Occurrence and prognostic effect of cervical spine injuries and cervical artery injuries with concomitant severe head injury

Vehviläinen, Juho; Brinck, Tuomas; Lindfors, Matias; Numminen, Jussi; Siironen, Jari; Raj, Rahul

doi:10.1007/s00701-020-04279-9

Cited by 6 publications

(4 citation statements)

References 42 publications

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“…The prevalence of spinal injuries was 12% among patients with head injuries. The results of the prevalence of spinal injuries in the current study are in line with that of a Hong Kong study [ 11 ] and a retrospective study [ 18 ]. However, the results of the prevalence of spinal injuries were not in line with that of a retrospective study [ 3 ] and an ecological study [ 7 ].…”

Section: Discussionsupporting

confidence: 89%

Concurrent Spinal Trauma in Patients with Traumatic Head Injury: A Seven-Year Retrospective Analysis

2023

Med Sci Monit

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Background Assessing spinal injuries in patients with traumatic head injuries is crucial due to their potential to alter functionality and increase mortality rates. This single-center retrospective study was conducted to understand the prevalence and characteristics of concurrent spinal injuries in adults with traumatic head injury from April 2015 to April 2022. Material/Methods The study incorporated demographic, clinical, traumatological, and hemodynamic data from 1,501 adult patients presenting with traumatic head injuries. Spinal injuries were identified through symptoms, physical signs, and radiological findings. Results During the study period, 179 patients (12%) were reported with associated spinal injuries. These patients were predominantly male (p=0.0012), aged 65 years or above (p=0.0452), had thoracic injuries (p=0.0004), and arrived at the emergency department more than three hours post-trauma (p=0.0004). Most injuries were caused by motor vehicle accidents (p=0.0412) or falls from heights greater than 3 meters (p=0.0481). In addition, these patients had higher Abbreviated Injury Scale scores (≥2, p=0.0391), Eppendorf-Cologne Scale scores (≥2, p=0.0412), and lower systolic and diastolic blood pressure readings (p=0.0481, p=0.0412) along with lower heart rates (p=0.0482). However, no correlation was found between systolic and diastolic pressures and age among patients with spinal injuries. Conclusions This study reveals that the prevalence and severity of spinal injuries in patients with traumatic head injuries are influenced not only by demographic and clinical parameters, but also by the degree and extent of head trauma.

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Section: Discussionsupporting

confidence: 89%

Concurrent Spinal Trauma in Patients with Traumatic Head Injury: A Seven-Year Retrospective Analysis

2023

Med Sci Monit

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“…Ulinastatin is an endogenous protective substance reducing the release of elastase, trypsin, and some lipid hydrolases to inhibit the expression of inflammatory factors [ 16 , 17 ]. Meanwhile, it can also prevent the generation of oxygen free radicals, improve the microcirculation in patients, and reduce the damage of tissues and organs under inflammatory and ischemic conditions so as to increase the tolerance of the liver to hypoxia [ 18 – 20 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Ulinastatin Combined with Xingnaojing Injection on Severe Traumatic Craniocerebral Injury and Its Influence on Oxidative Stress Response and Inflammatory Response

Yin

Zhang

et al. 2022

BioMed Research International

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Objective. This study is aimed at exploring the effect of ulinastatin combined with Xingnaojing injection on severe traumatic craniocerebral injury and its influence on oxidative stress response and inflammatory response in patients. Methods. A total of 100 patients with severe traumatic craniocerebral injury admitted to our hospital from January 2018 to January 2020 were selected and equally assigned into a study group (50 cases) and a control group (50 cases) according to a random sampling method. Patients in study group received treatment of ulinastatin combined with Xingnaojing injection, while those in control group were treated with ulinastatin only. The study compared the two groups on the oxidative stress response, inflammatory response, the therapeutic effect, and the incidence rate of adverse reactions. Results. It is observed that patients in study group obtained lower levels of free cortisol (FC) and norepinephrine (NE) in the serum and higher level of total thyroxine (TT4) after treatment compared with those in control group with significant difference ( P < 0.05 ); in the meantime, they were examined to have significantly fewer oxidative stress response products, lower serum inflammatory factor level, and serum indicator levels of craniocerebral injury as opposed to those in control group, suggesting significant differences ( P < 0.05 ); study group demonstrated higher treatment response rate and lower incidence rate of adverse reactions compared with control group with a significant difference ( P < 0.05 ). Conclusion. The study found that ulinastatin combined with Xingnaojing infection has a significant effect in the treatment of severe traumatic craniocerebral injury, which can reduce the degree of craniocerebral injury and the level of inflammatory factors in the serum of patients. It is worthy of being promoted and applied clinically.

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“…The operation time, coagulation function time, hospitalization time, body temperature recovery time, PT, APTT, blood loss, total fluid input and fatality rate of the three groups of subjects were statistically significant. This shows that in the early treatment work, the improvement of the sufferer's vital signs creates a prerequisite for DCR surgery [19][20][21] . During the treatment process, it is necessary to keep the sufferer warm and detect blood volume, and take targeted measures according to the actual situation.…”

Section: Table 1: Basic Information Of Drugsmentioning

confidence: 99%

Effects of Damage Control Resuscitation Combined with Alanyl Glutamine on Complications and Survival in Sufferers with Severe Multiple Trauma

Chen¹,

He²,

Luo³

et al. 2022

IJPS

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To explore the clinical value of damage control resuscitation combined with alanyl glutamine in the treatment of severe multiple trauma sufferers is the main objective of the study. A total of 120 sufferers with injury severity score≥16 points of severe multiple trauma who were admitted to our hospital from November 2019 to February 2022 were selected and separated into blank group and intervention group (group J and group M) according to random grouping method with 40 people in each group. The general information, clinical indicators, thromboelastography indicators, complications and survival rate of the sufferers were recorded. The operation time, coagulation function time, hospitalization time, body temperature recovery time, prothrombin time, activated partial thromboplastin time, blood loss, total fluid input and mortality of the study subjects were statistically significant. The coagulation indexes of the three groups of research subjects before blood transfusion were not statistically significant and the coagulation indexes of the intervention group (J and M groups) after blood transfusion were statistically significant compared with the blank group. Damage control resuscitation combined with alanyl glutamine significantly reduces complication rates in sufferers with severe polytrauma, thereby improving the survival rate of sufferers after surgery.

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Occurrence and prognostic effect of cervical spine injuries and cervical artery injuries with concomitant severe head injury

Cited by 6 publications

References 42 publications

Concurrent Spinal Trauma in Patients with Traumatic Head Injury: A Seven-Year Retrospective Analysis

Concurrent Spinal Trauma in Patients with Traumatic Head Injury: A Seven-Year Retrospective Analysis

Effect of Ulinastatin Combined with Xingnaojing Injection on Severe Traumatic Craniocerebral Injury and Its Influence on Oxidative Stress Response and Inflammatory Response

Effects of Damage Control Resuscitation Combined with Alanyl Glutamine on Complications and Survival in Sufferers with Severe Multiple Trauma

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