Occupational allergic contact urticaria from amoxicillin

Condé‐Salazar, L.; Guimaraens, D.; González, M; Mancebo, Eloina Gonzalez

doi:10.1034/j.1600-0536.2001.045002109.x

Cited by 24 publications

(6 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Contact with spilled drugs and inhalation of powder or foam are the most common routes. Exposure by the contact route usually induces contact urticaria (4), anaphylaxis (19), or dermatitis (5), whereas the inhalation route induces most commonly asthma or rhinitis (2, 20). Inhalation can also induce urticaria (1).…”

Section: Discussionmentioning

confidence: 99%

“…Piperacillin is widely used in conjunction with tazobactam, a beta-lactamase inhibitor. Some penicillins have been reported to cause occupational diseases, including bronchial asthma (1, 2), anaphylaxis (3), contact urticaria (4), contact dermatitis (5), and hypersensitivity pneumonitis (6), in pharmaceutical workers and health care professionals. Most of these penicillins belong to the benzylpenicillin or aminopenicillin family.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A Case of Piperacillin-induced Occupational Anaphylaxis: Detection of Serum IgE to Piperacillin-HSA Conjugate

Kim

et al. 2011

J Korean Med Sci

View full text Add to dashboard Cite

This is the first reported detection of serum IgE antibody to piperacillin-human serum albumin (HSA) conjugate in a patient presenting with anaphylaxis that developed after occupational exposure. A 24-yr-old nurse, who had worked at a University Hospital for 2 yr, experienced chest tightness, dizziness, generalized urticaria, abdominal pain, and diarrhea 10 min after administering a piperacillin injection. She had previously suffered from atopic dermatitis. A skin prick test for common inhalant allergens was entirely negative; in contrast, her serum total IgE was elevated (283 IU/mL). A high level of piperacillin-specific serum IgE was detected by ELISA using piperacillin-HSA conjugate. Significant inhibition upon addition of both free piperacillin and piperacillin-HSA conjugate was detected by inhibition ELISA. These data suggest that piperacillin exposure in the workplace can induce occupational anaphylaxis and urticaria mediated by an interaction of IgE with the hapten of piperacillin.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Case of Piperacillin-induced Occupational Anaphylaxis: Detection of Serum IgE to Piperacillin-HSA Conjugate

Kim

et al. 2011

J Korean Med Sci

View full text Add to dashboard Cite

show abstract

“…However, this process involves potential exposure of pharmacy and healthcare workers to the active ingredients, and in 2004, The National Institute for Occupational Safety and Health (NIOSH) warned that "Working with or near hazardous drugs in health care settings may cause skin rashes, infertility, miscarriage, birth defects, and possibly leukemia or other cancers." Indeed, there are many reports of adverse effects, such as wors-ening of asthma (Asai et al, 1987;Bahn et al, 2006;Nakamura et al, 1971), contact dermatitis (Condé-Salazar et al, 2001;Swinnen et al, 2013;Vander Hulst et al, 2010) and rhinitis (Kataura et al, 1973), due to inhalation or contact with airborne particles of drugs, especially those used to treat gastrointestinal and neuropsychiatric disorders and antibiotics. Therefore, the purpose of this study was to estimate the potential exposure of workers to drug particulates during a typical procedure of crushing tablets in a tablet mill and transferring the powder to a mortar.…”

Section: Introductionmentioning

confidence: 99%

Estimation of occupational exposure to drugs during tablet crushing

Maeda

Takahashi²,

Tayama

et al. 2016

Fundam. Toxicol. Sci.

View full text Add to dashboard Cite

In hospitals and pharmacies, many kinds of pharmaceutical tablets are frequently crushed to powder in order to facilitate administration. However, there is concern about the influence of this process on the health of pharmacy workers. In this study, we conducted model experiments to estimate the potential exposure of pharmacy workers to pharmaceutical particles during tablet crushing and transfer of powder. Tablets were crushed in a tablet mill. Particulates released into the air during and after milling and transfer to a mortar were counted with a dust counter, and collected on the filter of an air sampler. Amounts of pharmaceutical active ingredients collected on the filter were determined by high-performance liquid chromatography (HPLC). During tablet crushing, particulates were released into the air. We found that the particle concentration in air was highest during transfer of the powder from the tablet mill to the mortar. The amount of active ingredient collected on the filter of the air sampler was significantly higher in the case of Loxonin, as compared with Neurovitan. Although conditions under which tablets are crushed are likely to vary greatly in practice, our results and calculations at least indicate that unmasked workers might routinely inhale microgram levels of active ingredients during tablet crushing and transfer of the resulting powder. Our results should be helpful in designing appropriate protective measures and in developing professional guidelines to minimize occupational exposure of pharmacy workers to drugs.

show abstract

“…For severe immediate‐type hypersensitivity reactions comprising urticaria, hypotension or shock, drugs have become the most frequent cause followed by insect stings and foods (1). In contrast to beta‐lactam antibiotics (2, 3), true systemic reactions to topical application of local anaesthetics, such as lidocaine, are documented, but remain rather rarely (4).…”

mentioning

confidence: 99%

“…For severe immediate-type hypersensitivity reactions comprising urticaria, hypotension or shock, drugs have become the most frequent cause followed by insect stings and foods (1). In contrast to beta-lactam antibiotics (2,3), true systemic reactions to topical application of local anaesthetics, such as lidocaine, are documented, but remain rather rarely (4). Patient We report on a 63-year-old man without any known allergies who developed general urticaria with pruritus 5 min after topical administration of a lidocaine gel (Dynexan TM ; Kreussler, Wiesbaden, Germany) by his dentist.…”

mentioning

confidence: 99%

Severe contact urticaria to guar gum included as gelling agent in a local anaesthetic

Roesch

Haegele²,

Vogt

et al. 2005

Contact Dermatitis

View full text Add to dashboard Cite

We report the first case of a life-threatening immediate-type hypersensitivity caused by Dynexan, a local anaesthetic gel. After mucosal application by his dentist, a 63-year-old man rapidly developed urticaria, dyspnea and, at last, he collapsed and remained unconscious for 2 hr despite emergency care. While the standard prick tests were negative to all local anaesthetics tested including lidocaine, a 1-fold positive reaction was detected to Meyprogat 60, an ingredient of Dynexan. As the gelling agent Meyprogat represents a derivative of guar (synonymous guar gum, guaran, E-412), we subsequently tested different guar products derived from Cyamopsis tetragonoloba beans and, as control, the closely related locust bean gum E-410. In the prick-to-prick tests, the guar-derived food additive Provigel NAG 905 provoked a 1-fold positive reaction. Native guar beans pounded and resuspended in water showed a 2-fold positive reaction, whereas no reaction was found to derivatives of locust bean gum. Specific immunoglobulin E were negative in all cases. Despite the common use of guar as versatile food additive or gelling agent, this is the first case of a severe immediate-type hypersensitivity after mucosal contact.

show abstract

Occupational allergic contact urticaria from amoxicillin

Cited by 24 publications

References 3 publications

A Case of Piperacillin-induced Occupational Anaphylaxis: Detection of Serum IgE to Piperacillin-HSA Conjugate

A Case of Piperacillin-induced Occupational Anaphylaxis: Detection of Serum IgE to Piperacillin-HSA Conjugate

Estimation of occupational exposure to drugs during tablet crushing

Severe contact urticaria to guar gum included as gelling agent in a local anaesthetic

Contact Info

Product

Resources

About