Occurrence and distribution of canine cutaneous mast cell tumour characteristics among predisposed breeds

Abstract

Introduction: Breed predisposition to cutaneous mast cell tumours (MCT) in a population of dogs in Poland affected by various skin tumours was assessed, and the distribution of MCT characteristics such as histological grading, sex, age, and location, in predisposed breeds was evaluated. Material and Methods: The retrospective epidemiological study included 550 dogs affected by cutaneous MCTs with a reference group of 2,557 dogs diagnosed with other skin tumours. Results: A univariable logistic regression analysis was performed to determine the odds ratios (ORs) with 95% confidence intervals. The risk of high-grade MCTs was the highest for Shar-Peis (OR: 26.394) and American Staffordshire Terriers (OR: 2.897). Boxers (OR: 6.619), Labrador Retrievers (OR: 2.630), French Bulldogs (OR: 2.050), Golden Retrievers (OR: 1.949), and American Staffordshire Terriers (OR: 2.592) were mainly affected by low-grade MCTs. The high risk of MCT was calculated to be at the age of 4–6 years for Labrador Retrievers (OR: 2.686) and 7–10 years for Boxers (OR: 2.956) and French Bulldogs (OR: 9.429). MCTs were significantly more often located on the trunk in French Bulldogs (OR: 4.680), American Staffordshire Terriers (OR: 2.520), and Labrador Retrievers (OR: 1.948). There was no statistically significant correlation between gender and the occurrence of MCTs in the breeds. Conclusions: The breed-predicated differences in the clinical course of MCTs suggest a genetic background for the tumours.

Disorder predispositions and protections of Labrador Retrievers in the UK

“…These values are similar to the respective estimates reported previously by studies of Labrador Retrievers with similar methodologies of 7.4-14.8% for neoplasia and 4.80-8.26% for mass disorders 27,28 . These results are supported by reported predispositions in Labrador Retrievers to neoplasms including lingual squamous cell carcinoma 70 , mast cell tumours [71][72][73] , soft tissue sarcoma 72 melanomas 74 and various neoplasms of the thoracic limb 75 .…”

Diagnosis, Prognosis and Treatment of Canine Cutaneous and Subcutaneous Mast Cell Tumors

“…in Brazil have described an incidence ranging between 20.9% and 22.4%, revealing MCT as the second-most frequent malignant neoplasm in dogs, after mammary gland tumors [16][17][18]. Some breeds are predisposed to MCT development, including Boxer; Bull Terrier; French Bulldog; Golden Retriever; Labrador Retriever; Shar-pei; and Dachshund [16,[19][20][21][22][23][24][25][26][27].…”

“…Stage IV would be characterized by the presence of extensive and infiltrative formations or multiple formations with lymph node involvement, and stage V, when there is the presence of distant metastases (Table 3). [11,27], Adapted from the World Health Organization System.…”

“…Some breeds are predisposed to MCT development, including Boxer; Bull Terrier; French Bulldog; Golden Retriever; Labrador Retriever; Shar-pei; and Dachshund [ 16 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 ]. On the other hand, some breeds present a lower risk of MCT development, including the German Shepherd, Chihuahua, Poodle, Yorkshire Terrier, and Cocker Spaniel [ 24 , 25 ].…”

Immunohistochemical and molecular profiling of CD 117, Oct-4, and Sox-2 in canine cutaneous mast cell tumor of the crossbred dogs in Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand

“…Nevertheless, MCT clinical behavior and aggressiveness seem to be influenced by dog breeds [15]. A plethora of evidence has suggested that purebred dogs such as Boxers, Labrador Retrievers, Golden Retrievers, French Bulldogs, Dachshunds, and Shar-Pei are at risk of MCT [16][17][18]. However, little is known about crossbred dogs.…”