The static and dynamic load-bearing capacities and failure modes of zirconia crowns screwed to multi-unit abutments (MUAs) with and without a titanium base (T-base) were determined. Thirty-six monolithic zirconia crowns screwed to straight MUAs torqued to laboratory analogs (30 Ncm) were assigned to two groups (n = 18). In group A, the zirconia crowns were screwed directly to the MUAs; in group B, the zirconia crowns were cemented to the T-base and screwed to the MUAs. All specimens were aged in 100% humidity (37 °C) for one month and subjected to thermocycling (20,000 cycles). Afterwards, the specimens underwent static and dynamic loading tests following ISO 14801. The failure modes were evaluated by stereomicroscopy (20×). There was an unequivocally similar trend in the S-N plots of both specimen groups. The load at which the specimens survived 5,000,000 cycles was 250 N for both groups. Group A failed mainly within the metal, and zirconia failure occurred only at a high loading force. Group B exhibited failure within the metal mostly in conjunction with adhesive failure between the zirconia and T-base. Zirconia restoration screwed directly to an MUA is a viable option, but further studies with larger sample sizes are warranted.