Occupational Safety and Health

Bouwman-Boer, Yvonne; Ng, Shi Wai; Crauste–Manciet, Sylvie

doi:10.1007/978-3-319-15814-3_26

Cited by 4 publications

(3 citation statements)

References 44 publications

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“…By spraying the disinfectant can penetrate into difficult-to-reach surfaces. However, the impact of alcohol aerosols on the operators restricts the use of spraying 5. Therefore, wiping only is the preferred method of disinfection in the Netherlands, but its efficacy has not been examined.…”

Section: Introductionmentioning

confidence: 99%

Improving the aseptic transfer procedures in hospital pharmacies. Part B: evaluation of disinfection methods for materials with a non-sterile surface

et al. 2019

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ObjectivesTo improve the disinfection methods for materials with a non-sterile surface to be used in aseptic handling.MethodsThe surface bioburden on ampoules (A) and injection vials (IV) is determined by contact plates and total immersion. The occurrence of spore-forming bacteria is determined by strain colouring and matrix-assisted laser desorption ionisation-time of flight mass spectrometry. The disinfection procedures of non-sterile materials in 10 hospital pharmacies are judged by observing.ResultsAfter wiping according to local disinfection methods, the mean surface bioburden determined by contact plates in 10 hospital pharmacies is 0.36 (plastic A), 0.50 (glass A) and 0.29 colony-forming unit (cfu) (IV). The observers found great differences in accuracy of wiping and degree of wetting the sterile gauzes.After improved wiping with commercially available alcohol impregnated sterile wipes and a two-towel technique (one-step TT disinfection), the mean surface bioburden determined by contact plates is 0.03 (plastic A), 0.2 (glass A) and 0.13 cfu (IV). Further improvement can be reached by submerging A and IV in ethanol 70% followed by improved wiping (two-step TT disinfection), but still micro-organisms will remain (mean surface bioburden determined by total immersion is 0 (plastic A) and 0.3 cfu (IV); glass A not determined). Two-step TT disinfection is more labour intensive. Spilling of alcohol is another disadvantage. However, we presume one-step TT disinfection is effective enough in daily practice. Routine surface bioburden determinations have to prove this.The effectiveness of the combination of spray and wipe is not examined because we observed a quick disappearance of alcohols from vertical as well as horizontal surfaces, which shortens the contact time to far below the advised 2 min.Spore-forming bacteria disappear as quickly as other micro-organisms during disinfection by alcohols.ConclusionLocal disinfection procedures can be improved. Complete removal of micro-organisms from materials with a non-sterile surface, even after two-step TT disinfection, is impossible. Routine surface bioburden determinations have to prove if one-step TT disinfection is effective enough.

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Section: Introductionmentioning

confidence: 99%

Improving the aseptic transfer procedures in hospital pharmacies. Part B: evaluation of disinfection methods for materials with a non-sterile surface

et al. 2019

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“…Next, a risk analysis was performed based on the risk matrix that had previously been established by the Netherlands Association of Applied Scientific Research and is used commonly in the Netherlands in compounding pharmacies. 6 , 13 , 14 The basis for this risk matrix is the subdivision of pharmaceutical substances into five hazard categories, with category 1 being the lowest, and category 5 the highest. All commercially available active pharmaceutical ingredients and commercially available drug products are classified into one of the five categories in a national database, with the classification being a combined result of acute and chronic toxicity of the substance, derived from H-statements according to CLP/REACH regulations, 15 available occupational exposure limits, and toxicological and pharmacotherapeutic information.…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Limited Health Risks in Performing Drug Reconstitution and Handling Tasks in Pharmacies—Results of an Occupational Risk Assessment Study

Crul¹,

Breukels²,

Ng³

et al. 2023

J Occup Environ Med

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Objective: Some drugs need processing before they can be administered or dispensed. We measured airborne exposure of pharmacy staff to small particles when performing these tasks. Methods: Reconstitution of powdered drugs in vials; crushing, splitting, and counting of tablets; and opening of capsules, using different ventilation strategies, were investigated in five pharmacies after in a worst-case approach. Airborne particulate matter was determined for a range of particles sizes. Results: Mean particle concentrations ranged from not detectable to 1.03 μg/m 3 (<1 μm) and 589.7 μg/m 3 (<10 μm). Dust exhaust made tasks safer. Most hazardous was pouring out tablets from a bulk supply, and least hazardous was reconstitution of a powder for injection. Conclusions: Occupational exposure during routine handling of drugs can occur, but the risks vary greatly with the nature and duration of the tasks.

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With a little help from my boss: The impact of workplace mental health training on leader behaviors and employee resource utilization.

Dimoff

Kelloway

2019

Journal of Occupational Health Psychology

109

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Mental health problems are among the costliest issues facing organizations in the developed world. In response to the mounting burdens surrounding poor employee mental health, many organizations have introduced mental health promotion programs and resources (e.g., employee assistance programs). Despite the rise in available options, very few employees use these resources to their full potential. Using a wait-list control design with random assignment, we evaluate the impact of a leader-focused mental health training on employees' ( = 82; 51.25% response rate) resource use and leaders' ( = 37; 56.92% response rate) communication about mental health and mental health resources. Based on other-report data from employees, leaders who received training shared more information about mental health and mental health resources, were more supportive of employees' mental health issues, and actively encouraged employees to use available resources. Employees whose leaders attended the training also reported increased willingness to seek out and use available resources. For leaders who attend training and complete three waves of data collection, results suggest that a 3-hr mental health training may lead to significant behavioral change up to 3 months posttraining. (PsycINFO Database Record

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Occupational Safety and Health

Cited by 4 publications

References 44 publications

Improving the aseptic transfer procedures in hospital pharmacies. Part B: evaluation of disinfection methods for materials with a non-sterile surface

Improving the aseptic transfer procedures in hospital pharmacies. Part B: evaluation of disinfection methods for materials with a non-sterile surface

Limited Health Risks in Performing Drug Reconstitution and Handling Tasks in Pharmacies—Results of an Occupational Risk Assessment Study

With a little help from my boss: The impact of workplace mental health training on leader behaviors and employee resource utilization.

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