Occurrence and partitioning of antibiotic compounds found in the water column and bottom sediments from a stream receiving two wastewater treatment plant effluents in Northern New Jersey, 2008

Gibs, Jacob; Heckathorn, Heather A.; Meyer, Michael T.; Klapinski, Frank R.; Alebus, Marzooq; Lippincott, R. Lee

doi:10.1016/j.scitotenv.2013.03.076

Cited by 98 publications

(44 citation statements)

References 25 publications

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“…Frequently sulfonamides, especially SMX, have the highest detection frequency and concentration over other antimicrobials tested in wastewaters (Chen and Zhou, 2014) however sediments are more informative of long-term accumulation and storage of drugs, being also a source of exposure to benthic and other aquatic organisms. Gibs et al (2013) describe a likely cause for the declining trend of erythromycin and other antibiotics occurrence from the point source as a dilution from groundwater discharge and sorption to bottom sediments. The observed drug concentrations can be attributed to sorption from the concentration in the water column and subsequent sediment transport (Gibs et al, 2013).…”

Section: 3pharmaceuticals In Water and Sediment -Sources Of Exposurementioning

confidence: 99%

“…Gibs et al (2013) describe a likely cause for the declining trend of erythromycin and other antibiotics occurrence from the point source as a dilution from groundwater discharge and sorption to bottom sediments. The observed drug concentrations can be attributed to sorption from the concentration in the water column and subsequent sediment transport (Gibs et al, 2013). In the sedimentary phase, the total concentration of antibiotics in this work decreased from 144.55 to 18.58 ng/g with the distance from the WWTP, which is comparable with the work of Chen and Zhou (2014) (101.0 to 12.4 ng/g).…”

Section: 3pharmaceuticals In Water and Sediment -Sources Of Exposurementioning

confidence: 99%

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Impact of treated wastewater on organismic biosensors at various levels of biological organization

Popović

Strunjak‐Perović

Klobučar

et al. 2015

Science of The Total Environment

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Relating the treated wastewater quality and its impact on organismic biosensors (Prussian carp, Carassius gibelio and earthworm, Eisenia fetida) was the main objective of the study. The impact on health status of fish living downstream, microbiological contamination and antimicrobial resistance, fish tissue structure, blood biochemistry, oxidative stress, genotoxic effects, as well as multixenobiotic resistance mechanism (MXR) was assessed. Treated wastewater discharged from the WWTP modified the environmental parameters and xenobiotic concentrations of the receiving surface waters. Potential bacterial pathogens from fish and respective waters were found in relatively low numbers, although they comprised aeromonads with a zoonotic potential. High resistance profiles were determined towards the tested antimicrobial compounds, mostly sulfamethoxazole and erytrhomycin. Histopathology primarily revealed gill lamellar fusion and reduction of interlamellar spaces of effluent fish. A significant increase in plasma values of urea, total proteins, albumins and triglycerides and a significant decrease in the activity of plasma superoxide dismutase were noted in carp from the effluent-receiving canal. Micronucleus test did not reveal significant differences between the examined groups, but a higher frequency of erythrocyte nuclear abnormalities was found in fish sampled from the effluent-receiving canal. Earthworms indicated to the presence of MXR inhibitors in water and sludge samples, thus proving as a sensitive sentinel organism for environmental pollutants. The integrative approach of this study could serve as a guiding principle in conducting evaluations of the aquatic habitat health in complex bio-monitoring studies.Response to Reviewers: The response is attached as a separate file. We request that this manuscript be considered for publication in Science of the Total Environment as an original, full paper. This manuscript has not been published and is not under consideration for publication in any other journal. All authors concur with the submission.The manuscript is a result of a comprehensive study which integrated various disciplines and research fields. The authors decided to present it as a whole rather than splitting it in two or more papers, for a better understanding of the discussed subject. We believe we have presented a potential guiding principle for conducting evaluations of the aquatic habitat health in complex bio-monitoring studies.I will be serving as the corresponding author for the manuscript. We hope that it is found to be interesting and appropriate for publication in Science of the Total Environment. Should you have any questions, please do not hesitate to contact me.Yours truly, Natalija Topic Popovic, DVM, PhD Response: Thank you for this clarification. We have taken a whole different approach and completely rewritten all sections relating to the PCA as they were indeed confusing, and created a new biplot for plasma parameters. We hope that the new text, as inserted in the respect...

