Occupational inhalation of aniline fumes induced methemoglobinemea and hemolytic anemia precipitated days later

Y, Ravi Kumar; Manthappa,; Kumar, Piyush; Prasad, Manish; Radhika, A; Ac, Edara

doi:10.4103/0019-5278.146899

Cited by 3 publications

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“…Należy zwrócić uwagę, że opisywane są przypadki zatrucia związkami methemoglobinotwórczymi inhalacyjnie i przez skórę (herbicydy, samochodowe gazy spalinowe, pary aniliny) [11][12][13]. Istnieją również doniesienia o próbach eliminacji pozaustrojowej aniliny w procedurze hemodializy [14,15].…”

Section: Rycunclassified

Accidental severe poisoning with methemoglobinogenic substance: A case report

Rośniak-Bąk

Bąk

Winnicka

et al. 2017

Med Pr

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StreszczenieDo regionalnego ośrodka zatruć (ROZ) przyjęto 45-letniego pacjenta z powodu omyłkowego zatrucia pochodną dimetyloaniliny w miejscu pracy. Substancja toksyczna trafiła do organizmu drogą doustną. Podczas hospitalizacji podstawowym sposobem leczenia było podawanie błękitu metylenowego jako klasycznej odtrutki stosowanej w takim przypadku. W trakcie intensywnej opieki i leczenia u pacjenta zaobserwowano masywną hemolizę wewnątrznaczyniową, wymagającą leczenia preparatami krwiopochodnymi, oraz cechy uszkodzenia wątroby w postaci cholestatycznego uszkodzenia wątroby i żółtaczki. W Klinice Toksykologii pacjent przebywał 3 tygodnie. Opisany przypadek wskazuje na możliwość wystąpienia ciężkich powikłań narządowych w przebiegu zatrucia nawet niewielką ilością substancji chemicznej. Med. Pr. 2017;68(6):795-801 Słowa kluczowe: zatrucia, uszkodzenie wątroby, błękit metylenowy, dimetyloanilina, hemoliza, żółtaczka AbstractA 45-year-old male patient was admitted to the Regional Poison Center because of poisoning with dimethyloaniline contained in a toxic resin-curing dimethyl aniline-based formulation ingested inadvertently. Intoxication happened at workplace. The patient was then transferred to the Toxicology Clinic, where he stayed for 3 weeks. During the hospitalization, the primary method of treatment involved administration of methylene blue, which is the antidote of choice in such cases. During the intensive care and treatment of the patient massive intravascular hemolysis was seen. In that case treatment with blood products was required. He also showed signs of liver dysfunction due to cholestatic liver damage and jaundice. The reported case shows that severe organ damage may result from poisoning with even a small amount of the toxicant. Med Pr 2017;68 (6) https://doi.org/10.13075/mp.5893.00572 WSTĘPSubstancje methemoglobinotwórcze stanowią heterogenną grupę związków chemicznych. Znane są ich róż-ne klasyfikacje [1,2], jednak z punktu widzenia lekarza klinicysty najbardziej przydatnym podziałem jest rozróżnienie na substancje w bezpośrednim lub pośred-nim mechanizmie biologicznego działania. W przypadku zatrucia związkami methemoglobinotwórczymi w bezpośrednim mechanizmie działania bardzo szybko ustępują objawy sinicy i niedotlenienia, natomiast w przypadku związków wywołujących methemoglobinemię w mechanizmie pośrednim obserwowane zmiany utrzymują się przez dłuższy czas.Pochodne aniliny blokują możliwość dokomórko-wego transportu tlenu w efekcie utlenienia jonów Fe 2+

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Section: Rycunclassified

Accidental severe poisoning with methemoglobinogenic substance: A case report

Rośniak-Bąk

Bąk

Winnicka

et al. 2017

Med Pr

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Production of indigo by recombinant bacteria

Linke

Rayat

Ward

2023

Bioresour. Bioprocess.

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Indigo is an economically important dye, especially for the textile industry and the dyeing of denim fabrics for jeans and garments. Around 80,000 tonnes of indigo are chemically produced each year with the use of non-renewable petrochemicals and the use and generation of toxic compounds. As many microorganisms and their enzymes are able to synthesise indigo after the expression of specific oxygenases and hydroxylases, microbial fermentation could offer a more sustainable and environmentally friendly manufacturing platform. Although multiple small-scale studies have been performed, several existing research gaps still hinder the effective translation of these biochemical approaches. No article has evaluated the feasibility and relevance of the current understanding and development of indigo biocatalysis for real-life industrial applications. There is no record of either established or practically tested large-scale bioprocess for the biosynthesis of indigo. To address this, upstream and downstream processing considerations were carried out for indigo biosynthesis. 5 classes of potential biocatalysts were identified, and 2 possible bioprocess flowsheets were designed that facilitate generating either a pre-reduced dye solution or a dry powder product. Furthermore, considering the publicly available data on the development of relevant technology and common bioprocess facilities, possible platform and process values were estimated, including titre, DSP yield, potential plant capacities, fermenter size and batch schedule. This allowed us to project the realistic annual output of a potential indigo biosynthesis platform as 540 tonnes. This was interpreted as an industrially relevant quantity, sufficient to provide an annual dye supply to a single industrial-size denim dyeing plant. The conducted sensitivity analysis showed that this anticipated output is most sensitive to changes in the reaction titer, which can bring a 27.8% increase or a 94.4% drop. Thus, although such a biological platform would require careful consideration, fine-tuning and optimization before real-life implementation, the recombinant indigo biosynthesis was found as already attractive for business exploitation for both, luxury segment customers and mass-producers of denim garments. Graphical Abstract

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Exchange transfusion as a therapeutic modality for aniline dye-induced methaemoglobinaemia

GUPTA,

DHAGIA,

KELAIYA

et al. 2024

NMJI

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Methaemoglobinaemia and a Heinz-body haemolytic anaemia are uncommon but potentially treatable complications of aniline poisoning. Management of aniline poisoning is mainly removing the source of aniline exposure and management of methaemoglobinaemia. Management of methaemoglobinaemia is guided by blood methaemoglobin levels and patient symptoms. Blood methaemoglobin level <30% requires only supplemental oxygen while for methaemoglobin level >30%, intravenous methylene blue is the mainstay of treatment. All patients treated with methylene blue should be observed for delayed haemolysis, acute renal failure and cardiac complications. In patients with contraindication to methylene blue, exchange transfusion can be used while haemodialysis is reserved for complicated cases. We successfully managed 6 patients of methaemoglobinaemia due to aniline poisoning by methylene blue. Two of these patients who developed Heinz-body haemolytic anaemia with acute renal failure as a complication also required exchange transfusion.

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Occupational inhalation of aniline fumes induced methemoglobinemea and hemolytic anemia precipitated days later

Cited by 3 publications

References 0 publications

Accidental severe poisoning with methemoglobinogenic substance: A case report

Accidental severe poisoning with methemoglobinogenic substance: A case report

Production of indigo by recombinant bacteria

Exchange transfusion as a therapeutic modality for aniline dye-induced methaemoglobinaemia

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