Nowadays, the combination of “Nanotechnology” and “Ergonomics” has been known as “Nano‐ergonomics.” Nano‐ergonomics can help to develop more comfortable conditions in workplaces. So, the aim of this study is to reveal benefits of nanotechnology for occupational health and safety design, especially ergonomic design. The search strategy was provided based on cochrane guidelines with main search terms of “Nanotechnology,” “Nanomaterial,” and “Nanoparticle” combined with “Ergonomics” and “Human Factors.” PubMed, Scopus, Web of Sciences and Google Scholar Databases were researched for relevant articles. Also, Google search engine was used to find nano‐ergonomic commercial products and to complete the research with identifying additional information. A total of 32 articles were first achieved. By providing Synthesis Without Meta‐analysis reporting guideline, finally, four studies were regarded as appropriate. The results showed that nanotechnology has developed in three major areas of ergonomics such as physical, environmental, and cognitive ergonomics, which is a positive step toward more protection of workers' health. Although, there are not any original article related to nanotechnology for ergonomic product design, they are offered as the commercial products by the largest companies such as Amazon. Also, workers at the nanotechnology‐related industries have the challenges of exposure to toxic nanomaterials. So, before the application of nanomaterials, we should have proper knowledge of nanomaterials‐caused toxic hazards and how to handle them.