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Section: 3pharmaceuticals In Water and Sediment -Sources Of Exposurementioning

confidence: 99%

Section: 3pharmaceuticals In Water and Sediment -Sources Of Exposurementioning

confidence: 99%

Impact of treated wastewater on organismic biosensors at various levels of biological organization

Popović

Strunjak‐Perović

Klobučar

et al. 2015

Science of The Total Environment

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“…Tendo em vista que os produtos farmacêuticos são originalmente fabricados para causar efeitos biológicos específicos (SIM; LEE; OH, 2010) e que ainda não há regulamentação abrangente para concentrações no meio ambiente (GARZA-CAM-POS et al, 2016), esses compostos têm despertado crescente preocupação entre pesquisadores devido à sua ocorrência, persistência e potencial ecotoxicológico ao meio ambiente e à saúde dos seres humanos (STUMPF et al, 1999;MONTAG-NER;JARDIM, 2007;ZHANG et al, 2007;AL-ODA-INI et al, 2010;AMÉRICO et al, 2012;LÓPEZ-SER-NA;PETROVI;BARCELÓ, 2012;RODIL et al, 2012;MARTÍN et al, 2012;GIBS et al, 2013;CAMPA-NHA et al, 2015;JANK et al, 2014;THOMAS et al, 2014;GAVRILESCU et al, 2015;KRAMER et al, 2015;EBELE;ABDALLAH;HARRAD, 2016;LO-NAPPAN et al, 2016;BALAKRISHNA et al, 2017;DINH et al, 2017;DODGEN et al, 2017;EKPEGHE-RE et al, 2017;GROS et al, 2017;MARSIK et al, 2017;MIRZAEI et al, 2017;SUBEDI et al, 2017;YAO et al, 2017).…”

Section: Introductionunclassified

Revisão sobre fármacos no ambiente

Bisognin¹,

Wolff²,

Carissimi³

2018

RDAE

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ResumoA presença de micropoluentes em águas residuárias e naturais, como fármacos, tem despertado preocupação na comunidade científica devido a sua ocorrência, persistência e potencial deletério à saúde humana e aos ecossistemas. Tal preocupação tem sido impulsionada pela capacidade de detecção de substâncias químicas por equipamentos avançados e métodos mais sensíveis. Dessa forma, estudos de investigação e técnicas de tratamento para degradação de compostos farmacêuticos em matrizes aquosas estão sendo intensificados. Diante da relevância do assunto, este artigo consiste em uma revisão da literatura sobre fármacos largamente encontrados no ambiente, principalmente em águas residuárias e superficiais. Palavras-chave: Micropoluentes. Determinação analítica. Tratamento. AbstractThe presence of micropollutants in wastewater and natural waters, such as pharmaceuticals, have aroused concern in the scientific community due to their occurrence, persistence and deleterious potential to human health and ecosystems. Such concern has been boosted by the ability to detect chemicals by advanced equipment and more sensitive methods. Thus, research studies and treatment techniques for the degradation of pharmaceutical compounds in aqueous matrices are being intensified. Given the relevance of the subject, this article consists of a review of the literature on pharmaceuticals widely found in the environment, mainly in wastewater and surface water.

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“…Após a administração, estes fármacos são liberados no ambiente através de processos de excreção dos animais, sendo que estas substâncias podem migrar para distintos recursos hídricos. Vários estudos têm citado a ocorrência de RMVs em águas superficiais, lençóis freáticos e efluentes de estações de tratamento (DÍAZ-CRUZ et al, 2008;DONG et al, 2013;FERRER et al, 2010;GIBS et al, 2013). Muitos trabalhos têm relatado ações sobre espécies não-alvo que incluem disrupção endócrina, inibição reprodutiva e até mesmo respostas em nível de ecossistema (BOXALL et al, 2003;BOXALL, 2004;BRASCHI et al, 2013;CAPLETON et al, 2006;SANTOS et al, 2013;WALL;STRONG, 1987).…”

Section: Introductionunclassified

Monitoramento De Resíduos De Medicamentos Veterinários Em Alimentos E No Ambiente: Modelo Para Avaliação

Hoff¹

2018

SCI. ANIM. HEALTH

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O trabalho apresenta uma proposta para elencar prioridades na pesquisa de resíduos de fármacos de uso veterinário utilizados em larga escala na produção animal, tanto em alimentos destinados ao consumo humano como no ambiente. Para exemplificar o modelo proposto, adotou-se neste trabalho o caso específico das sulfonamidas, analisando-se as apresentações farmacêuticas disponíveis no mercado veterinário nacional em dois momentos distintos (2007 e 2017). Segundo o modelo proposto, pode-se dizer que o mesmo é adequado para subsidiar políticas regulatórias e delineamentos de experimentos de métodos de monitoramento de resíduos de medicamentos.

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Occurrence and partitioning of antibiotic compounds found in the water column and bottom sediments from a stream receiving two wastewater treatment plant effluents in Northern New Jersey, 2008

Cited by 98 publications

References 25 publications

Impact of treated wastewater on organismic biosensors at various levels of biological organization

Impact of treated wastewater on organismic biosensors at various levels of biological organization

Revisão sobre fármacos no ambiente

Monitoramento De Resíduos De Medicamentos Veterinários Em Alimentos E No Ambiente: Modelo Para Avaliação

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