Occupational Lung Disease

Sirajuddin, Arlene; Kanne, Jeffrey P.

doi:10.1097/rti.0b013e3181c1a9b3

Cited by 72 publications

(31 citation statements)

References 45 publications

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“…Silicosis is an occupational disease that is chronic and incurable; it starts in the peripheral airways and can progress even after the cessation of exposure (2). Although the incidence of silicosis has decreased since the Second World War, the disease continues to be a major cause of occupational lung disease in exposed workers (3). …”

Section: Introductionmentioning

confidence: 99%

Oscillation mechanics of the respiratory system in never-smoking patients with silicosis: pathophysiological study and evaluation of diagnostic accuracy

Sá¹,

Lopes²,

Jansen³

et al. 2013

Clinics

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OBJECTIVES:Silicosis is a chronic and incurable occupational disease that can progress even after the cessation of exposure. Recent studies suggest that the forced oscillation technique may help to clarify the changes in lung mechanics resulting from silicosis as well as the detection of these changes. We investigated the effects of airway obstruction in silicosis on respiratory impedance and evaluated the diagnostic efficacy of the forced oscillation technique in these patients.METHODS:Spirometry was used to classify the airway obstruction, which resulted in four subject categories: controls (n = 21), patients with a normal exam (n = 12), patients with mild obstruction (n = 22), and patients with moderate-to-severe obstruction (n = 12). Resistive data were interpreted using the zero-intercept resistance (R0), the resistance at 4 Hz (Rrs4), and the mean resistance. We also analyzed the mean reactance (Xm) and the dynamic compliance. The total mechanical load was evaluated using the absolute value of the respiratory impedance (Z4Hz). The diagnostic potential was evaluated by investigating the area under the receiver operating characteristic curve. ClinicalTrials.gov: NCT01725971.RESULTS:We observed significant (p<0.0002) increases in R0, Rrs4, Rm, and Z4Hz and significant reductions in Crs,dyn (p<0.0002) and Xm (p<0.0001). R0, Rrs4, Rm, and Z4Hz performed adequately in the diagnosis of mild obstruction (area under the curve>0.80) and highly accurately in the detection of moderate-to-severe obstruction (area under the curve>0.90).CONCLUSIONS:The forced oscillation technique may contribute to the study of the pathophysiology of silicosis and may improve the treatment offered to these patients, thus representing an alternative and/or complementary tool for evaluating respiratory mechanics.

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Section: Introductionmentioning

confidence: 99%

Oscillation mechanics of the respiratory system in never-smoking patients with silicosis: pathophysiological study and evaluation of diagnostic accuracy

Sá¹,

Lopes²,

Jansen³

et al. 2013

Clinics

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“…Nevertheless, it is known that computerized tomography (CT) is more sensitive in detecting pleura-parenchymal abnormalities in pneumoconiosis. Moreover, in order to detect pneumoconiosis lesions, high-resolution CT (HRCT), which is a more sensitive diagnostic tool is used [12][13][14]. Our hospital is one of the 3 reference centers for the final legal diagnosis of occupational diseases in Turkey.…”

Section: Introductionmentioning

confidence: 99%

Pneumoconiosis and respiratory problems in dental laboratory technicians: Analysis of 893 dental technicians

Ergün¹,

Ergün²,

Özdemir³

et al. 2014

IJOMEH

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Objectives: To explore the rate of pneumoconiosis in dental technicians (DTP) and to evaluate the risk factors. Material and Methods: Data of 893 dental technicians, who were admitted to our hospital in the period January 2007-May 2012, from 170 dental laboratories were retrospectively examined. Demographic data, respiratory symptoms, smoking status, work duration, working fields, exposure to sandblasting, physical examination findings, chest radiographs, pulmonary function tests and high-resolution computed tomography results were evaluated. Results: Dental technicians' pneumoconiosis rate was 10.1% among 893 cases. The disease was more common among males and in those exposed to sandblasting who had 77-fold higher risk of DTP. The highest profusion subcategory was 3/+ (according to the International Labour Organization (ILO) 2011 standards) and the large opacity rate was 13.3%. Conclusions: To the best of our knowledge, it was the largest DTP case series (N = 893/90) in the literature in English. Health screenings should be performed regularly for the early diagnosis of pneumoconiosis, which is an important occupational disease for dental technicians.

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“…45 Flavor worker's lung is a specific pattern of inhalation injury seen in patients who have been exposed to diacetyl, a ketone formerly used as butter flavoring in microwave popcorn. 46 CT findings most often include mosaic attenuation with air trapping. Bronchiectasis and bronchial wall thickening are more variable in appearance.…”

Section: Swyer-james or Macleod Syndromementioning

confidence: 98%