Occupational and residential exposure to electromagnetic fields and risk of brain tumors in adults: A case–control study in Gironde, France

Baldi, Isabelle; Coureau, Gaëlle; Jaffré, Anne; Gruber, A.; Ducamp, Stéphane; Provost, D.; Lebailly, Pierre; Vital, Anne; Loiseau, Hugues; Salamon, Roger

doi:10.1002/ijc.25765

Cited by 60 publications

(33 citation statements)

References 44 publications

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“…Also to be remembered, MRI use does not only differ between geographical regions and time periods as assessed in the present study, but presumably also varies with health complaints, among socioeconomic groups, genders, age groups, and not at least depends on MRI availability. Thus, differences in MRI use may act as a possible confounder in comparative studies concerning potential carcinogenic exposures, such as the use of mobile telephones, 4,10 exposure to other electromagnetic fields, 1,8 or air pollution. 13 The main strength of the present population-based study is the quality and completeness of the registrybased data.…”

Section: Discussionmentioning

confidence: 99%

Effects of cerebral magnetic resonance imaging in outpatients on observed incidence of intracranial tumors and patient survival: a national observational study

Solheim

Torsteinsen

Johannesen

et al. 2014

JNS

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M agnetic resonance imaging has clearly revolutionized many fields of medicine, not least neurology, neuro-oncology, and neurosurgery. Today, diagnosing or ruling out intracranial disease without a cerebral MRI scan is exceedingly rare, and perhaps even no longer recommended. However, the toll for patients can be incidental findings. In asymptomatic volunteers, incidental abnormalities were seen in 18% of cerebral MRI scans, and 2.9% required further referral.7 In another study, 1.6% of healthy volunteers who underwent 1.5-T cerebral MRI scans were diagnosed with primary, most often benign tu- mors.18 It is often speculated that the increase in brain tumor incidence observed over recent decades may at least partially be explained by increased use of MRI. 2,3,5,6,[14][15][16] However, a direct population-based comparison of MRI use and brain tumor incidence rates is lacking.In a population-based study we aimed to investigate whether regional cerebral MRI use correlates to regional incidence of intracranial tumors as reported to the Cancer Registry of Norway. We also sought to study whether a possible effect of MRI on observed brain tumor incidence has affected treatment rates or observed patient survival.Effects of cerebral magnetic resonance imaging in outpatients on observed incidence of intracranial tumors and patient survival: a national observational study Object. It is assumed that the observed increase in brain tumor incidence may at least partially be explained by increased use of MRI. However, to date no direct estimate of this effect is available. The authors undertook this registry-based study to examine whether regional frequencies of cerebral MRI use correlate to regional incidence rates of intracranial tumors and survival of patients with these lesions.Methods. The authors used Norwegian national population registries from January 2002 through December 2007 to conduct this observational study. They obtained information on outpatient MRI scans in Norwegian counties and examined whether the annual regional rates of cerebral MRI scans correlated to regional age-and sex-adjusted brain tumor incidence rates. They also explored whether differences in cerebral MRI use were associated with survival and examined time trends in the study period.Results. Approximately 50,000 cerebral MRI scans are carried out annually in outpatient settings in Norway, and 6363 primary intracranial tumors were diagnosed in Norway during the study period. There was an overall positive correlation between the annual number of cerebral MRI scans per 100,000 capita and age-and sex-adjusted incidence rates of intracranial tumors in the various Norwegian counties (Spearman's rho = 0.35, p < 0.001). In a linear model, an increase in 1 MRI per 100,000 capita per year results in a 0.004 (95% CI 0.002-0.006) increase in diagnosed intracranial tumors per 100,000 capita per year (p < 0.001). Subgroup analysis showed a correlation between MRI use and the annual age-and sex-adjusted incidence rates of extraaxial tumors (p = 0.04, Spearman's ...

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Section: Discussionmentioning

confidence: 99%

Effects of cerebral magnetic resonance imaging in outpatients on observed incidence of intracranial tumors and patient survival: a national observational study

Solheim

Torsteinsen

Johannesen

et al. 2014

JNS

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“…Laboratory and epidemiological studies have pointed out that EMF could cause disorder in cardiovascular and central nervous system, and also play roles in the occurrence of cancer (Baldi et al, 2011;Jeong et al, 2005;Johansen, 2000). Sharifian, Gharavi, Pasalar, & Aminian (2009) reported that extremely low frequency magnetic field (ELF-MF) affects the human antioxidant activity.…”

Section: Introductionmentioning

confidence: 99%

Effects of extremely low frequency electromagnetic field on the health of workers in automotive industry

Liu¹,

Zhao²,

et al. 2013

Electromagnetic Biology and Medicine

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“…The topic is under public scrutiny as it is a considerable environmental issue, with nearly all of civilized world being exposed to some forms of EMF from either natural or artificial sources. A study in France showed that occupational and residential exposure to EMF might play a role in the occurrence of meningioma (Baldi et al 2011). Another study in Sweden assessed the potential dangers of exposure to EMF, and suggested a possible relationship between parental occupational exposure to EMF and the incidence of leukemia (Feychting et al 2000).…”

Section: Introductionmentioning

confidence: 99%

Effects of exposure to extremely low-frequency electromagnetic fields on the differentiation of Th17 T cells and regulatory T cells

Lee

Hyung²,

Yoo³

et al. 2016

gpb

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Abstract. The potential risks that electromagnetic fields (EMF) pose to human physiology have been debated for several decades, especially considering that EMF is almost omnipresent and some occupations involve regular exposure to particularly strong fields. In the present study, the effects of 60 Hz 0.3 mT EMF on CD4 + T cells were evaluated. Production of T cell related cytokines, IFN-γ and IL-2, was not altered in CD4 + T cells that were exposed to EMF, and cell proliferation was also unaffected. The expression of genes present in a subset of Th17 cells was upregulated following EMF exposure, and the production of effector cytokines of the IL-17A subset also increased. To determine signaling pathways that underlie these effects, phosphorylation of STAT3 and SMAD3, downstream molecules of cytokines critical for Th17 induction, was analyzed. Increased SMAD3 phosphorylation level in cells exposed to EMF, suggesting that SMAD3 may be at least in part causing the increased Th17 cell production. Differentiation of Treg, another CD4 + T cell subset induced by SMAD3 signaling, was also elevated following EMF exposure. These results suggest that 60 Hz 0.3 mT EMF exposure amplifies TGF-β signaling and increases the generation of specific T cell subsets.

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Occupational and residential exposure to electromagnetic fields and risk of brain tumors in adults: A case–control study in Gironde, France

Cited by 60 publications

References 44 publications

Effects of cerebral magnetic resonance imaging in outpatients on observed incidence of intracranial tumors and patient survival: a national observational study

Effects of cerebral magnetic resonance imaging in outpatients on observed incidence of intracranial tumors and patient survival: a national observational study

Effects of extremely low frequency electromagnetic field on the health of workers in automotive industry

Effects of exposure to extremely low-frequency electromagnetic fields on the differentiation of Th17 T cells and regulatory T cells

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