The Ministry of Social Affairs of the Republic of Indonesia has a very heavy responsibility in ensuring that the Child Welfare Institution (LKSA) can carry out the mandate of the Law in implementing the process of caring for neglected children. This paper aims to evaluate the impact and analyze the influence of transformational leadership against organizational performance, mediated by organizational learning, organizational commitment, and organizational culture, altruism as the moderator. This study was conducted using the Partial Least Square method in analyzing the behavior of the highest Leadership of the Child Welfare Institution (LKSA) of the Ministry of Social Affairs of the Republic of Indonesia, with a sample of 185 A-accredited institutions throughout Indonesia. The results of the study indicate that several factors affect the process of evaluating organizational performance. First, LKSAs need to improve the quality of their organizational performance in accordance with the requirements of the Ministry of Social Affairs consistently and sustainably in carrying out the fulfillment of service quality standards. The contribution of novelty in this study is that the variable organizational commitment cannot improve organizational performance. This means that the consistency of the implementation of organizational commitment has no effect when the highest leadership cannot carry out the sustainability of the standards that have been prepared with difficulty. But on the other hand, transformational leadership can maximize organizational performance.