Occupational Exposure to Aflatoxin (AFB<sub>1</sub>) in Poultry Production

Viegas, Susana; Veiga, Luísa; Malta-Vacas, Joana; Sabino, Raquel; Figueredo, Paula; Almeida, Ana; Viegas, Carla; Carolino, Elisabete

doi:10.1080/15287394.2012.721164

Cited by 78 publications

(66 citation statements)

References 45 publications

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“…Additionally, the fact that particles may act as a carrier and a source of nutrients for fungi (such as Aspergillus, Penicillium and Mucor genus) [41] and bacteria [3] also have to be considered. To this end we have to consider that larger particles fractions, such as fungi, are the most relevant ones for allergen exposure [42] and this claims attention to the fact that even particles from 5 µm and 10 µm sizes are relevant since they are the best carriers for fungi and other allergens present in the workplace.…”

Section: Discussionmentioning

confidence: 99%

Occupational exposure to fungi and particles in animal feed industry

Viegas

Faria

Carolino

et al. 2016

Med Pr

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Background: Very few studies regarding fungal and particulate matter (PM) exposure in feed industry have been reported, although such contaminants are likely to be a significant contributing factor to several symptoms reported among workers. The purpose of this study has been to characterize fungal and dust exposure in one Portuguese feed industry. Material and Methods: Air and surface samples were collected and subject to further macro-and microscopic observations. In addition we collected other air samples in order to perform real-time quantitative polymerase chain reaction (PCR) amplification of genes from Aspergillus fumigatus and Aspergillus flavus complexes as well as Stachybotrys chartarum. Additionally, two exposure metrics were considered -particle mass concentration (PMC), measured in 5 different sizes (PM 0.5 , PM 1 , PM 2.5 , PM 5 , PM 10 ), and particle number concentration (PNC) based on results given in 6 different sizes in terms of diameter (0.3 µm, 0.5 µm, 1 µm, 2.5 µm, 5 µm and 10 µm). Results: Species from the Aspergillus fumigatus complex were the most abundant in air (46.6%) and in surfaces, Penicillium genus was the most frequently found (32%). The only DNA was detected from A. fumigatus complex. The most prevalent in dust samples were smaller particles which may reach deep into the respiratory system and trigger not only local effects but also the systemic ones. Conclusions: Future research work must be developed aiming at assessing the real health effects of these co-exposures. Med Pr 2016;67(2):143-154

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Section: Discussionmentioning

confidence: 99%

Occupational exposure to fungi and particles in animal feed industry

Viegas

Faria

Carolino

et al. 2016

Med Pr

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“…A variety of chemicals comprising VCM, organic solvents, chlorinated pesticides and arsenic exert adverse effects on the liver [97] (Tables 2 and 3). [4,38,41,44] , waste operators [38,44] Group 1 [34] HCV -Health care workers [38,39,61] Group 1 [34] Aflatoxin B1 1162-65-8 Paper mill and sugar factory; poultry production; rice mill; waste management; swine industry; agri-food industry; wheat handling; textile manufacturing [77,78,[87][88][89][90][91]93,96] Group 1 [76] IARC: International Agency for Research on Cancer; CAS No. : Chemical abstract service number; HBV: Hepatitis B virus; HCV: Hepatitis C virus.…”

Section: Non-infective Risk Factors For Hepatocellular Carcinomamentioning

confidence: 99%

“…This could be caused by the aflatoxin ability to determine the mutation of the p53 tumor suppressor gene, which in normal conditions induces the apoptosis processes [74][75][76][77] . The risk of HCC increases when the exposure occurs in the presence of HBV infection, as occurs in the Chinese population [78][79][80][81][82][83][84][85][86][87][88][89][90][91][92][93][94][95][96] .…”

Section: Aflatoxinsmentioning

confidence: 99%

Hepatocellular carcinoma and the risk of occupational exposure

Rapisarda

Loreto

Malaguarnera

et al. 2016

WJH

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Hepatocellular carcinoma (HCC) is the most common type of liver cancer. The main risk factors for HCC are alcoholism, hepatitis B virus, hepatitis C virus, nonalcoholic steatohepatitis, obesity, type 2 diabetes, cirrhosis, aflatoxin, hemochromatosis, Wilson's disease and hemophilia. Occupational exposure to chemicals is another risk factor for HCC. Often the relationship between occupational risk and HCC is unclear and the reports are fragmented and inconsistent. This review aims to summarize the current knowledge regarding the association of infective and non-infective occupational risk exposure and HCC in order to encourage further research and draw attention to this global occupational public health problem. Core tip: Hepatocellular carcinoma (HCC) is the fifth most common human cancer. This review summarizes current knowledge regarding the occupational risk factors of HCC. In particular, we underline not only the infective but also non-infective occupational risk exposure, including chemical agents and toxic metabolites which are a major cause of liver damage.

