Occupational exposures and head and neck cancers among Swedish construction workers

Purdue, Mark P.; Järvholm, Bengt; Bergdahl, Ingvar A.; Hayes, Richard B.; Baris, Dalsu

doi:10.5271/sjweh.1010

Cited by 84 publications

(64 citation statements)

References 44 publications

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“…For PhC, risk estimates of around one (21,22) as well as increased risks have been reported after asbestos exposure in both overall PhC (23) and hypoPhC (20,24). Our study reported multivariable-adjusted increased HR of PhC for ever versus never exposed to asbestos (HR 2.20, 95% CI 1.08-4.49) when using FINJEM, but a trend of increased risks with higher cumulative exposure could not be demonstrated.…”

Section: Pharyngeal Cancercontrasting

confidence: 63%

“…These studies showed non-significantly increased risks (20,21) as well as decreased risks (22,23), with a recent meta-analysis revealing relative risk (RR) estimates of HR 1.13 (95% CI 0.81-1.57) and HR 1.15 (95% CI 0.84-1.57) for low and high exposure, respectively, based on five studies (3). Risk estimates in our study are in line with the results of the meta-analysis.…”

Section: Oral Cavity Cancermentioning

confidence: 99%

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Occupational asbestos exposure and risk of oral cavity and pharyngeal cancer in the prospective Netherlands Cohort Study

Offermans¹,

Vermeulen²,

Burdorf³

et al. 2014

Scand J Work Environ Health

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Occupational asbestos exposure and risk of oral cavity and pharyngeal cancer in the prospective Netherlands Cohort Study by Offermans NSM, Vermeulen R, Burdorf A, Goldbohm RA, Keszei AP, Peters S, Kauppinen T, Kromhout H, van den Brandt PA Within a population-based study, we estimate the association between occupational asbestos exposure and risk of oral cavity and pharyngeal cancer. There was no convincing evidence of an association between asbestos and risk of both cancers, as an exposure-response relation was lacking. However, the potentially increased hazard ratios of pharyngeal cancer observed in this and previous studies warrant further research. Original article Scand J Work Environ Health. 2014;40(4):420-427. doi:10.5271/sjweh.3434 Occupational asbestos exposure and risk of oral cavity and pharyngeal cancer in the prospective Netherlands Cohort Study Objectives The evidence for an association between occupational asbestos exposure and pharyngeal cancer (PhC) is limited, while for oral cavity cancer (OCC) the literature is even sparser. We studied OCC and PhC risk both separately and combined (OCPC) in relation to occupational asbestos exposure, specifically addressing the influence of potential confounders, the existence of an exposure-response relation, and the presence of interaction between asbestos and smoking. AffiliationMethods Using the prospective Netherlands Cohort Study (N=58 279 men, aged 55-69 years), we estimated asbestos exposure by linkage to a general population job-exposure matrix (DOMJEM) and a Finnish job-exposure matrix (FINJEM). After 17.3 years of follow-up, 58 OCC and 53 PhC cases were available for analysis. ResultsNo association between asbestos and risk of OCC was observed for either JEM. Hazard ratios (HR) of PhC and OCPC increased after adjusting for confounders, particularly alcohol consumption and socioeconomic status. For PhC, a multivariable-adjusted increased HR was observed for "ever" versus "never" exposed to asbestos [HR 2.20, 95% confidence interval (95% CI) 1.08-4.49] when using FINJEM, but a trend of increased risks with higher cumulative exposure could not be demonstrated for either JEM. Results for OCPC showed patterns similar to those observed for PhC. None of the cancers showed a significant interaction between asbestos and smoking.Conclusions This prospective population-based study showed no convincing evidence of an association between asbestos and risk of OCC, PhC, and OCPC as an exposure-response relation was lacking, and results were not robust against the use of different JEM. However, the potentially increased HR of PhC and OCPC observed in this and previous studies warrant further research.

