Occupational history and genetic N-acetyltransferase polymorphism of urothelial cancer patients in Leverkusen, Germany

Biomarkers and their use in occupational medicine

“…Older studies on the phenotype based on the slow or fast acetylation of a model compound in vivo suggested that the risk of bladder cancer was higher among slow acetylators than it is among fast acetylators (56-66); in some of the studies the difference was more marked when there was exposure to aromatic amines, such as occupational exposure or tobacco smoke. More recent studies on the genotype NAT, and also of NAT, seem to yield similar findings (67)(68)(69)(70)(71)(72). However, the relative risks have generally been rather low, less than 1.5, and, in some studies, no association between acetylator status and bladder cancer risk has been observed among patients with or without presumed exposure to aromatic amines (73,74).…”

Case-referent study on occupational risk factors for bladder cancer in southern Israel

“…The best-known occupational risk factor for bladder cancer is exposure to aromatic amines (Halperin and Schulte 1996). Restricting their use has abated this risk in certain industries, e.g., the rubber industry (Parkes et al 1982), and, possibly, in the general population (Golka et al 1996).…”

N-Acetyltransferase-2 and Medical History in Bladder Cancer Cases with a Suspected Occupational Disease (BK 1301) in Germany

“…A proportion of 82% slow NAT2 acetylators was found within this diseased group. This observation was subsequently confirmed by Golka et al (1996) and Schöps et al (1997), who found 55% slow NAT2 acetylators in an entire group of bladder cancer cases with unspecified exposure, BLADDER CANCER CASES SURVEYED FOR COMPENSATION 907 comparable to the percentage expected for the general population, 52% in bladder cancer cases definitely not occupationally exposed to aromatic amines, but 65% in a subgroup of bladder cancer cases exposed to aromatic amines.…”