Obtaining Hydrogels based on PVP/PVAL/Chitosan Containing Pseudoboehmite Nanoparticles for Application in Drugs

Abstract

People with skin lesions caused by burns, ulcerations and other complications, independent of degree and extension of the problem, has induced the search for methods and materials to optimize the process of tissue repair in matter of time and quality. Thus, materials made by synthetic polymers have been used and improved due to overwhelming demand. The efficacy of dressings and bandage depends on a variety of factors such as biocompatibility, composition uniformity, low cost, long validity, flexibility, and so on. In this chapter, hydrophilic membranes based on polyvinylpyrrolidone-PVP/poly(vinyl alcohol)-PVAl and chitosan containing nanoparticles of pseudoboehmite for use in pharmaceuticals were developed and studied. The hydrogels were obtained by ionizing radiation in electronbeam accelerator at a dose of 25 kGy and characterized by mechanical, thermal and physicochemical tests. Pseudoboehmite nanoparticles were obtained from aluminum nitrate by a sol-gel process. The characterization of the hydrogels was done by various tests such as tensile, swelling, thermal analysis, sol-gel fraction and dynamic mechanical analysis. The results show that the presence of PVAl hydrophilic membrane causes lower degree of swelling, greater attraction and greater resistance to elongation at break in tension, although significantly lower fraction of gel membranes contains only agar and PVP. It was verified that the presence of chitosan nanoparticles and pseudoboehmite promotes a decrease in the formation of cross-links during irradiation of hydrophilic membranes.

Synthesis of Pseudoboehmite - Aging Effect

“…Other research was realized with hydrophilic membranes based on polyvinylpyrrolidone-PVP/poly(vinyl alcohol)-PVA and chitosan containing nanoparticles of pseudoboehmite for use in pharmaceuticals. It was verified that the presence of chitosan nanoparticles and pseudoboehmite promotes a decrease in the formation of cross-links during irradiation of hydrophilic membranes [4]. The synthesis of an additive-free hydrothermal synthesis method to prepare high quality boehmite was reported by Zhang et alii [5].…”

Controle De Óbitos Decorrentes Na Pandemia Covid19 Nas Unidades De Um Hospital De Referência No Estado Da Paraíba

“…Os hidrogéis a base de PVP, tendo como precursores poli (n-vinil-2-pirrolidona) (PVP), ágar e agentes plastificantes como o polietilenoglicol conferem uma forma física antes da reticulação, tornando viável o processo de irradiação (MIRANDA et al, 2018).…”