Occupational airborne contact dermatitis from sporadic exposure to tetrazepam during machine maintenance

Airborne occupational contact dermatitis caused by extremely low concentrations of budesonide

“…Approximately 90% of the allergens reported had caused occupational airborne contact dermatitis (2). Recent reports on airborne occupational contact allergy due to pharmaceutical chemicals include tetrazepam, azithromycin, cyanamide and dibenzyl phosphate (4–8). Among adverse skin reactions described to be caused by inhalation of corticosteroids are pruritus, erythema and oedema of the mouth, eczematous lesions, and urticaria (9).…”

Occupational allergic contact dermatitis from tetrazepam in nurses

“…or Myolastan ® crushed tablet as is, 1% aq. and ≥ 10% pet., were negative in 155 control patients (3, 6–8, 11–16).…”

“…Both allergic contact dermatitis and drug eruptions following ingestion of tetrazepam have been described in the literature. In our search (PubMed) we found seven cases of occupational allergic contact dermatitis from tetrazepam: one occurred in a mother crushing Myolastan ® tablets for her daughter (1), three in nurses (2–4), and three in pharmaceutical manufacturing workers (5, 6). All patients suffered from airborne contact dermatitis with lesions on the face and neck, and three of them also had erythema or eczema on the fingers and dorsum of the hands.…”

“…All patients suffered from airborne contact dermatitis with lesions on the face and neck, and three of them also had erythema or eczema on the fingers and dorsum of the hands. One technician had developed a widespread eczematous dermatitis every time he repaired a machine manufacturing Myolastan ® (6).…”

Epidemiological data on airborne contact dermatitis – results of the IVDK

“…Worsening of skin lesions occurred in the work environment, where they had to pulverize tetrazepam tablets with a mortar, leading to the production of drug dust. A case of occupational AirbCD caused by tetrazepam in a repair technician employed in the pharmaceutical industry was reported by Ferran et al (26). Because numerous life-threatening drug reactions after intake of tetrazepam had occurred in the past, the European Commission suspended the registration of drugs containing tetrazepam in January 2013.…”