Occupational risk assessment of exposure to metals in chrome plating workers

Muller, Cristina Deuner; Garcia, Solange Cristina; Brucker, Natália; Göethel, Gabriela; Saüer, Elisa; Lacerda, Larissa Machado; Oliveira, Evandro; Trombini, Thereza Luciano; Machado, Aline Belem; Pressotto, Anelise; Rech, Virgínia Cielo; Klauck, Cláudia Regina; Silva, Luciano Basso da; Gioda, Adriana; Feksa, Luciane Rosa

doi:10.1080/01480545.2020.1731527

Cited by 23 publications

(12 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Prior research generally confirms that Cr hexavalent form (VI) can play a crucial role in the development and progression of lung cancer in occupationally exposed workers through either inhalation or dermal absorption [ 81 , 82 , 83 ]. Concerning prostate cancer, a recent meta-analysis indicated that exposure to chromium might moderately increase the risk among exposed workers [ 84 ].…”

Section: Discussionmentioning

confidence: 99%

Environmental Exposure to Metals, Parameters of Oxidative Stress in Blood and Prostate Cancer: Results from Two Cohorts

et al. 2022

View full text Add to dashboard Cite

We studied the potential role of exposure to various metal(oid)s (As, Cd, Cr, Hg, Ni, and Pb) in prostate cancer. Two cohorts were established: the Croatian cohort, consisting of 62 cases and 30 controls, and the Serbian cohort, consisting of 41 cases and 61 controls. Blood/serum samples were collected. Levels of investigated metal(oid)s, various parameters of oxidative stress, and prostate-specific antigen (PSA) were determined in collected samples. A comparison of the measured parameters between 103 prostate cancer patients and 91 control men from both Croatian and Serbian cohorts showed significantly higher blood Hg, SOD, and GPx levels and significantly lower serum SH levels in prostate cancer patients than in controls. Correlation analyses revealed the significant relationship between certain parameters of oxidative stress and the concentrations of the measured metal(loid)s, pointing to the possible role of metal(oid)-induced oxidative stress imbalance. Furthermore, a significant inverse relationship was found between the blood Pb and the serum PSA in prostate cancer patients, but when the model was adjusted for the impacts of remaining parameters, no significant association between the serum PSA and the measured parameters was found. The results of the overall study indicate a substantial contribution of the measured metal(loid)s to the imbalance of the oxidant/antioxidant system. Although somewhat conflicting, the results of the present study point to the possible role of investigated metal(oid)s in prostate cancer, especially for Hg, since the obtained relationship was observed for both cohorts, followed by the disturbances in oxidative stress status, which were found to be correlated with Hg levels. Nevertheless, further studies in larger cohorts are warranted to explain and confirm the obtained results.

show abstract

Section: Discussionmentioning

confidence: 99%

Environmental Exposure to Metals, Parameters of Oxidative Stress in Blood and Prostate Cancer: Results from Two Cohorts

et al. 2022

View full text Add to dashboard Cite

show abstract

“…In our study Cr (VI) exposure elevated the level of MDA and creatinine in serum. MDA is the biomarker for lipid peroxidation and protein damage results in an elevated level of MDA in serum ( Muller et al, 2022 ). MDA, the final product of lipid peroxidation, used as indicator for liver injury ( Selamoğlu et al, 2014 ).…”

Section: Discussionmentioning

confidence: 99%

Ameliorative effect of Nigella sativa conjugated silver nanoparticles against chromium-induced hepatotoxicity and renal toxicity in mice

Nauroze

Ali

Kanwal

et al. 2023

Saudi Journal of Biological Sciences

View full text Add to dashboard Cite

“…A significantly higher frequency of MN PBL [1,44,45] and MN in exfoliated buccal cells of chrome plating workers [46], has been reported. Similarly, there are studies suggesting an association between welders' Cr(VI) exposure and induction of DNA damage and its repair inhibition [47][48][49]. A study that was focused on chromate production workers also showed significantly higher MN PBL frequency, and urinary 8-OHdG levels that were associated with elevated air and blood Cr levels [50].…”

Section: Introductionmentioning

confidence: 97%

HBM4EU Chromates Study—Genotoxicity and Oxidative Stress Biomarkers in Workers Exposed to Hexavalent Chromium

Tavares

Aimonen

Ndaw

et al. 2022

Toxics

View full text Add to dashboard Cite

A study was conducted within the European Human Biomonitoring Initiative (HBM4EU) to characterize occupational exposure to Cr(VI). Herein we present the results of biomarkers of genotoxicity and oxidative stress, including micronucleus analysis in lymphocytes and reticulocytes, the comet assay in whole blood, and malondialdehyde and 8-oxo-2′-deoxyguanosine in urine. Workers from several Cr(VI)-related industrial activities and controls from industrial (within company) and non-industrial (outwith company) environments were included. The significantly increased genotoxicity (p = 0.03 for MN in lymphocytes and reticulocytes; p < 0.001 for comet assay data) and oxidative stress levels (p = 0.007 and p < 0.001 for MDA and 8-OHdG levels in pre-shift urine samples, respectively) that were detected in the exposed workers over the outwith company controls suggest that Cr(VI) exposure might still represent a health risk, particularly, for chrome painters and electrolytic bath platers, despite the low Cr exposure. The within-company controls displayed DNA and chromosomal damage levels that were comparable to those of the exposed group, highlighting the relevance of considering all industry workers as potentially exposed. The use of effect biomarkers proved their capacity to detect the early biological effects from low Cr(VI) exposure, and to contribute to identifying subgroups that are at higher risk. Overall, this study reinforces the need for further re-evaluation of the occupational exposure limit and better application of protection measures. However, it also raised some additional questions and unexplained inconsistencies that need follow-up studies to be clarified.

show abstract

Occupational risk assessment of exposure to metals in chrome plating workers

Cited by 23 publications

References 44 publications

Environmental Exposure to Metals, Parameters of Oxidative Stress in Blood and Prostate Cancer: Results from Two Cohorts

Environmental Exposure to Metals, Parameters of Oxidative Stress in Blood and Prostate Cancer: Results from Two Cohorts

Ameliorative effect of Nigella sativa conjugated silver nanoparticles against chromium-induced hepatotoxicity and renal toxicity in mice

HBM4EU Chromates Study—Genotoxicity and Oxidative Stress Biomarkers in Workers Exposed to Hexavalent Chromium

Contact Info

Product

Resources

About