Occult pulmonary haemorrhage in leukaemia.

Golde, David W.; Drew, W. Lawrence; Klein, Harold P.; Finley, Theodore N.; Cline, Martin J.

doi:10.1136/bmj.2.5964.166

Cited by 144 publications

(104 citation statements)

References 10 publications

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“…Perls' Prussian blue staining highlighted a large number of iron-laden macrophages (60%; fig. 3a) with a Golde score of 120 [6]. No pathogen was identified in either the BAL or the sputum.…”

Section: Case Reportmentioning

confidence: 99%

Diffuse interstitial pneumonia and pulmonary hypertension: a novel manifestation of chronic granulomatous disease

Khaldi

Marchand-Adam²,

Kannengiesser³

et al. 2009

Eur Respir J

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The present authors report the case of an adult with chronic granulomatous disease who developed an unusual lung fibrosis associated with severe pulmonary hypertension.Histological analysis of a lung biopsy showed a diffuse infiltration with pigmented macrophages without granulomas, which particularly involved the pulmonary arterial and venular walls. Clinical and histological findings were suggestive of pulmonary veno-occlusive disease.Such a clinical association has not been previously described in the literature and might be due to the persistent expression of gp91phox at a very low level.In conclusion, the present case report illustrates a novel manifestation of chronic granulomatous disease.

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Section: Case Reportmentioning

confidence: 99%

Diffuse interstitial pneumonia and pulmonary hypertension: a novel manifestation of chronic granulomatous disease

Khaldi

Marchand-Adam²,

Kannengiesser³

et al. 2009

Eur Respir J

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“…thrombocytopenic or unstable patients. Several criteria based on BAL data have been proposed for diagnosing alveolar haemorrhage [8][9][10][11][12]. Perhaps the most commonly employed BAL criterion is the presence of o20% haemosiderinladen macrophages in BAL fluid (BALF) [12].…”

mentioning

confidence: 99%

Haemosiderin-laden macrophages in the bronchoalveolar lavage fluid of patients with diffuse alveolar damage

Maldonado

Parambil

Yi³

et al. 2009

Eur Respir J

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Quantification of haemosiderin-laden macrophages in bronchoalveolar lavage fluid (BALF) has been used to diagnose diffuse alveolar haemorrhage (DAH) but has not been assessed in patients with diffuse alveolar damage (DAD).The present study analysed BALF obtained from 21 patients with DAD diagnosed by surgical lung biopsy.The median age of 21 patients with DAD was 68 yrs (range 18-79 yrs); 14 (67%) were male and 12 (57%) were immunocompromised. The median proportion of haemosiderin-laden macrophages in BALF was 5% (range 0-90%), but was o20% in seven (33%) patients, fulfilling the commonly used BALF criterion for DAH. There was a trend toward a positive correlation between the percentage of haemosiderin-laden macrophages in BALF and parenchymal haemorrhage assessed semiquantitatively by histopathological analysis. Patients with o20% haemosiderinladen macrophages in BALF showed a significantly increased mortality rate (p50.047) compared to those with ,20%.In patients with an acute onset of diffuse lung infiltrates and respiratory distress, o20% haemosiderin-laden macrophages in BALF can occur with DAD, and is not necessarily diagnostic of DAH. The finding of o20% haemosiderin-laden macrophages in BALF is associated with a worse prognosis in patients with DAD.

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“…BALF cytology included differential cell counts and investigation for possible specific diagnoses, such as alveolar hemorrhage, primary or metastatic pulmonary malignancy, common or specific lung infections (eg, caused by Pneumocystis jirovecii, cytomegalovirus, or mycobacteria), or pulmonary manifestations of a systemic disease (eg, sarcoidosis, collagen vascular disease). In subjects with a clinical suspicion of diffuse alveolar hemorrhage and increased number of hemosiderin-laden macrophages in BALF, the Golde score was calculated, as originally defined by Golde et al 12 A Golde score of Ͼ100 was considered to indicate severe diffuse alveolar hemorrhage, whereas a score between 20 and 100 was considered mild to moderate. In addition, direct or indirect signs of malignancy from direct inspection of the bronchial tree, macroscopic appearance of distal secretions surging from segmental bronchial inlets (serous, mucous, purulent, and/or bloody), bronchial mucosal edema, or friability were recorded as well.…”

Section: Bronchoscopymentioning

confidence: 99%

The Role of Bronchoscopic Findings and Bronchoalveolar Lavage Fluid Cytology in Early Diagnosis of Ventilator-Associated Pneumonia

et al. 2016

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Occult pulmonary haemorrhage in leukaemia.

Cited by 144 publications

References 10 publications

Diffuse interstitial pneumonia and pulmonary hypertension: a novel manifestation of chronic granulomatous disease

Diffuse interstitial pneumonia and pulmonary hypertension: a novel manifestation of chronic granulomatous disease

Haemosiderin-laden macrophages in the bronchoalveolar lavage fluid of patients with diffuse alveolar damage

The Role of Bronchoscopic Findings and Bronchoalveolar Lavage Fluid Cytology in Early Diagnosis of Ventilator-Associated Pneumonia

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