“…Cldn-1, Ocln, ZO-1), have been shown to respond to changes in environmental conditions (Castillo et al, 1991;Chasiotis and Kelly, 2009;Tokuda et al, 2010). Over 30 genes encoding amphibian TJ proteins have now been reported, yet little is known about their contribution to TJ permeability (Cardellini et al, 1996;Cordenonsi et al, 1997;Fesenko et al, 2000;Klein et al, 2002;Chasiotis and Kelly, 2009;Chang et al, 2010;Saharinen et al, 2010;Yamagishi et al, 2010;Baltzegar et al, 2013;Sun et al, 2015). In addition, the majority of these genes have been identified in the strictly aquatic anurans Xenopus laevis and Xenopus tropicalis; thus, almost nothing is known about the characteristics of TJ proteins in terrestrial and semi-aquatic amphibians (Günzel and Yu, 2013).…”