Occult hepatitis B infection in Portuguese patients with chronic hepatitis C liver disease

Cardoso, Cláudia; Alves, Ana Luísa; Augusto, F.; Freire, Ricardo; Quintana, Carlos; Gonçalves, Matilde; Oliveira, Ana Patrícia de

doi:10.1097/meg.0b013e328359fe54

Cited by 16 publications

(44 citation statements)

References 34 publications

(72 reference statements)

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“…In general, HCV coinfection has been considered as one of the main reasons for inducing OBI [31], and prevalences of occult HBV infection have been reported to be significantly higher in HCV chronically coinfected patients as compared to HCV-negative individuals [32, 33]. …”

Section: Discussionmentioning

confidence: 99%

Prevalence of Occult Hepatitis B Virus Infection in a Cohort of HIV-Positive Patients Resident in Sicily, Italy

Tramuto

Maida

Colomba

et al. 2013

BioMed Research International

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Occult hepatitis B virus (OBI) in HIV-infected groups is still debated, as well as the associated risk-factors and clinical significance. In this paper, we examined a total of 405 HBsAg-negative/HIV-infected patients enrolled from January 2007 to December 2009. Overall, the prevalence of OBI was 5.9% (95% confidence interval (CI95%): 3.8–8.7%); it was more frequently associated with “anti-HBc alone” serological marker (11.3%; adjusted odds ratio = 3.7, CI95%: 1.4–9.8), although it was also detected in the absence of any HBV serological marker (4.9%; CI95%: 2.3–9.1%). A low prevalence of anti-HCV-positive patients with OBI was found (3.1%; CI95%: 0.6–8.7%). HIV RNA plasma levels or other immunological/clinical characteristics were not significantly associated with OBI. All but one occult HBV infections were sustained by genotype D viral strains. OBI is relatively frequent in HIV-infected patients, although it does not seem to exert a relevant clinical impact. Viral genotypes in occult HBV infections reflect those circulating in the Mediterranean area.

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Section: Discussionmentioning

confidence: 99%

Prevalence of Occult Hepatitis B Virus Infection in a Cohort of HIV-Positive Patients Resident in Sicily, Italy

Tramuto

Maida

Colomba

et al. 2013

BioMed Research International

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“…The main characteristics of the 34 studies included in the meta-analysis are summarized in Tables 1 and 2; 6 26,29,42,45,51,53 evaluated the prevalence of OBI in subjects without chronic liver disease, 30 5,7,[22][23][24][25][26][27][28][30][31][32][33][34][35][36][37][38][39][40][41][43][44][45][46][47][48][49][50]52 in those with chronic liver disease and 2 26,45 in both. All were cross-sectional studies, but 3 7,46,50 were cohort studies.…”

Section: Study Characteristicsmentioning

confidence: 99%

An estimation of the prevalence of occult HBV infection in Western Europe and in Northern America: A meta‐analysis

Pisaturo

Onorato

Russo

et al. 2019

Journal of Viral Hepatitis

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Data on the prevalence of occult HBV infection (OBI) in Western Europe and in Northern America are few; hence, we conducted a systematic review and meta‐analysis. All studies included had to fulfil the following inclusion criteria: (a) they investigated the prevalence of OBI (HBV DNA in liver tissue in HBsAg‐negative subjects), (b) were carried out in Western Europe and in Northern America; (c) were available as a full‐text manuscript, (d) written in English and (e) published up to December 2018. The exclusion criteria were as follows: (a) meta‐analyses, letters, reviews, meeting abstracts or editorial comments; (b) studies investigating HBsAg‐positive patients; (c) those investigating OBI outside Western Europe and in Northern America; and (d) to avoid small sample bias in the random‐effects model, those enrolling less than five subjects. Thirty‐four studies met the inclusion criteria, allowing a meta‐analysis on 2729 patients. The overall prevalence of OBI was 34% (95% CI = 26%‐42%), 28% (CI 95%: 12%‐48%) in 329 subjects without chronic liver disease and 35% (95% CI 26%‐44%) in 2400 patients with chronic liver disease. The prevalence of OBI was 51% (95% CI 40%‐62%) in the 823 anti‐HBc‐positive subjects and 19% (95% CI 10%‐30%) in the 1,041 anti‐HBc‐negative subjects. Evaluating the data from 17 studies comparing anti‐HBc‐positive and negative subjects, the prevalence of OBI was higher in the 641 anti‐HBc‐positive subjects than in the 1041 anti‐HBc‐negative (prevalence ratio = 2.29; 95% CI = 1.61‐3.26, P < .001). This meta‐analysis showed that in HBsAg‐negative subjects the prevalence of OBI was high and was associated with anti‐HBc positivity.

