Occupational allergic contact dermatitis associated with dimethyl fumarate in clothing

Foti, Caterina; Zambonin, Carlo; Cassano, Nicoletta; Aresta, Antonella; Damascelli, Anna; Ferrara, F.; Veña, Gino Antonio

doi:10.1111/j.1600-0536.2009.01567.x

Cited by 24 publications

(15 citation statements)

References 4 publications

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“…It is also a well‐known contact allergen, together with other fumaric acid esters (42, 43). In the case of ‘furniture dermatitis', it was used as a volatile antifungal agent concealed in the finished products such as furniture, textiles, and shoes (44–50).…”

Section: Regulationsmentioning

confidence: 99%

“…In the case of 'furniture dermatitis', it was used as a volatile antifungal agent concealed in the finished products such as furniture, textiles, and shoes (44)(45)(46)(47)(48)(49)(50). Following the outbreak, the EU Commission, assisted by the General Product Safety Directive 2001/95/EC, decided to regulate the use of dimethyl fumarate within the EU.…”

Section: General Product Safety Directive (2001/95/ec) Of Dimethyl Fumentioning

confidence: 99%

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The critical review of methodologies and approaches to assess the inherent skin sensitization potential (skin allergies) of chemicals Part II

et al. 2012

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Section: Regulationsmentioning

confidence: 99%

Section: General Product Safety Directive (2001/95/ec) Of Dimethyl Fumentioning

confidence: 99%

The critical review of methodologies and approaches to assess the inherent skin sensitization potential (skin allergies) of chemicals Part II

et al. 2012

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“…DMFu was generally used as an anti‐mold agent in polyurethane, polyvinyl chloride, and leather products that were directly treated or contained treated packets (often labeled as containing silica gel) . Clothing may also be a source of exposure to DMFu . In some European countries (Germany, Switzerland, and the Netherlands), DMFu is used as a drug for psoriasis treatment, and it is also being investigated for the treatment of multiple sclerosis …”

Section: Introductionmentioning

confidence: 99%

Risk Assessment of Dimethylfumarate Residues in Dwellings Following Contamination by Treated Furniture

et al. 2013

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Recently, numerous cases of dermatitis induced by dimethylfumarate (DMFu) have been reported in Europe. DMFu has been used to prevent mold development in various items, although it is not registered as a biocide. In France, from October 2008 to December 2009, more than 100 cases were reported. Despite a ban on articles containing DMFu and the removal of potentially contaminated products, some people were still suffering from dermatitis or other health problems. The French Agency for Food, Environmental and Occupational Health & Safety was mandated to assess whether the existence in the past of DMFu-contaminated items in dwellings could continue to pose a threat to the health of inhabitants. A risk assessment was performed based on the classical risk analysis approach for environmental contaminants. Hazard assessment of DMFu with regard to its sensitizing properties was performed, based on human case reports collected in France between January 2009 and February 2010. For around half of the 132 individual cases reported, the causal link to DMFu was considered at least probable. An Organisation for Economic Co-Operation and Development (OECD) local lymph node assay performed in a study on mice showed strong sensitizing potential for DMFu. Exposure was assessed by measuring DMFu in items sampled in preselected dwellings. These investigations demonstrated that DMFu exposure can persist after removal of the primary contaminated items. We therefore concluded that there was clearly a risk of skin reactions in patients previously sensitized to DMFu. Furthermore, the available data do not support the existence of significant health effects through the respiratory route.

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“…Patch tesztek segítségével igazolta a DMF oki szerepét, amit más szerzôk is megerôsítettek (5,6,7). Késôbb más országokból is közöltek hasonló, bôrtesztekkel is igazolható DMF allergiát (8,9), újabban pedig DMF-fel impregnált ruházat (10,11), valamint cipô okozta túlérzékenységrôl számolt be több szerzô (12,13,14,15). A betegek egy ré-szénél a súlyos bôrelváltozásokon kívül általános tünetek is jelentkeztek.…”

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Dimethyl-fumarate induced contact allergy

Nagy¹,

Károlyi²

2013

BVSZ

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ÖSSZEFOGLALÁSBevezetés, történeti áttekintés A dimetil-fumarát kontakt allergia aktualitása A globalizáció ütemének felgyorsulásával egyre több olcsó távol-keleti termék áramlik a fejlett országokba, s ezzel párhuzamosan mind gyakrabban találkozunk olyan allergiás betegségekkel, melyek háttere nehezen tisztázható. Ezek egy részét az importált élelmiszerekben természetesen elôforduló allergének okozzák (1), más részüket -a sokszor ellenôrizhetetlen gyártástechnológia során -az ipari termékekbe bekerülô allergének váltják ki. Ez utóbbiak esetében a gyártók ritkán adnak segítséget a gyanúsítható vegyületeket illetôen, így azok identifikálása komoly problémát jelenthet. Elôször 2006-ban figyelték meg, hogy kí-nai ülôbútorok használata során dermatitis alakult ki finn, majd késôbb angol pácienseknél is (2, 3). Az elsô eseteket több száz követte, az irodalom "súlyos contact dermatitis 13

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Occupational allergic contact dermatitis associated with dimethyl fumarate in clothing

Cited by 24 publications

References 4 publications

The critical review of methodologies and approaches to assess the inherent skin sensitization potential (skin allergies) of chemicals Part II

The critical review of methodologies and approaches to assess the inherent skin sensitization potential (skin allergies) of chemicals Part II

Risk Assessment of Dimethylfumarate Residues in Dwellings Following Contamination by Treated Furniture

Dimethyl-fumarate induced contact allergy

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