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Section: Pharyngeal Cancercontrasting

confidence: 63%

Section: Oral Cavity Cancermentioning

confidence: 99%

Occupational asbestos exposure and risk of oral cavity and pharyngeal cancer in the prospective Netherlands Cohort Study

Offermans¹,

Vermeulen²,

Burdorf³

et al. 2014

Scand J Work Environ Health

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“…The workers were invited at intervals of 2-5 years (6). Although the program was voluntary, at least 80% of eligible workers participated (7). During the health examination, the workers also answered a questionnaire about their working conditions and health status.…”

Section: Methodsmentioning

confidence: 99%

“…No/Yes". Data (including occupational titles and smoking habits as well as use of snuff) from the health examinations and questionnaires were registered in a database (7).…”

Section: Methodsmentioning

confidence: 99%

White fingers, cold environment, and vibration – exposure among Swedish construction workers

Burström¹,

Järvholm²,

Nilsson³

et al. 2010

Scand J Work Environ Health

Self Cite

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“…O Agricultural Health Study observou um risco aumentado de câncer de pulmão entre aplicadores de agrotóxicos expostos a organoclorados, a dieldrin 35 e a carbamatos 36 . O câncer de pulmão também tem sido associado à exposição ocupacional a metais pesados como níquel, cádmio, cromo hexavalente e berílio 37,38 .…”

Section: Câncer De Pulmão E Mesoteliomaunclassified

Câncer relacionado ao trabalho: uma revisão sistemática

2013

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Cad. Saúde Colet., 2013, Rio de Janeiro, 21 (2): 209-23 209 RevisãoResumo A exposição a substâncias carcinogênicas é reconhecidamente maior nos ambientes de trabalho, e muitas destas foram assim classificadas a partir de estudos epidemiológicos realizados com populações trabalhadoras. O objetivo do estudo foi realizar uma revisão integrativa sobre os principais agentes carcinogênicos presentes no ambiente de trabalho, bem como as principais topografias acometidas por estas substâncias. Foi realizado levantamento nas bases de dados LILACS e MEDLI-NE, cujo termo de busca foi "occupational cancer" e "câncer ocupacional". Observou-se que os artigos apontam para o fato de ser provável que a exposição ambiental/ocupacional à agentes químicos de uma forma geral esteja contribuindo também para o adoecimento da população, sem que uma relação entre causa e efeito seja estabelecida. A difusão de substâncias químicas não ocorre exclusivamente através das conhecidas formas de poluição. Portanto, é de fundamental importância a construção de um sistema de vigilância destes agravos que cumpra dois objetivos principais: a identificação e controle de ambientes de trabalho onde existe potencial exposição à agentes carcinogênicos e a sistematização de informações necessárias à realização de estudos epidemiológicos de caráter exploratório ou analítico.Palavras-chave: câncer; saúde do trabalhador; saúde pública. AbstractExposure to carcinogenic substances is known in most work environments, and many of these were classified as from epidemiological studies on working populations. The objective of this study is an integrative review on the main carcinogens at work environment as well as the main topographies affected by these substances. Survey was conducted in the databases MEDLINE and LILACS, whose term has been "câncer ocupacional" and "occupational cancer". It was observed that the articles point to the fact that it is likely that exposure to environmental/occupational to chemicals in general is also contribute to the disease population, without any relationship between cause and effect is established. The diffusion of chemicals does not occur exclusively through the known forms of pollution. It is therefore of paramount importance to build a surveillance system that meets these injuries two main objectives: to identify and control work environments where there is potential exposure to carcinogenic agents and systematization of information necessary to conduct epidemiological studies, whether exploratory or analytical.

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Occupational exposures and head and neck cancers among Swedish construction workers

Cited by 84 publications

References 44 publications

Occupational asbestos exposure and risk of oral cavity and pharyngeal cancer in the prospective Netherlands Cohort Study

Occupational asbestos exposure and risk of oral cavity and pharyngeal cancer in the prospective Netherlands Cohort Study

White fingers, cold environment, and vibration – exposure among Swedish construction workers

Câncer relacionado ao trabalho: uma revisão sistemática

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