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“…The prevalence of OBI detected in liver tissue was reported as 38.8% in 326 Italian patients with chronic HCV infection[18], 57% in 100 Portuguese patients[19], and 15.0% in 167 Japanese patients as determined by nested PCR[13], and 50% in 44 patients with HCV-related advanced cirrhosis in the United States as determined by real-time PCR[20]. …”

Section: Discussionmentioning

confidence: 99%

“…The OBI prevalence in chronic HCV patients was 45.7% (42/92) in Morocco[25] and 20% (18/50) in Iran[26], while none of 100 Portuguese patients showed serum OBI[19]. A retrospective study in Taiwan showed that serum OBI prevalence as determined by nested PCR using 3 sets of primers in patients with chronic HCV infection was 14.8% (31 of 210), which did not differ from that of healthy controls (15%, 15/100), and the prevalence of OBI did not parallel the severity of liver disease (14.5% in chronic hepatitis, 8% in liver cirrhosis, and 22% in HCC)[27].…”

Section: Discussionmentioning

confidence: 99%

“…Our method followed the Taormina Expert Meeting Statements [17], in which the presence of OBI was defined as proved positivity in 2 or more different viral genomic regions by nested PCR and included adequate positive and negative controls. Previous data suggested that the prevalences of OBI detected in liver tissue were higher than those in blood, though reports of head-to-head comparisons of both methodologies are limited[19,28]. Integration of the HBV genome into the host genome is a plausible explanation.…”

Section: Discussionmentioning

confidence: 99%

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Occult hepatitis B virus infection is not associated with disease progression of chronic hepatitis C virus infection

Jun-Hyeon¹,

Lee²,

Choi³

et al. 2016

WJG

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AIMTo clarify the prevalence of occult hepatitis B virus (HBV) infection (OBI) and the association between OBI and liver disease progression, defined as development of liver cirrhosis or hepatocellular carcinoma (HCC), worsening of Child-Pugh class, or mortality in cases of chronic hepatitis C virus (HCV) infection.METHODSThis prospective cohort study enrolled 174 patients with chronic HCV infection (chronic hepatitis, n = 83; cirrhosis, n = 47; HCC, n = 44), and evaluated disease progression during a mean follow-up of 38.7 mo. OBI was defined as HBV DNA positivity in 2 or more different viral genomic regions by nested polymerase chain reaction using 4 sets of primers in the S, C, P and X open reading frame of the HBV genome.RESULTSThe overall OBI prevalence in chronic HCV patients at enrollment was 18.4%, with 16.9%, 25.5% and 13.6% in the chronic hepatitis C, liver cirrhosis and HCC groups, respectively (P = 0.845). During follow-up, 52 patients showed disease progression, which was independently associated with aspartate aminotransferase > 40 IU/L, Child-Pugh score and sustained virologic response (SVR), but not with OBI positivity. In 136 patients who were not in the SVR state during the study period, OBI positivity was associated with neither disease progression, nor HCC development.CONCLUSIONThe prevalence of OBI in chronic HCV patients was 18.4%, and OBI was not associated with disease progression in South Koreans.

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Occult hepatitis B infection in Portuguese patients with chronic hepatitis C liver disease

Abstract: Occult HBV infection occurred in a high percentage of patients but was not clinically significant.

Cited by 16 publications

References 34 publications

Prevalence of Occult Hepatitis B Virus Infection in a Cohort of HIV-Positive Patients Resident in Sicily, Italy

Prevalence of Occult Hepatitis B Virus Infection in a Cohort of HIV-Positive Patients Resident in Sicily, Italy

An estimation of the prevalence of occult HBV infection in Western Europe and in Northern America: A meta‐analysis

Occult hepatitis B virus infection is not associated with disease progression of chronic hepatitis C virus infection

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