Occupation and cancer of the oral cavity or oropharynx in Turin, Italy.

Abstract

TERRACINI B. Occupation and cancer of the oral cavity or oropharynx in Turin, Italy. Scand J Work Environ Health 1991;17:248-54. In a population-based case-referent study, the occupational experience of 86 men with oral or oropharyngeal cancer and 373 referents was analyzed with respect to employment in 41 occupations and 40 industries, as well as to exposure to 16 chemicals, as estimated via a job-exposure matrix. Among the occupations and industries at higher risk were machinery operator (odds ratio [OR] 2.0; 95 % confidence interval [95 0/0 CI] 1.0-4.0), plumber (OR 5.0,95 % CI 1.2-21.5), building industry (OR 2.5; 95 % CI 1.3-4.5), textile industry (OR 2.5; 95 % CI 0.6-4.6), and electricity production (OR 2.8; 95 OTo CI 0.7-12.1) . All the OR estimates were adjusted for age, education, area of birth, tobacco smoking, and alcohol consumption. An association between formaldehyde exposure and oral cancer was suggested (OR for any exposure 1.6, 95 OTo CI 0.9-2.8; OR for probable or definite exposure 1.8,. No other chemical included in the matrix showed any risk pattern. The evidence of an association between formaldehyde exposure and oral or oropharyngeal cancer is strengthened by the results of this study .

Formaldehyde exposure and respiratory cancer--a meta-analysis of the epidemiologic evidence.

“…Another case-referent study by Gallagher et al (22) on cancers of the oral cavity and oropharynx provided adjusted figures for "any," as well as "probable or definite" exposure, the latter being used as input for the "substantial" category of exposure. Merletti et al (23) published their case-referent study on cancer of the oral cavity and oroph arynx after the original meta-analysis (1). They provided OR values adjusted for age, education, area of birth in Italy, tobacco smoking, and alcohol consumption.…”

Occupational exposures and head and neck cancers among Swedish construction workers

“…Other suspected risk factors for laryngeal cancer include work in the rubber industry (4,5) and exposure to cement dust (6,7) and asbestos (8)(9)(10)(11). There is little evidence of a relationship between occupational exposures and cancers of the oral cavity and pharynx; some chemicals that have been linked to these cancers include polycyclic aromatic hydrocarbons (12) and formaldehyde (13).…”

“…Workers in the construction industry have been reported to have elevated rates of head and neck cancers in several studies (13)(14)(15)(16)(17)(18)(19), although not in all investigations (20, Purdue et al 21). However, this epidemiologic evidence is generally limited by the absence of information on possibly confounding exposures.…”

Confiabilidade e validade das Declarações de Óbito por câncer de boca no Município de Teresina, Piauí, Brasil, no período de 2004 e 2005

“…Além desses fatores, exposições ocupacionais a substâncias químicas específicas também têm sido apontadas como relacionadas às neoplasias de cavidade oral, tais como: formaldeído 8 , fenoxi herbicidas e dioxinas 9 . Evidências epidemiológicas mostram que exposição ao sol, infecções pelo papiloma vírus humano e vírus herpes simples também podem ser considerados fatores de risco para o câncer de boca 10 .…”