affecting his or her quality of life [3, 4]. In 2015, the American Academy of Sleep Medicine (AASM) task force released quality measures for the care of adult patients with OSA. The first quality measure outcome is to improve detection and categorisation of OSA symptoms and severity [4].

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Obstructive sleep apnoea is associated with myocardial injury in patients with refractory angina

Abstract: Very severe OSA is common and independently associated with overnight myocardial injury in patients with refractory angina.

Cited by 7 publications

References 31 publications

Associations between obstructive sleep apnea and cardiac troponin T levels: a meta-analysis

Associations between obstructive sleep apnea and cardiac troponin T levels: a meta-analysis

Natriuretic Peptide and High-Sensitive Troponin T Concentrations Correlate with Effectiveness of Short-Term CPAP in Patients with Obstructive Sleep Apnea and Coronary Artery Disease

Should the diagnosis and management of OSA move into general practice?

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