Occupational exposure to ionizing and non-ionizing radiation and risk of glioma

Karipidis, Kyriakos; Benke, Geza; Sim, Malcolm Ross; Kauppinen, Timo; Giles, Graham G.

doi:10.1093/occmed/kqm078

Cited by 36 publications

(22 citation statements)

References 26 publications

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“…Although the etiology of the higher IR observed in this area remains obscure, it could be partially related to undetermined environmental factors such as higher exposure to sun and ultraviolet radiation [30] . Further studies are needed to investigate the influence of specific environmental factors and the genetic alterations in this area as predisposing to cerebral gliomas.…”

Section: Discussionmentioning

confidence: 99%

Descriptive Epidemiology of Cerebral Gliomas in Northwest Greece and Study of Potential Predisposing Factors, 2005–2007

et al. 2009

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Background: To investigate the epidemiologic and clinical characteristics (age, sex, tumor location, socioeconomic status) and potential predisposing factors (alcohol, tobacco, mobile phone use, severe head trauma) of cerebral gliomas in a defined area of Northwest Greece. Methods: The prospective study was conducted in patients with gliomas referred to all 7 hospitals of a study area with a population of 488,435 inhabitants, from June 1, 2005, to May 31, 2007. Incidence rates (IR) were calculated as new cases diagnosed among residents of the study area during the study period per 100,000 inhabitants. A case-control study was carried out in order to study the possible association of the risk of glioma with smoking, alcohol, use of mobile phone, and severe cranial trauma. Results: A total of 56 glioma incident cases were identified with IRs of glioma and glioblastoma (GBM) at 5.73/10⁵/year and 3.69/10⁵/year, respectively. A male to female ratio of 1.25 was obtained in the GBM group. IRs of glioma and GBM for both males and females were higher in the age group 60–79. The most frequent anatomic location was the frontal lobe. 46.5% of the patients originated from the low, 25% from the middle and 28.5% from the high socioeconomic class. There was no significant association between glioma and alcohol consumption, smoking and mobile phone use. A trend for a positive association between the risk of glioma and a history of severe cranial trauma was observed, but this association was not statistically significant. Conclusion: The estimated IR of glioma and GBM in this study was higher compared with data from other studies carried out on European, Asian and US populations. Further studies may be needed to assess the possible association of genetic, environmental and lifestyle factors with the high occurrence of gliomas observed in this study.

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Section: Discussionmentioning

confidence: 99%

Descriptive Epidemiology of Cerebral Gliomas in Northwest Greece and Study of Potential Predisposing Factors, 2005–2007

et al. 2009

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“…Although a possible association between low level medical IR exposure and the risk of brain tumors has been suggested (45, 46), occupational exposure to low IR levels and the risk of brain tumors remains, however, not very consistent (45, 47, 48). In the current study, ten study subjects reported medical exposure to IR (for treatment of conditions such as acne, birth mark, and hyperthyroidism) while the remaining 46 were occupationally exposed (occupations such as physicians, radiologists, nurses, pilots and engineers).…”

Section: Discussionmentioning

confidence: 99%

Association and Interactions between DNA Repair Gene Polymorphisms and Adult Glioma

Liu¹,

Scheurer

El‐Zein³

et al. 2009

Cancer Epidemiology, Biomarkers &Amp; Prevention

122

120

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It is generally accepted that glioma develops through accumulation of genetic alterations. We hypothesized that polymorphisms of candidate genes involved in the DNA repair pathways may contribute to susceptibility to glioma. To address this possibility, we conducted a study on 373 Caucasian glioma cases and 365 cancer-free Caucasian controls to assess associations between glioma risk and 18 functional single-nucleotide polymorphisms in DNA repair genes. We evaluated potential gene-gene and gene-environment interactions using a multianalytic strategy combining logistic regression, multifactor dimensionality reduction and classification and regression tree approaches. In the single-locus analysis, six single-nucleotide polymorphisms [ERCC1 3 ¶ untranslated region (UTR), XRCC1 R399Q, APEX1 E148D, PARP1 A762V, MGMT F84L, and LIG1 5 ¶UTR] showed a significant association with glioma risk. In the analysis of cumulative genetic risk of multiple single-nucleotide polymorphisms, a significant genedosage effect was found for increased glioma risk with increasing numbers of adverse genotypes involving the aforementioned six single-nucleotide polymorphisms (P trend = 0.0004). Furthermore, the multifactor dimensionality reduction and classification and regression tree analyses identified MGMT F84L as the predominant risk factor for glioma and revealed strong interactions among ionizing radiation exposure, PARP1 A762V, MGMT F84L, and APEX1 E148D. Interestingly, the risk for glioma was dramatically increased in ionizing radiation exposure individuals who had the wild-type genotypes of MGMT F84L and PARP1 A762V (adjusted odds ratios, 5.95; 95% confidence intervals, 2.21-16.65). Taken together, these results suggest that polymorphisms in DNA repair genes may act individually or together to contribute to glioma risk.

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“…38 Gender differences were also observed in an Australian occupational case-control study that found an inverse association between occupational UV exposure and risk of glioma in females (OR= 0.54; 95% CI= 0.27-1.07) while there was a positive association among males (OR= 1.60; 95% CI= 0.95-2.69). 39 Alternatively, gender differences may also be due to misclassification of occupational exposure due to behavioral differences, such as a higher tendency for females to use sunscreen on a regular basis and the ability of males to work outdoors while shirtless. 40 Around the world (with a few exceptions) males generally tend to go outside more frequently, spend more time outdoors and therefore acquire higher UV doses than females.…”

Section: Discussionmentioning

confidence: 99%

Occupational sunlight exposure and risk of renal cell carcinoma

Karami

Boffetta

Stewart

et al. 2010

Cancer

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BACKGROUND: Recent findings indicate that vitamin D obtained from ultraviolet (UV) exposure may reduce the risk of several different cancers. Vitamin D is metabolized to its active form within the kidney, which is the major organ for vitamin D metabolism and activity. Because both the incidence of renal cell carcinoma (RCC) and the prevalence of vitamin D deficiency have increased over the past few decades, in the current study, the authors explored whether occupational UV exposure was associated with RCC risk. METHODS: A hospital-based, case-control study of 1097 patients with RCC (cases) and 1476 controls was conducted in 4 Central and Eastern European countries. Demographic and occupational information was collected to examine the association between occupational UV exposure and RCC risk. RESULTS: A significant reduction (24%-38%) in the risk of RCC was observed with increasing occupational UV exposure among men who participated in the study. No association between UV exposure and RCC risk was observed among women who participated. When the analyses were stratified by latitude as another estimate of sunlight intensity, a stronger reduction (71%-73%) in the risk of RCC was observed between UV exposure and cancer risk among men who resided at the highest latitudes. CONCLUSIONS: The current results suggested that, among men, there is an inverse association between occupational UV exposure and the risk of RCC. Replication studies are warranted to confirm these results.

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Occupational exposure to ionizing and non-ionizing radiation and risk of glioma

Cited by 36 publications

References 26 publications

Descriptive Epidemiology of Cerebral Gliomas in Northwest Greece and Study of Potential Predisposing Factors, 2005–2007

Descriptive Epidemiology of Cerebral Gliomas in Northwest Greece and Study of Potential Predisposing Factors, 2005–2007

Association and Interactions between DNA Repair Gene Polymorphisms and Adult Glioma

Occupational sunlight exposure and risk of renal cell carcinoma

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