Occupational risk factors for renal cell carcinoma: agent-specific results from a case-control study in Germany

Pesch, Beate; Haerting, Johannes; Ranft, Ulrich; Klimpel, Andreas; Oelschlägel, Burkhard; Schill, Walter

doi:10.1093/ije/29.6.1014

Cited by 231 publications

(126 citation statements)

References 46 publications

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“…Although Cd is known as a human lung carcinogen [1], there is some evidence that it may be related to other cancers such as human prostate cancer [3][4][5], renal cell carcinoma [6,7], and breast cancer [8,9]. The human mammary gland is a controversial target site for Cd.…”

Section: Introductionmentioning

confidence: 99%

Cadmium concentration in biological media of breast cancer patients

Strumylaitė

Boguševičius

Abdrachmanovas

et al. 2010

Breast Cancer Res Treat

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The study aimed to determine and compare cadmium (Cd) concentration in different biological media of breast cancer and benign breast tumor patients. Methods Concentration of Cd was determined in breast tissue, urine and blood of 57 breast cancer and 51 benign tumor patients. Two samples of breast tissue from each patient, i.e. tumor and healthy tissue were taken for the analysis. Cd in biological media was determined by atomic absorption spectrometry (Perkin-Elmer, Zeeman 3030). Results The mean Cd concentration in breast cancer patients was 0.053 µg/g (95% CI=0.042-0.065) for tumor sample and 0.02 µg/g (95% CI=0.014-0.026) for healthy breast tissue sample (p<0.001). In benign tumor patients the figures were following: 0.037 µg/g (95% CI=0.023-0.051) and 0.032 µg/g (95% CI=0.018-0.047) (p>0.05). Cd content in malignant tumor significantly differed from that in benign tumor (p<0.01). Cancer patients with positive estrogenreceptors had significantly greater concentration of breast tissue Cd compared to patients with negative estrogenreceptors (p=0.035). Adjusted for creatinine Cd in urine was significantly higher in cancer patients than in controls (p<0.001). In cancer patients a positive Spearman's correlation was found between Cd in tumor and healthy breast tissue, blood (r=0.44 and r=0.39, respectively, p<0.01). Correlation between Cd in urine of cancer patients and number of cigarettes smoked during lifetime was suggestive (r=0.59, p=0.075). Conclusion The data obtained show higher concentration of cadmium in breast tumor and urine of cancer patients and support a possible relationship between cadmium and breast cancer.

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Section: Introductionmentioning

confidence: 99%

Cadmium concentration in biological media of breast cancer patients

Strumylaitė

Boguševičius

Abdrachmanovas

et al. 2010

Breast Cancer Res Treat

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“…Although a sustained and sizeable decrease in human body Pb burden has been observed at the same time (Gottlieb, 1998), scientific interest and concerns among public health researchers and epidemiologists over the long-term negative potential of Pb contamination have not abated. In particular, attention has focused on reproductive, genotoxic, carcinogenic, and neurological effects (Fu and Boffetta, 1995;Apostoli et al, 2000;Hertz-Picciotto, 2000;Lorente et al, 2000;Ojajarvi et al, 2000;Pesch et al, 2000;Restrepo et al, 2000;Schwartz et al, 2000;Silbergeld et al, 2000). For these reasons, populations exposed to environmental Pb deserve to be monitored in order to detect early reversible abnormalities and lifethreatening disorders and, as a corollary result, to improve the scientific knowledge on the biological impairments attributable to Pb burdens.…”

Section: Introductionmentioning

confidence: 99%

Adverse haematological outcome and environmental lead poisoning

Fontana¹,

Baldi

Franchini

et al. 2004

J Expo Sci Environ Epidemiol

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The South-eastern Area (SA) of the Municipality of La Spezia (Liguria Region, Italy) is characterised by a heavy environmental lead (Pb) contamination, chiefly due to the emissions of a Pb-processing plant in operation since 1930. In order to assess the risk of Pb poisoning of residents of SA, and to estimate the degree of association between the blood Pb level (BLL) and haematocrit % (HCT), intended as a biomarker of early haematological dysfunction, we reanalysed data of 785 individuals collected in 1992 as a part of a larger national biological monitoring project. Multiple normal regression modelling was applied to estimate the role of residence on log-transformed BLL, and Median Ratio (MR) was used as an index of effect. The same statistical modelling was also applied to reveal the relationship between HCT and BLL. Allowing for several confounders (including occupational exposure to Pb), residents of SA showed a 14% increase (MR ¼ 1.14, 95% IC ¼ 1.06-1.23%) in the median BLL value compared to people living outside SA. The excess reached 27% (MR ¼ 1.27, 95% IC ¼ 1.14-1.41%) after 30 years of residence. Parallel results were also obtained in a subgroup composed only of pupils (o18 years, non-smokers, non-drinkers). Finally, regression analysis highlighted a statistically significant parabolic trend in HCT in relation to BLL. The non-linear dose-response relationship, which attests to an adverse effect on the erythrocytic function of BLLs at least over 17.00 mg/dl, is in agreement with the findings of other authors and consistent with the results of an excess occurrence of self-reported anaemia obtained from a previous comparative survey carried out on the same population.

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“…Hypertension as well as occupational exposure to substances such as asbestos, cadmium, and solvents have been linked to an increased risk of RCC [7][8][9][10]. Among dietary factors, an inverse relationship between risk and consumption of vegetables and fruits has been found [11].…”

Section: Introductionmentioning

confidence: 99%

Reliability of serum iron, ferritin, nitrite, and association with risk of renal cancer in women

Ali

Akhmedkhanov

Zeleniuch-Jaquotte

et al. 2003

Cancer Detection and Prevention

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Reliability of serum levels of iron, ferritin and nitrite (NO 2 − ) over a 2-year period were evaluated in 40 healthy women (20 pre-menopausal and 20 post-menopausal), ages 39-65 years, from the New York University Women's Health Study (NYUWHS). Three blood samples per woman collected at yearly intervals were analyzed. Reliability coefficients (RCs) of serum iron, ferritin, and nitrite were 0.03 (95% confidence interval ( In a case-control study nested within NYUWHS cohort, serum levels of nitrite, ferritin, and iron were measured in women apparently healthy at the time of blood donation but diagnosed with renal cancer 1.8-12.2 years later (n = 24) and in individually matched controls (two per case). The results suggest that high serum levels of ferritin and nitrite may be associated with a decreased risk of renal cancer (odds ratio (OR), 0.55, 95% CI, 0.15-2.01 for ferritin, and OR, 0.52, 95% CI, 0.17-1.60 for nitrite in women with above median level as compared to women with below median level). The possible role of ferritin and nitrite in renal cancer is discussed.

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Occupational risk factors for renal cell carcinoma: agent-specific results from a case-control study in Germany

Abstract: Our results indicate that substantial exposure to metals and solvents may be nephrocarcinogenic. There is evidence for a gender-specific susceptibility of the kidneys.

Cited by 231 publications

References 46 publications

Cadmium concentration in biological media of breast cancer patients

Cadmium concentration in biological media of breast cancer patients

Adverse haematological outcome and environmental lead poisoning

Reliability of serum iron, ferritin, nitrite, and association with risk of renal cancer in women

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