“…2 Several cases have been reported in the literature in which concomitant (delayed) contact sensitivity is observed to colophonium and to a Juniperus species/cultivar or another member of the Cupressaceae family (eg, × Cupressocyparis leylandii). [3][4][5][6] However, the reaction been recognized that Juniperus species can be a source of these substances, 9 and these well-known irritants have been reported from J. communis. 10,11 These lignans appear to be secondary metabolites produced by endophytic fungi 12,13 that colonize the roots when the plant is stressed, so the levels of these lignans are likely to vary.…”