Occupational exposure parameters for characterization of nanoparticulate matter toxicity: Metal versus wood processing

Pavlovska, Ilona; Martinsone, Žanna; Vanadziņš, Ivars; Mārtiņsone, Inese; Seile, Anita; Sudmalis, P

doi:10.1016/j.psep.2016.03.018

Cited by 19 publications

(31 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Particles from the metalworking industry comprised Fe > C > Si > Ca > Zn > Cr > Mn (in decreasing order), while particles from the wood processing industry comprised C > Si > Ca > Fe > Mo > Na. The predominant elements were carbon and oxygen, and there were also traces of chlorine and sulphur that possibly originated from organic compounds or from inorganic oxides, acids and salts (Pavlovska et al 2016 ).…”

Section: Resultsmentioning

confidence: 99%

“…For example, in the case of particle mass concentration, it is clear that exposure is very high in the range of inhalable particles. However, in the case of particle number concentration, it is very high in range of respirable, fine or ultrafine particles (Pavlovska et al 2016 ). Currently, total dust, inhalable and respirable dust mass concentrations are used to describe the whole impact to workers’ health, but there are many discussions on particle number concentration as a better parameter for the characterization of workers’ health effects.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The effect of different workplace nanoparticles on the immune systems of employees

et al. 2017

Self Cite

View full text Add to dashboard Cite

Currently, nanoparticles are widely present in the environment and are being used in various industrial technologies. Nanoparticles affect immune functions, causing different immune responses. The aim of the current study was to evaluate several cytokines, interleukin (IL)-1b, IL-6, IL-8, tumour necrosis factor-a (TNF-α), interferon-γ, adhesive molecule sICAM-1, macrophage inhibitory protein 1a (MIP1a) and secretory immunoglobulin A, in nasal lavage fluid and in the peripheral blood of healthy subjects exposed to workplace nanoparticles. Thirty-six employees from three different environments were examined: 12 from a metalworking company, 12 from a woodworking company and 12 office workers. The nanoparticles in the different workplaces were detected in the air in the immediate vicinity of the employees. The particle number concentration and surface area values were significantly higher in the workplaces of the metal- and woodworking industries, but concentrations of mass were lower (the measurements were performed by an electrical low-pressure impactor ELPI+). Energy dispersive X-ray spectroscopy (EDS, an attachment to a high-resolution SEM) was used to provide elemental analysis or chemical characterization of the dust particles in a low-vacuum field-free mode operating at a potential of 15 kV spot 3.0. The technique used provided quantitative and spatial analyses of the distribution of elements through mapping (two to three parallel measurements) and point analysis (four to five parallel measurements). Samples from the metal industry contained more ultramicroscopic and nanometric particles, e.g. toxic metals such as Zn, Mn and Cr, and fewer microscopic dust particles. The nasal lavage and peripheral blood were taken at the beginning and the end of the working week, when immune indices were measured. Our data showed a statistically significant increased level of the pro-inflammatory cytokine TNF-α in serum in both exposed groups compared with office workers as well as a higher level of TNF-α in workers from the woodworking company compared with the metalworking employees. We found an elevated level of IL-6 in the exposed groups as well as an elevated level of IL-8 in the nasal lavage in woodworking employees after work.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The effect of different workplace nanoparticles on the immune systems of employees

et al. 2017

Self Cite

View full text Add to dashboard Cite

show abstract

“…Airborne particulates from an 8 h work shift were collected from around the working zones close to the workers in two environments: the metalworking industry (M), to assess the processes related to welding (shielded metal arc welding) and milling, in which many particles are released in the nanoscale range (<100 nm), and the woodworking industry (W), where grinding and polishing processes were used to assess organic particles. The size, shape, quantity, and chemical compositions of nanoparticles were detailed in previous work on the occupational exposure parameters for the characterization of nanoparticulate matter toxicity and a comparison of the biological markers in aerosol-weighed workplaces [17,18,19]. These studies showed the presence of all three types of dust, microscopic, ultramicroscopic, and nanometric (< 100 nm, containing inorganic and organic dusts, as well as toxic elements like Zn, Si, Fe, Mn, and Cr).…”

Section: Collection and Measurement Of The Particlesmentioning

confidence: 99%

In Vitro Impact Preliminary Assessment of Airborne Particulate From Metalworking and Woodworking Industries

Pavlovska¹,

Ramata-Stunda²,

Martinsone³

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

Inhalation is the main route of exposure to airborne pollutants. To evaluate the safety and assess the risks of occupational hazards different testing approaches are used. 3D airway epithelial tissues allow to mimic exposure conditions in vitro, generates human-relevant toxicology data, allows to elucidate mode of action of pollutants. Gilian 3500 pumps equipped with Standard Midget Impingers were used to collect the airborne particulate from woodworking and metalworking environments. EpiAirway™ tissues were used to model half working day (4 h), full working day (8 h), and 3 working day exposures to occupational pollutants. Tissue viability was assessed using MTT assay. RT-qPCR analyses performed to analyze the expression of gelsolin, caspase-3, and IL-6. Tissue morphology was assessed by hematoxylin/eosin staining. Acute exposure to workspace pollutants slightly affected tissue viability and did not change the morphology. Both types of particles suppressed expression of gelsolin, with metalworking samples showing the most pronounced effect. A slight reduction in caspase-3 expression was observed. Particles from metalworking suppressed IL-6 expression. 3D Epithelial tissues can be used to model exposures to airborne pollutants. Exposure to particles from woodworking and metalworking had a minor effect on tissue viability but affected the expression of inflammation and apoptosis-related genes.

show abstract

“…All of the main inorganic elements constituting the particles were present, including sodium, calcium, silicon, iron, magnesium, manganese, zinc, and chromium, as well as chlorine, potassium, and sulphur. Dust particles comprise all size groups according to the dispersity: visible (> 10 μm), microscopic (0.25-10 μm), ultramicroscopic (< 0.25 μm), and nanometric (1-100 nm) dust (Pavlovska et al 2016). Particles from the metal industry samples contain more dust of ultramicroscopic and nanometric sizes and less dust of the microscopic size (both inorganic and organic) already on particles from stage 2.…”

Section: Dust Particle Measurementsmentioning

confidence: 99%

Comparison of biological markers in aerosol-weighed workplaces

et al. 2019

Self Cite

View full text Add to dashboard Cite

Airborne particulates present a potential hazard to health in a variety of indoor workplaces, from offices to the manufacturing floor. Dust and aerosols are two of the most common occupational risk factors in the workplace worldwide. It is very important to understand when it is sufficient to describe dust exposure only by given mass concentration that dust particles could be in the nanosized range in the workplace air even for brief exposures, such as welding aerosols. The main objective was to assess total dust and nanoparticle concentrations in the selected workplaces and to evaluate their impact on workers' health.

show abstract

Occupational exposure parameters for characterization of nanoparticulate matter toxicity: Metal versus wood processing

Cited by 19 publications

References 13 publications

The effect of different workplace nanoparticles on the immune systems of employees

The effect of different workplace nanoparticles on the immune systems of employees

In Vitro Impact Preliminary Assessment of Airborne Particulate From Metalworking and Woodworking Industries

Comparison of biological markers in aerosol-weighed workplaces

Contact Info

Product

Resources

About