Occult hepatitis B in Egyptian thalassemic children

Shaker, Olfat; Ahmed, Abeer; Satar, Inas Abdel; Ahl, Hamza El; Shousha, Wafaa Gh.; Doss, Wahid

doi:10.3855/jidc.1706

Cited by 25 publications

(23 citation statements)

References 16 publications

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“…In contrast to our study, Shaker and coworkers evaluated 80 Egyptian thalassemia patients and found an OBI prevalence of 32.5% (26 patients). Twenty cases of their whole study group were also positive for both HCV RNA and HBV DNA (33). Similar to our results, Arababad et al found that none of 60 evaluated thalassemic patients had OBI.…”

Section: Occult Hepatitis B Infection and Thalassemiasupporting

confidence: 91%

Occult Hepatitis B Infection in Hepatitis C Patients with Hematological Disorders

Jonaidi-Jafari

Rezaee‐Zavareh

Tavallaei-Nosratabadi

et al. 2016

Jundishapur J Microbiol

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Section: Occult Hepatitis B Infection and Thalassemiasupporting

confidence: 91%

Occult Hepatitis B Infection in Hepatitis C Patients with Hematological Disorders

Jonaidi-Jafari

Rezaee‐Zavareh

Tavallaei-Nosratabadi

et al. 2016

Jundishapur J Microbiol

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“…In conclusion, the findings that indicated HBS antigen and HIV antibody were negative in patients with thalassemia in Kermanshah province and also the low frequency of infection in hepatitis C in these patients are strengths of this study, while it still seems necessary to evaluate the possibility of Occult Hepatitis B infection (OBI) with molecular methods (24,25). The latter issue could be further studied through a prospective study.…”

Section: Discussionmentioning

confidence: 81%

Hepatitis B, Hepatitis C, and Human Immunodeficiency Virus Infection in Multi-Transfused Thalassemic Patients, Kermanshah, Iran, 2015

Sayad

Foroughikia

Akramipour

et al. 2017

Jundishapur J Microbiol

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Background: Repeated blood transfusions in Thalassemic patients predispose them to blood-borne infections including Hepatitis B, Hepatitis C, and human immunodeficiency virus. These infections cause cirrhosis, portal hypertension, and acquired immunodeficiency syndrome. Objectives: The current study aimed at determining the prevalence of these infections in Thalassemic patients of Kermanshah province, Iran. Methods: Thalassemic patients registered at Mohammad Kermanshahi university hospital were included. Demographic data, history of blood transfusions, Hepatitis B surface antigen (HBsAg), Hepatitis B core antibody (HBC Ab), Hepatitis B surface antibody (HBs Ab), Hepatitis C antibody, and Human immunodeficiency virus (HIV) antibody were extracted. Serologic tests were done using the third-generation enzyme linked immunosorbent assay (ELISA) and positive Hepatitis C virus (HCV) Ab and HIV Ab results was confirmed by Western Blotting. Results: A total number of 232 patients were enrolled (111 females and 121 males), among whom HBsAg and HIV Ab were both negative. Positive HBS Ab was reported in 222 subjects (95.7%) and 19 cases (8.2%) had positive HBC Ab. Immunity to hepatitis B was the result of vaccination in 87.5% of cases. Hepatitis C antibody was positive in 14 cases (6%). Finally, a significant relationship was found between HCV infection and blood transfusion done before 1996. Conclusions: High rate of hepatitis C was found to be due to the lack of screening for HCV Ab among blood donors before 1996. The negative HBS Ag can be justified by regular hepatitis B vaccination program in patients with thalassemia. The lack of HIV infection was concluded to be attributed to the low prevalence of this virus in the general population and blood donors as well as proper screening methods.

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“…Studies in Egypt and India, for instance, found 32.5-32.8% occult HBV infections in children with thalassemia. 17,18 Moreover, Shaker et al found OHB in all HCV-infected subjects. 17 Occult hepatitis B is defined as the detection of HBV DNA in patients with serial negative results for HbsAg, with or without hepatitis B antibodies.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of hepatitis and its correlation with serum ferritin and aminotransferase levels among thalassemia major patients in Indonesia

Wahidiyat

Liauw

Adnani

et al. 2017

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Background Thalassemia major patients who undergo routine transfusion have an increased risk of acquiring transfusiontransmitted infections (TTI), including hepatitis B and C. These diseases have serious implications and may affect the serum ferritin and aminotransferase levels of thalassemia major patients. Objectives To identify the prevalence of hepatitis B and/or C infections among thalassemia major patients and to evaluate its correlation with serum ferritin and aminotransferase levels. Methods This was across-sectional study conducted at the Thalassemia Center of Dr. Cipto Mangunkusumo Hospital in Jakarta, Indonesia. The subjects were screened for hepatitis B and C infections, and their serum ferritin and aminotransferase levels were also measured. Results In total, 621 subjects were included in the study, among which 5 subjects tested positive for hepatitis B surface antigen (HBsAg) (0.8%), 111 subjects tested positive for anti-HCV (17.8%), and 5 subjects tested positive for both HBsAg and anti-HCV (0.8%). The subjects who tested positive for hepatitis B, hepatitis C, or both showed significantly higher values of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and serum ferritin compared to their negative counterparts. Moreover, serum ferritin showed a positive, moderate correlation with both AST and ALT. Conclusion This study shows a significant association between hepatitis and serum ferritin as well as aminotransferase levels. Early detection and early management of hepatitis B and C infections is warranted to minimize the occurrence of liver damage in thalassemia major patients.

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Occult hepatitis B in Egyptian thalassemic children

Cited by 25 publications

References 16 publications

Occult Hepatitis B Infection in Hepatitis C Patients with Hematological Disorders

Occult Hepatitis B Infection in Hepatitis C Patients with Hematological Disorders

Hepatitis B, Hepatitis C, and Human Immunodeficiency Virus Infection in Multi-Transfused Thalassemic Patients, Kermanshah, Iran, 2015

Prevalence of hepatitis and its correlation with serum ferritin and aminotransferase levels among thalassemia major patients in Indonesia

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