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“…Bioaerosol containing mycotoxins may be encountered in occupation and private life (in working and living environment). Occupational exposure is connected with processing and storing of crops, feeding of animals, production of foodstuffs, raising of animals and production of animal fodder, composting, biotechnology, work in such buildings as museums, libraries, archives and offices which are affected by moldiness [16,[28][29][30][31][32]. Mycotoxins in IJOMEH 2016;29(5) 825 the plates with the medium were subjected to further processing according to the procedure described below.…”

Section: Methodsmentioning

confidence: 99%

The capability of fungi isolated from moldy dwellings to produce toxins

Jeżak¹,

Kozajda²,

Sowiak³

et al. 2016

Int J Occup Med Environ Health

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Objectives:The main objective was analysis and assessment of toxinogenic capabilities of fungi isolated from moldy surfaces in residential rooms in an urban agglomeration situated far from flooded areas in moderate climate zone. Material and Methods: The assessment of environmental exposure to mycotoxins was carried out in samples collected from moldy surfaces in form of scrapings and airborne dust from 22 moldy dwellings in winter season. In each sample 2 mycotoxins were analyzed: sterigmatocystin and roquefortine C produced by Aspergillus versicolor and Penicillium chrysogenum, respectively. Mycotoxins were analyzed by high-performance liquid chromatography (HPLC) in: scrapings from moldy surfaces, mixture of all species of fungi cultured from scrapings on microbiological medium (malt extract agar), pure cultures of Aspergillus versicolor and Penicillium chrysogenum cultured from scrapings on microbiological medium; mycotoxins in the indoor air dust were also analyzed. Results: The production of sterigmatocystin by individual strains of Aspergillus versicolor cultured on medium was confirmed for 8 of 13 isolated strains ranging 2.1-235.9 μg/g and production of roquefortine C by Penicillium chrysogenum for 4 of 10 strains ranging 12.9-27.6 μg/g. In 11 of 13 samples of the mixture of fungi cultured from scrapings, in which Aspergillus versicolor was found, sterigmatocystin production was at the level of 3.1-1683.2 μg/g, whereas in 3 of 10 samples in which Penicillium chrysogenum occurred, the production of roquefortine C was 0.9-618.9 μg/g. The analysis did not show in any of the tested air dust and scrapings samples the presence of analyzed mycotoxins in the amount exceeding the determination limit. Conclusions: The capability of synthesis of sterigmatocystin by Aspergillus versicolor and roquefortine C by Penicillium chrysogenum growing in mixtures of fungi from scrapings and pure cultures in laboratory conditions was confirmed. The absence of mycotoxins in scrapings and air dust samples indicates an insignificant inhalatory exposure to mycotoxins among inhabitants in moldy flats of urban agglomeration situated far from flooded territories. Int J Occup Med Environ Health 2016;29(5): [823][824][825][826][827][828][829][830][831][832][833][834][835][836]

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Occupational Exposure to Aflatoxin (AFB₁) in Poultry Production

Cited by 78 publications

References 45 publications

Occupational exposure to fungi and particles in animal feed industry

Occupational exposure to fungi and particles in animal feed industry

Hepatocellular carcinoma and the risk of occupational exposure

The capability of fungi isolated from moldy dwellings to produce toxins

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Occupational Exposure to Aflatoxin (AFB1) in Poultry Production

Cited by 78 publications

References 45 publications

Occupational exposure to fungi and particles in animal feed industry

Occupational exposure to fungi and particles in animal feed industry

Hepatocellular carcinoma and the risk of occupational exposure

The capability of fungi isolated from moldy dwellings to produce toxins

Contact Info

Product

Resources

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Occupational Exposure to Aflatoxin (AFB₁) in Poultry Production