Occupational exposure to endocrine-disrupting chemicals and the risk of uveal melanoma

Occupational Cooking and Risk of Uveal Melanoma: a Meta-analysis

“…Five casecontrol studies involving a total of 1199 cases and 6927 controls were included into the meta-analysis (Guenel et al, 2001;Stang et al, 2003;Lutz et al, 2005;SchmidtPokrzywniak et al, 2010;Behrens et al, 2011). Overall, occupational cooking was associated with increased risk of uveal melanoma (OR = 1.81, 95%CI 1.33-2.46, P < 0.001).…”

“…Of these, the majority were excluded after the first screening based on abstracts or titles, mainly because they were reviews, case reports, or not relevant to our analysis. 9 full-text publications were preliminarily included into this meta-analysis (Ajani et al, 1992;Holly et al, 1996;Guenel et al, 2001;Monarrez-Espino et al, 2002;Stang et al, 2003;Lutz et al, 2005;Schmidt-Pokrzywniak et al, 2009;Schmidt-Pokrzywniak et al, 2010;Behrens et al, 2011). After full-text review of those 9 papers, 2 studies were excluded because they contained overlapping data (Monarrez-Espino et al, 2002;Schmidt-Pokrzywniak et al, 2009), and another studies excluded because they were lack of necessary data (Ajani et al, 1992;Holly et al, 1996).…”

“…After full-text review of those 9 papers, 2 studies were excluded because they contained overlapping data (Monarrez-Espino et al, 2002;Schmidt-Pokrzywniak et al, 2009), and another studies excluded because they were lack of necessary data (Ajani et al, 1992;Holly et al, 1996). Thus, five case-control studies involving a total of 1199 cases and 6927 controls were finally included into our meta-analysis (Guenel et al, 2001;Stang et al, 2003;Lutz et al, 2005;Schmidt-Pokrzywniak et al, 2010;Behrens et al, 2011). These studies were published between 2001 and 2011.…”

Epigenetic marks responsible for cadmium-induced melanoma cell overgrowth

“…It has been hypothesized that some trace elements of toxicological interest may be implicated in the etiology of melanoma. However, from the literature review emerges a picture of conflicting results on the involvement of Cd in this tumor, although an association has been found between exposure to Cd and uveal melanoma (Behrens et al, 2012). In some ways, it was ruled out the role of Cd in the pathogenesis of cutaneous melanoma Vinceti et al, 2005), while in other respects, the few papers available provide evidence that increased resistance to this heavy metal is associated…”

Uveal Melanoma: Epidemiologic Aspects

“…In an exploratory study, agriculture and farming work was associated with uveal melanoma, but specifi c exposure to a group of chemicals could not be clearly identifi ed [ 70 ]. Other agents that have been investigated include electromagnetic fi elds [ 71 ], endocrine-disrupting chemicals [ 72 ], pesticides [ 73 ], artifi cial hormones [ 74 ], and mobile phones [ 75 ]. Additionally, no association between season of birth and uveal melanoma has been found [ 76 ].…”