Obtaining and Determining Antiviral and Antibacterial Activity of S-Esters of 4-R-Aminobenzenethiosulfonic Acid

Abstract

A number of S-esters of 4-R-aminobenzene¬thiosulfonic acids were synthesized via alkylation of the sodium salt of 4-acetylaminobenzenethiosulfonic acid with various alkylating agents and acylation of the corresponding esters of 4-aminobenzenethiosulfonic acid with metha-cryloyl chloride. For obtaining S-methyl 4-(acetyla-mino)benzenesulfonothioate, it was developed a synthetic technique corresponding to the basic principles of "green chemistry". The degree of compound cytotox-icity was measured by determining A-549 cell growth using colorimetric method. The antibacterial activity of the thiosulfonates was determined by the agar diffusion test and the antiviral action by their cytopathic effect at TCID50 value.