Occult recurrence of monomorphic epitheliotropic intestinal T‐cell lymphoma and the role of MATK gene expression in diagnosis

Chen, Yunxin; Tan, Soo‐Yong; Petersson, Bengt Fredrik; Khor, Yiu Ming; Gopalakrishnan, Sathish; Tan, Daryl

doi:10.1002/hon.2288

Cited by 15 publications

(10 citation statements)

References 10 publications

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“…TCR comprises an αβ or γδ heterodimer, and αβ is a major component in PTCL as well as T‐lymphocytes . PTCL subtypes derived from γδ T cells—such as primary cutaneous γδ T‐cell lymphoma, hepatosplenic T‐cell lymphoma, and monomorphic intestinal T‐cell lymphoma—show aggressive clinical behavior . We recently documented that nodal EBV‐positive CTL has poor prognosis often with a γδ phenotype .…”

Section: Introductionmentioning

confidence: 99%

“…16,17 PTCL subtypes derived from cd T cells-such as primary cutaneous cd T-cell lymphoma, hepatosplenic T-cell lymphoma, and monomorphic intestinal T-cell lymphoma-show aggressive clinical behavior. 1,2,[18][19][20][21][22] We recently documented that nodal EBV-positive CTL has poor prognosis often with a cd phenotype. 7,8,23 On the other hand, recent studies shed a light on an indolent cytotoxic T-cell lymphoma/LPD, characterized by a TCRab phenotype and younger onset age, referred to as subcutaneous panniculitis-like T-cell lymphoma with an ab T-cell phenotype.…”

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confidence: 99%

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Reappraisal of nodal Epstein‐Barr Virus‐negative cytotoxic T‐cell lymphoma: Identification of indolent CD5⁺ diseases

et al. 2018

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Nodal cytotoxic molecule (CM)‐positive peripheral T‐cell lymphoma (CTL) has recently been recognized as a clinicopathologically distinct disease. To further characterize this disease, here we compared 58 patients with Epstein‐Barr virus (EBV)‐negative CTL to 48 patients with EBV‐positive CTL. The two groups did not differ in histopathology, T‐cell receptor (TCR) expression or rearrangement incidences, or survival curves. However, patients with EBV‐negative CTL less frequently showed hepatic involvement (P = .007), B symptoms (P = .020), hemophagocytosis (P = .024), and detectable CD4 (P = .002) and CD5 (P = .009). Univariate and multivariate analyses identified three factors that independently predicted favorable survival, onset age <60 years (P = .002), CD5 expression (P = .002), and mixed morphology (P = .013), TCRαβ was not an independent predictor (P = .30), but was strongly linked with long survivorship among patients younger than 60 years old. A prognostic model incorporating these factors worked well for prognostic delineation, independently of the International Prognostic Index (P = .007 vs P = .082) and Prognostic Index for PTCL (P = .020 vs P = .15). Moreover, this constellation of findings indicated two nodal indolent diseases: CD5+ TCRαβ (n = 13), and CD5+ NK‐cell type lacking TCR expression or clonal TCRγ rearrangement (n = 4). The survival curves for these two groups were significantly superior to others (n = 29, P < .001). These diseases appear to be unique in their indolent clinical behavior, and should be managed differently from other diseases.

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

Reappraisal of nodal Epstein‐Barr Virus‐negative cytotoxic T‐cell lymphoma: Identification of indolent CD5⁺ diseases

et al. 2018

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“…Treatment regimens mainly consisted of various chemotherapy regimens with 33% of patients receiving stem cell transplants. Unfortunately, survival after diagnosis was poor and ranged from 5 d to 3 yr despite therapy (Table 1) [9][10][11][12][13][14] .…”

Section: Discussionmentioning

confidence: 99%

“…Chen et al [9] 2016, Singapore Aiempanakit et al [11] 2017, Thialand 67 y/o, Male Chronic diarrhea and weight loss…”

Section: History Of Celiac Disease? Treatment Prognosis After Diagnosismentioning

confidence: 99%

Truth lies below: A case report and literature review of typical appearing polyps yet with an atypical diagnosis

Fisher¹,

Yousif²,

Piper³

2019

WJGE

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BACKGROUND Enteropathy associated T-cell lymphoma (EATL) is a rare form of peripheral T-cell lymphoma and makes up less than 5% of gastrointestinal lymphomas. EATL can be divided into type 1 which is associated with celiac disease, and monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL), formally type 2, which is not associated with celiac disease. CASE SUMMARY We present a 60-year-old African American female, without celiac disease, who presented with abdominal pain, diarrhea, and 30 lb. weight loss over a 3 month period. She was subsequently diagnosed with EATL throughout her entire gastrointestinal tract. She is currently undergoing chemotherapy with EOCH (Etoposide, Oncovin, Cyclophosphamide, and Hydroxydaunorubicin). EATL is most common in the Asian and Hispanic population yet the incidence in African Americans is uncertain and emphasizes the rarity of this case. A literature review was included to further emphasize similarities and differences between our case and previously reported cases of MEITL. CONCLUSION The patient was diagnosed with EATL, immunochemical testing was not conclusive for MEITL however was suggestive of the disease.

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“…At the cytogenetic level, gains are observed in MYC (locus 8q24) [45]. The staging and prognosis will be carried out in the same way as for the EATL.…”

Section: Diagnosismentioning

confidence: 99%

Extranodal T/NK Lymphomas

Novelli¹

2019

Peripheral T-Cell Lymphomas

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Extranodal T/NK lymphomas comprise infrequent and highly aggressive entities such as extranodal NK/T-cell lymphoma nasal type, enteropathy-associated T-cell lymphoma, monomorphic epitheliotropic intestinal T-cell lymphoma, intestinal T-cell lymphoma NOS, and hepatosplenic T-cell lymphoma. Except for NK/T lymphoma nasal type, there is scarce evidence to support a specific therapeutic regimen in first line and relapse. As the only potentially curative therapy is allogeneic hematopoietic stem cell transplantation, it should be assessed in relapsing/ refractory NK/T lymphoma nasal type and in the first line after remission in the other extranodal NK/T lymphomas.

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Occult recurrence of monomorphic epitheliotropic intestinal T‐cell lymphoma and the role of MATK gene expression in diagnosis

Cited by 15 publications

References 10 publications

Reappraisal of nodal Epstein‐Barr Virus‐negative cytotoxic T‐cell lymphoma: Identification of indolent CD5⁺ diseases

Reappraisal of nodal Epstein‐Barr Virus‐negative cytotoxic T‐cell lymphoma: Identification of indolent CD5⁺ diseases

Truth lies below: A case report and literature review of typical appearing polyps yet with an atypical diagnosis

Extranodal T/NK Lymphomas

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Occult recurrence of monomorphic epitheliotropic intestinal T‐cell lymphoma and the role of MATK gene expression in diagnosis

Cited by 15 publications

References 10 publications

Reappraisal of nodal Epstein‐Barr Virus‐negative cytotoxic T‐cell lymphoma: Identification of indolent CD5+ diseases

Reappraisal of nodal Epstein‐Barr Virus‐negative cytotoxic T‐cell lymphoma: Identification of indolent CD5+ diseases

Truth lies below: A case report and literature review of typical appearing polyps yet with an atypical diagnosis

Extranodal T/NK Lymphomas

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Product

Resources

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Reappraisal of nodal Epstein‐Barr Virus‐negative cytotoxic T‐cell lymphoma: Identification of indolent CD5⁺ diseases

Reappraisal of nodal Epstein‐Barr Virus‐negative cytotoxic T‐cell lymphoma: Identification of indolent CD5⁺ diseases